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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Targeting mitochondrial α-keto" (28 stories)

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Mitochondrial dysfunction in diabetic cardiomyopathy: a review of pathogenic mechanisms and therapeutic strategies
Lead StoryFrontiersworld
Feb 19

Mitochondrial dysfunction in diabetic cardiomyopathy: a review of pathogenic mechanisms and therapeutic strategies

<a href="https://news.google.com/rss/articles/CBMiogFBVV95cUxQVXIyNWhQeEJKdmNWUXI1SU1zamxGaGFzNXQzZmZJMHg1UjJZZnhiVzJocHd0WFlfdlp1QVpGRDFPMmZNcmtlX2hlZlBhRkRIM1QxbU1tdVJGVVNHRFJnS2NNR0prVDRLTENUaGhtSUlQUV8yT3FhS05yRXBuZ0IzVzdXS2UwWkZSTEg5cm9NMGJ6T1pGRDZXSWN4eFFCTzNIWXc?oc=5" target="_blank">Mitochondrial dysfunction in diabetic cardiomyopathy: a review of pathogenic mechanisms and therapeutic strategies</a>  <font color="#6f6f6f">Frontiers</font>

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Search Results for "Targeting mitochondrial α-keto"

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27 stories displayed
Metabolic reprogramming in cardiac fibrosis: mechanisms, crosstalk, and therapeutic interventions
Frontiersgeneral

Metabolic reprogramming in cardiac fibrosis: mechanisms, crosstalk, and therapeutic interventions

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxNOHdnaEVnSDdBWWpiRWkyWk5fTGFwVm9hejRDSFRNZDlPV0gwZjNNbUl5S1hDNmJtN1BSX0pPbGxjcDRNa3JOaGFFZTZEZmw2Y1dOVHMzdlZkVG1VSGFLckNPLXFVaEdhanpTYU9mdEdVaW5YQmE2VlVQWTk3YzBTYzlCNmZqaUhWWU5CQlpORkRTUQ?oc=5" target="_blank">Metabolic reprogramming in cardiac fibrosis: mechanisms, crosstalk, and therapeutic interventions</a>  <font color="#6f6f6f">Frontiers</font>

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Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential
Naturegeneral

Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5MY1FsSFpwcEU5enMzRGFlSjQ5MXg2bjhDUWlkcHNXNGtYMm1Zakt1N0NOY1JzSkxqdFNVMkE4RldzNmVabTFqcXJMdjN4SENwck82UUJRRTdsRGZoRFFv?oc=5" target="_blank">Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential</a>  <font color="#6f6f6f">Nature</font>

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A ketogenic diet combined with exercise alters mitochondrial function in human skeletal muscle while improving metabolic health
American Physiological Society Journalscience

A ketogenic diet combined with exercise alters mitochondrial function in human skeletal muscle while improving metabolic health

<a href="https://news.google.com/rss/articles/CBMidkFVX3lxTE9mUnNNV3VFTWRvUC1hdWVWS2VRdE0tREFvc2NKZHRLUlpwSmJSa0ZjUm1Mb2RILTlhUXNSeWZkN2dUQXNfdkwxYjFqYmRLNFdoeTEyRndNWkNsZk1MREVZTF9FZW50ZGFra0x2Y0x4MHNSNDFKM2c?oc=5" target="_blank">A ketogenic diet combined with exercise alters mitochondrial function in human skeletal muscle while improving metabolic health</a>  <font color="#6f6f6f">American Physiological Society Journal</font>

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Mitochondrial diseases: from molecular mechanisms to therapeutic advances
Naturegeneral

Mitochondrial diseases: from molecular mechanisms to therapeutic advances

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9tZThxS2ZUaVAzSUNUVExmOTRDeHpuSGtiRE84bjdNdTZPcGxSbFdCaGgwaVk3bk5TYVYwNVpaeEtzXzgyTHhTamJSYldsWEIxMVUtNDRYZGhpbkI3dWIw?oc=5" target="_blank">Mitochondrial diseases: from molecular mechanisms to therapeutic advances</a>  <font color="#6f6f6f">Nature</font>

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Branched-chain amino acids and insulin resistance in type 2 diabetes: from metabolic dysregulation to therapeutic targets
Frontierstech

Branched-chain amino acids and insulin resistance in type 2 diabetes: from metabolic dysregulation to therapeutic targets

<a href="https://news.google.com/rss/articles/CBMilgFBVV95cUxNRjRvTS1IbXhheGpOb1BBc3hVZmhrMzVjVmhadWhGY2NzQk5IUV9OWmxEUWxrRjRTVVpSZUpxMk1CUjhVMWxaN0Ytd1pueUpVWU42X3d5VDRMT19KekxpOGJfMTFLb1diU0F4N05vaXQ2b0UyMGxXdm5qbUZCdzI5aEs5ZDRSVTVSeU40NGhyWTV5cVE3NkE?oc=5" target="_blank">Branched-chain amino acids and insulin resistance in type 2 diabetes: from metabolic dysregulation to therapeutic targets</a>  <font color="#6f6f6f">Frontiers</font>

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Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis
Naturegeneral

Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1RSEtEZVVOZng2UXBwaDVDRGNlSG5EUktobFdDc0RFYTI4cWthcXdRVWxmczJtdGFDXzRfOEpUYnl0Sll0OXBqdlhQNUJfTjdHelRIR01ZbHFMcW9LZlVz?oc=5" target="_blank">Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis</a>  <font color="#6f6f6f">Nature</font>

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Mitochondrial transfer-mediated metabolic reprogramming and drug resistance in bone metastasis: mechanisms and therapeutic strategies
Frontiersgeneral

Mitochondrial transfer-mediated metabolic reprogramming and drug resistance in bone metastasis: mechanisms and therapeutic strategies

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxPVVhQbGNIVUJqYWxWVHN4TnZVTHhfeHhvb3JVd19IVkM2YkljWXhFS2ExRG5lWlBTeVl0cVZBQ0V1XzBrUnpzSWtnZWl4ZWUtZF9NVXdqd1UzUGRWWVdid1lhU3RVMGF6ZTZKcTRRRnNITWg2Rzh6WWxrNlJGMGdHUHBRMjJBWE1mOEotVVVoZ1Y3UQ?oc=5" target="_blank">Mitochondrial transfer-mediated metabolic reprogramming and drug resistance in bone metastasis: mechanisms and therapeutic strategies</a>  <font color="#6f6f6f">Frontiers</font>

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Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis
Naturetech

Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBjTjJWaUNUeFN6MWlUSWtjcVZ2YkVVbjBoNzJQRHA1WjEtWUtGdjJNZHhwRVFZeWlLcF9CVS1pbl9UWjN0M3JpRVhvbjJEUVhwbkhjMG83S2xrMURIZ2hV?oc=5" target="_blank">Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis</a>  <font color="#6f6f6f">Nature</font>

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Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
Naturegeneral

Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5RbGpQU3BEeGgyN1BmeWtjSVpaUHJjdWViNUREOXRXcU1waWNfdE55U1JLZkRPd2oxOTRUVVdodXcyNlVPTkowakUwck9DQXVqa2Q3eHpNemFxUm9HMDRz?oc=5" target="_blank">Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases</a>  <font color="#6f6f6f">Nature</font>

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Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease
Frontiersworld

Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease

<a href="https://news.google.com/rss/articles/CBMioAFBVV95cUxQN21RTmJIUEtUbmV4eENyM3c1Z1MtSjZpNWdOdlMwZ25DSmNrOXRUTy05Y0xnbFBrbHJ5X1FXWXJDQ3l1ZDJjeFJ3RUdjcDJ0UWItbVBGSUM5bFFIUHotSjVCaFp1bFZlR290QkdNUFFZTThiU1pDc3ZJNnlISVdPMXhXUVVoUlJ6VVhLTHotNjJxano5WEZIMFFMb1l4ZE5r?oc=5" target="_blank">Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease</a>  <font color="#6f6f6f">Frontiers</font>

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Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats
Naturegeneral

Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9VQUtpTWUzNVZwWWhtZTRRVU9ScFVGSEV1NlhkalhhTldNVVBQU2I1Q3RmSjBzMjNfbTdwMzRzWEVMSW1JTVZwVFpLampmS0wxcHhreWFaX1dja3pNWW93?oc=5" target="_blank">Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats</a>  <font color="#6f6f6f">Nature</font>

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The Role of Intermittent Fasting in Parkinson's Disease
Frontiersgeneral

The Role of Intermittent Fasting in Parkinson's Disease

<a href="https://news.google.com/rss/articles/CBMijwFBVV95cUxOR05xVzdSQ2NCQVVyTW92RXZRTHNxem5jOW4tN3FSZ3o5Mm9FcXJhQVhyd29Ham0zVTVWUDFYb2FXd1JxTWpHeHMzNjI5SWxmT2FsOV9sU05ueURacXQxTXdvSXNjMWNuODUyb1NHeXNUSThjbW5vWXdHTzNUbVBVNW93TFpVbXE3VGpmc3gtVQ?oc=5" target="_blank">The Role of Intermittent Fasting in Parkinson's Disease</a>  <font color="#6f6f6f">Frontiers</font>

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Mitochondrial metabolic rescue in post-COVID-19 syndrome: MR spectroscopy insights and precision nutritional therapeutics
Frontiersgeneral

Mitochondrial metabolic rescue in post-COVID-19 syndrome: MR spectroscopy insights and precision nutritional therapeutics

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxORzVDbW1IMDFlaVY5ekNGeExUN21EZl9IazBhNk9VYldWdWwwWmFybklBQlFteERJVkNmbWxEdG9GWHY3RGFYSXNKWWE2QjNad0loTUozbU1QTmhzLTlweW1ob1Y0aks0M1NBOXJYQlhzUmxZalpXODRreU45Y2xaODhvU3V5a1NLMWFiZ19vS2Rkdw?oc=5" target="_blank">Mitochondrial metabolic rescue in post-COVID-19 syndrome: MR spectroscopy insights and precision nutritional therapeutics</a>  <font color="#6f6f6f">Frontiers</font>

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Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis
Naturegeneral

Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1ZLUtKYks4MFpxMEtoZXJFWUdFVWVRZWNncG16RjBuVVhndWRMTlpjZmdsUFNxa1lZZVEwZVNIblhoQlVBbzVHZ3pPWWFJVk5CazR3UTNnQU5vVGtaTU5J?oc=5" target="_blank">Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis</a>  <font color="#6f6f6f">Nature</font>

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Underlying mechanisms of ketotherapy in heart failure: current evidence for clinical implementations
Frontierstech

Underlying mechanisms of ketotherapy in heart failure: current evidence for clinical implementations

<a href="https://news.google.com/rss/articles/CBMilAFBVV95cUxOdl8tZmZ6NEVyMnVSVXJMSGxFMmd1TnhvVG9Bc0R6UHZaa3c2dUlVNlFHN2Y0UXBtb1BLUHMtUWFVbHBkTFZaai1lSEhobl9ucEhWSDB3bU9HRllfdnNoUy16LTFUOTNZY21WUUxuMk9jSGVzUDZYTUtheTdFeHB1VVA5ei1icnE2dE1QelI3b1E0c080?oc=5" target="_blank">Underlying mechanisms of ketotherapy in heart failure: current evidence for clinical implementations</a>  <font color="#6f6f6f">Frontiers</font>

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Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction
Natureworld

Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBsVUJrcDl2ZndSZHpXTDVhd3JZMGw1S0NielNSU0ZGc1FTNEl2RTZveGhpRDY3a2oyOUpZeldxeUVNNHVneElSOXEtSW9CUmdEOHdaTk9aMm1Ec0pONlVR?oc=5" target="_blank">Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction</a>  <font color="#6f6f6f">Nature</font>

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Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model
Frontiersgeneral

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

<a href="https://news.google.com/rss/articles/CBMikwFBVV95cUxPRDZ4MnhLc00xNzRHZHc1MmxyYzMxMDdlZHVnVUEzdWszUm51XzJzVFJuMjg4X2xOeUgyMXZYRHo1UWtvSnNtU0trUl8xUDlMaVFCWFBmVnJQRXI5X2xMSktyUkQ4aXZOV1phTENsckVFSTJralpFdHpaNVd6UDRSLVduMU9PWFZyVGoyeFg1WmFkZVk?oc=5" target="_blank">Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model</a>  <font color="#6f6f6f">Frontiers</font>

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Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma
Naturegeneral

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma

<a href="https://news.google.com/rss/articles/CBMiXkFVX3lxTE9kM3pKbHFoWDA4ajR1U2VEdjJDN0h0WEtpMEhnU2tWb3Zac0tETmFMNHV0eFVxVVlkOU1LZmpFTlFlaW5jVTNYVl9EX1dMbkRjZVVDdW5wQ1VQWXZaWHc?oc=5" target="_blank">Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma</a>  <font color="#6f6f6f">Nature</font>

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Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism
Frontierstech

Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism

<a href="https://news.google.com/rss/articles/CBMikAFBVV95cUxNME9FamVicHVFbmhxbkhrYTRHaDkxa3MycEJqZlhCT0s0UEJLdnc3XzAzMFU0eFFsNEd2MmJaRkdidk5OQm1QNTVOMjVuSmFpMmZCQVV5eWU1b0JxSGt5Wk9mWkgwTVYyOFZZT0E4ZDQzOWJmc3lqVjkwVFB0ZDVGWUYtWlpFU0w3YnViTU14bWo?oc=5" target="_blank">Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism</a>  <font color="#6f6f6f">Frontiers</font>

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Targeting gut microbiota for diabetic nephropathy treatment: probiotics, dietary interventions, and fecal microbiota transplantation
Frontiersgeneral

Targeting gut microbiota for diabetic nephropathy treatment: probiotics, dietary interventions, and fecal microbiota transplantation

<a href="https://news.google.com/rss/articles/CBMilgFBVV95cUxQakVZTFBHZzU5aGVaSkc5OU1teTEyR2RVUHFuc2g0LUtOQ3JtTG9xNVdMQlpiOTBLdVZ0Q3N2S1ZwT2kyWHZZUnVXdURuTzJiQWVZMWxqQm5Jb3RJSURmam9BMFNTMnpNYllRNGtfclhYUDVTSHFuNm81LWtaYUFYalZMM0h6R25PcXpxVnR5Ni10elBkaVE?oc=5" target="_blank">Targeting gut microbiota for diabetic nephropathy treatment: probiotics, dietary interventions, and fecal microbiota transplantation</a>  <font color="#6f6f6f">Frontiers</font>

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Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters
Naturegeneral

Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBFenRmQjBFcllyS05xRzdub1FrZkdsVU5RdXFMTWN4Ym5ua25oZ2dCdzQwQWpxZ2ZPRHJQSzJleExhNG5ZOVRGeThzT05ySTR4c2ZkUzB5NHVKUXZjZWJn?oc=5" target="_blank">Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters</a>  <font color="#6f6f6f">Nature</font>

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Aberrant branched-chain amino acid catabolism in cardiovascular diseases
Frontierstech

Aberrant branched-chain amino acid catabolism in cardiovascular diseases

<a href="https://news.google.com/rss/articles/CBMioAFBVV95cUxPZXFhSGE4eFQ4TlJ4T2w4VTktdjlNWENsNjVyekhpc3lIWHQtY1BManRra2V5YkdhUm9kRlJNNGtMQ2tGTnlyZkhyUGxKX1VzNDlQX0RFRlZIcGRkTDU3NlplOUxoSmVIaXNiZWpKWkU3VEphYXF4WmtSWW5KekR0S3lyUkttODhZa3Jwb0NVWkZRZkFwSG5ObWx2Ny1jNHN3?oc=5" target="_blank">Aberrant branched-chain amino acid catabolism in cardiovascular diseases</a>  <font color="#6f6f6f">Frontiers</font>

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Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer
Frontiersgeneral

Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer

<a href="https://news.google.com/rss/articles/CBMijgFBVV95cUxNa1FjdDdhMmpydWNvZEROamV1dFhZWXRXWVFsU3RVLXVPU0sxWUl4cGF2S1RSN01FR2N2NlZpU2xjSzBjUXp1Y0tKRzRoSHdqSmNjMTRiS0dUbGF0bXIzMlZzSzRBLUxLSTI1TzBTZDBYeklKNUlfOTFXek9xX2h2cms1UVN3LXg3Qm9lNEln?oc=5" target="_blank">Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer</a>  <font color="#6f6f6f">Frontiers</font>

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Metabolic regulation for the treatment of ischemic heart disease with stem cells and extracellular vesicles
Naturegeneral

Metabolic regulation for the treatment of ischemic heart disease with stem cells and extracellular vesicles

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBQaXRaMld5OFE0VzNuaXVOV053WHkyTlNzZno2SVZmTHY3dnI4UHNVeFF2R0V4NTRhM3Y5YVg2ZVdiaTdkeFppWVp1aWgtZlFoWVZLLWxBelR5YzNyN0N3?oc=5" target="_blank">Metabolic regulation for the treatment of ischemic heart disease with stem cells and extracellular vesicles</a>  <font color="#6f6f6f">Nature</font>

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Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
Naturegeneral

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFB5Q2VwQ3JrNktoS3l2VWpMY2FVTnM4NXBuOTRHS1dMMEpILVNKUWQtLVBYbC1iQWZHbXBkVkE5d2VaVjk2Z1d2X0ZUQjJWd3dPckJqZDM2SGowSXQzdVZF?oc=5" target="_blank">Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase</a>  <font color="#6f6f6f">Nature</font>

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The Role of Metabolism in Heart Failure and Regeneration
Frontierstech

The Role of Metabolism in Heart Failure and Regeneration

<a href="https://news.google.com/rss/articles/CBMioAFBVV95cUxNUC1POUlncUZucWV3OE1DVnQwUUJFU0kwbE5Vby04X0ZEQWpuUDIzanJBWTdoSzhmbk9LaFpnXzU1U2ZZdDNZS2lpaXBlSVotSWRBY1dRcVR4c3kzdXJPVlY2M2dUcTdzVElrZk8xeFh5Q3lJWTdiVWtoTHhlS0E5Ukh4YlVBOEczUklzWmJMOVVBSDFUTzRDNWR1ZjU3N292?oc=5" target="_blank">The Role of Metabolism in Heart Failure and Regeneration</a>  <font color="#6f6f6f">Frontiers</font>

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Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species
Journal of Neurosciencegeneral

Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species

<a href="https://news.google.com/rss/articles/CBMiV0FVX3lxTE1hQjY2V3lWRzI3Z196QUhmTmtiQTZNaTVuVUUtbFVSTVdqMDB2RDdjRDZkY2pDWXQ5d0VheUdlSjhIY1pEdXA2Y3R3Q2kzcVYxZ3lfNWtPQQ?oc=5" target="_blank">Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species</a>  <font color="#6f6f6f">Journal of Neuroscience</font>

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"Targeting mitochondrial α-keto" — Live Google News Trends & Headlines