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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Targeting an allosteric s" (30 stories)

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Molecular basis of allosteric regulation and pharmaceutical targeting of protein kinase Cβ
Lead StoryNaturegeneral
May 21

Molecular basis of allosteric regulation and pharmaceutical targeting of protein kinase Cβ

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9PQmJKanRCUWtFcmE1UXVCZHNUZDVlTXlUdWE0OTE4TmZneGNpaU51dHBHREZvaWZyZmVJTE43dDVTZGxETUVMUHlVb2ZCSXAtZF92bVFGb1c3WWFqQjFZ?oc=5" target="_blank">Molecular basis of allosteric regulation and pharmaceutical targeting of protein kinase Cβ</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "Targeting an allosteric s"

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29 stories displayed
AR using antibody fragments targeting the third intracellular loop
Naturegeneral

AR using antibody fragments targeting the third intracellular loop

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9fUXVWUjktaWxxMDlSOVhLOTNLUktmVVZTNUpVYnFkRjdFTm1fcUI5VktIWWN0ek91aXkwTURlcVZBeWkwOXVraEpUM1AxSmFzWU83NlpVazVNR2hwN3FZ?oc=5" target="_blank">AR using antibody fragments targeting the third intracellular loop</a>  <font color="#6f6f6f">Nature</font>

The allosteric landscape of the Src kinase
Science | AAASgeneral

The allosteric landscape of the Src kinase

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBsVXFoZUZXWV9YTkpGTmdISVBqS0REbkEyMV9relcwc2RHNW1HMjZnbnQxR0twY3dDTGYzOUpGREpqa2pabHFDMncyRVJ5TUdMZ3BNSXZJal9mZG01UGxN?oc=5" target="_blank">The allosteric landscape of the Src kinase</a>  <font color="#6f6f6f">Science | AAAS</font>

Targeting PIK3CA With Allosteric Inhibitors Is Promising New Approach in Breast Cancer
OncLivegeneral

Targeting PIK3CA With Allosteric Inhibitors Is Promising New Approach in Breast Cancer

<a href="https://news.google.com/rss/articles/CBMitgFBVV95cUxNR3ktWGFzaFpYbWhFTS04b1JaSk1JQ0M1VVd3QkxmR2FTZnplcnNzTVBJRGNkYjlFZWF0cjkxWFNldWdEVkRBSnRRMmtxUDZwN3RBRjB3QVdHd240Zi1hOTRFZVhMajVwMm1BQ3A1WlFHN1NvRmNMOGRiY0k2U0I3aktTTE9HOEJaV2JmNkpuQUhWLUdLZzM4MHgycTNZTDhCYjJhbHJNMWNvYk9iUEhKODV0amhpZw?oc=5" target="_blank">Targeting PIK3CA With Allosteric Inhibitors Is Promising New Approach in Breast Cancer</a>  <font color="#6f6f6f">OncLive</font>

Allosteric modulation of a human protein kinase with monobodies
PNASgeneral

Allosteric modulation of a human protein kinase with monobodies

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE5wX2dmc3VDekZndFBiQlBEa1lsZEhTMEZ4cldnZTdLUGJZb2pzdnFySU1vUE9ib2NQYTdkVWJTZy04TWlDRmxKOEY3Zlp3d3FlYmZFZEZyQXNsQ2M2?oc=5" target="_blank">Allosteric modulation of a human protein kinase with monobodies</a>  <font color="#6f6f6f">PNAS</font>

A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects
Naturetech

A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE4tMC1kaXVZQUNPbWdkeVk1S09wTFVBaW1JQ0VPRy1fWjlrMVFOUHdKR0xSb3pCWTBBZUxTVFViZndYdW9yaFF0Y09TLVl6OE1GclhvSk4yajh5S3ZUYUUw?oc=5" target="_blank">A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects</a>  <font color="#6f6f6f">Nature</font>

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex
Science | AAASgeneral

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBZVEk3SFdBd3ItWmVqV0NPN1FVM3BkWW85ZE1DUVhjVVR5bkNlQ0ZBSXFuQWNPTlQ4X3htUTJnaGZKdUI2R0pkV3NSWkRzVUV5b0dHNGh2U2dyeFlTRWpJ?oc=5" target="_blank">Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex</a>  <font color="#6f6f6f">Science | AAAS</font>

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7
Naturegeneral

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE8yMXRUMV9waWh1UkZudnJtNldWQ2xMa0V2enlKS21GTnZYZXoyR1I4SHV6MzRaeVhFRWxHOElLa1lXMGg0ZlJPNHB0WTFtbGl4Qnh1SE1TbTQ3ZEtiTmxR?oc=5" target="_blank">In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7</a>  <font color="#6f6f6f">Nature</font>

Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction
Natureworld

Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5wZC1tZnhsclJkck5iLVI2T0x4VC1PbHlYWDl4dTcxNkU4cFI3eUNGRG5tRHNTUE5GUXhMU01RMm5rVFUzek1lOEhtOFZzNnctRllEMS1FQzNORXMzeGtV?oc=5" target="_blank">Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction</a>  <font color="#6f6f6f">Nature</font>

De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS
Naturegeneral

De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBuRWtHSDNDN1JITDYwLXhDM0xVLTBzWTRpSk5ldkhQeGVKcUYtaXNSaUVnTVY0V0dDVkFwQmZHQWtIOFVaT2QwaTJ5M0NobmhZbVZReFh4cFpfVEdJWXY4?oc=5" target="_blank">De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS</a>  <font color="#6f6f6f">Nature</font>

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site
Naturegeneral

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE0yWUJYY0pKRTM5eDhpbXNUSzFuU3lZekRBVXRoRW1haTVrU015LWxXMXo4WVNPNEx3M1N4QmxzNXRsc1NhUzd5b1hiSmJmTDNydjF6bzNWVkFSWHJzdXVJ?oc=5" target="_blank">Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site</a>  <font color="#6f6f6f">Nature</font>

Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach
Naturegeneral

Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE8xbzhXbVQ2dDk0R3BjY3hkWTVNZnJaejRpT3BFYXg3UjhzaTVxQUdEN2VTbGxoWU81blFYMmM1WE1ZcnpCMklLRDJDcXJaYzRsbHhFMG9lS2I4T3F0d1Zn?oc=5" target="_blank">Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach</a>  <font color="#6f6f6f">Nature</font>

Inhibition of RAS function through targeting an allosteric regulatory site
Natureworld

Inhibition of RAS function through targeting an allosteric regulatory site

<a href="https://news.google.com/rss/articles/CBMiWEFVX3lxTE9Rd0hhbE1PSGVMaWlSSWYxeW80SmlRN1NjWG5yUDZCSWlJajhfQTZDNk9wV1NadU50WS1VS1k1NTdlYUVTQi1nYk0xU0t4X21TdEVjQzJVTm0?oc=5" target="_blank">Inhibition of RAS function through targeting an allosteric regulatory site</a>  <font color="#6f6f6f">Nature</font>

Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia
Naturegeneral

Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE52UnhsOE5Fa2IxZ2lvWFBScHJqWHVFTUdzNmhfWUpvLVBSdEVEN3hBaHd1RlB0NmZyMmJYUEZtSnJqLWhrOVJpUWtJdVA0UGdhRnBuYldUTG81MXRvUV9F?oc=5" target="_blank">Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia</a>  <font color="#6f6f6f">Nature</font>

Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions
Naturetech

Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ReTAxSk9WYV84YWtXaXRpdVVLS2djUU45d2hfZHYtRDJtQ01rZ3RxaUlIRlVCSktCcTlfZHQ3YzF2OVFCdUJzdms1aVRlUTdzaWhCZ3NObGpxOVdQN0xR?oc=5" target="_blank">Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions</a>  <font color="#6f6f6f">Nature</font>

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Natureworld

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1uSWc5WEV3RnlOcGFhTi1WSnhFWUJpZzZPUEw4akxFM3V3dzdlT214UF9zQjh2SzdHNExPX3pZbWg0NVJOdW40aFI1Y1VXY1JCTjRyWEFhelc1WjFtZWJZ?oc=5" target="_blank">Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials</a>  <font color="#6f6f6f">Nature</font>

Targeting S -adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A
Naturegeneral

Targeting S -adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A

<a href="https://news.google.com/rss/articles/CBMiWEFVX3lxTE1NdzQ4alpUM0VoZGprTjVoX3gxZ0dLN3dma2FobGo2ekVjOW9mQVVGUTRzcUV4MGdRcmtQUDh6VDBybVpYWm1MUWU2c1o5d2s4aTlQbElzSy0?oc=5" target="_blank">Targeting S -adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A</a>  <font color="#6f6f6f">Nature</font>

Molecular mechanism of allosteric modulation of opioid receptors
Naturegeneral

Molecular mechanism of allosteric modulation of opioid receptors

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1Pd0QxUThteVpOS29Vem5qc1B6bFZoSV9hYllIQUFnTHB1RGZOd0J4dGFabGpSYzJBaXpoeWxYQU5FQ0g2ZmpBZ1haQ2stSDNvblZ1STRfQjB6MV94RVBz?oc=5" target="_blank">Molecular mechanism of allosteric modulation of opioid receptors</a>  <font color="#6f6f6f">Nature</font>

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
Naturegeneral

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9LblZfeExsU2FzU2dxSmhlanh1cFpGSzhQaXMyV3E5N0JWNXpUdENkVlU1NGpwS1Z3bHVXTzByeDczdXFEblBGck1NSFZCTFR0N19TZUpqZ0JtM0x6QlNj?oc=5" target="_blank">Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms</a>  <font color="#6f6f6f">Nature</font>

The energetic and allosteric landscape for KRAS inhibition
Naturegeneral

The energetic and allosteric landscape for KRAS inhibition

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ZZWR5OGFJUFQwQmxtNG5nbmpENWZOV0wxSmZUaDc0T2oySklUOFJ0b0JXR2pZMVJBTXBGam5LMGl1RWNnQlFuZTRGVzZUWHBVQWstLW9YaS1naG5pQnlj?oc=5" target="_blank">The energetic and allosteric landscape for KRAS inhibition</a>  <font color="#6f6f6f">Nature</font>

Designing allosteric modulators to change GPCR G protein subtype selectivity
Naturegeneral

Designing allosteric modulators to change GPCR G protein subtype selectivity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5RSUZGcVVuMkllV0RkcVJDTkluUXhaam9aS3FUbjlPcEZrR01UTWg5QzloeFJfVE02R3hjb0lFMkdUdGZqZ0U2aFdIRjVLcE54OTk2ZXMyWnNobFJ4VjdR?oc=5" target="_blank">Designing allosteric modulators to change GPCR G protein subtype selectivity</a>  <font color="#6f6f6f">Nature</font>

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca
Naturegeneral

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBiT1FURUh6c3FNUG5hOVAxTi11UVlDZkN3N2VHN2xOT21qVEVEelhmem9kTk90aV9RdmZlQms4T0lqbWdjNW9ONHJCQ3BYOWJJaktoeGJlYkROdkJEMTlR?oc=5" target="_blank">Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca</a>  <font color="#6f6f6f">Nature</font>

Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
Naturegeneral

Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFA5NVZ4X0VhakFkdl8xalMzRUZEOUpZNl9PMGs1eVhuQVZjQWppdzRiYjNSdVU3Zi1sTGtIc3FlR2hrRDlSc09RWm92REY5NExLUmxDR3hUdHY0Tk9wOHZ3?oc=5" target="_blank">Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding</a>  <font color="#6f6f6f">Nature</font>

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design
Natureworld

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5LVDFqSTlDZm16cF83SkFLa2xmQ0tpQ05OaV9nRm1VdWVZdUxRTEJ1NWprV21zQW1ZTnI3cGdsbGs2X3BGQ2hZT3Q1Y211SnpNY3BoNXNKX3UwVHRXZm1n?oc=5" target="_blank">Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design</a>  <font color="#6f6f6f">Nature</font>

Decrypting a cryptic allosteric pocket in H. pylori glutamate racemase
Naturegeneral

Decrypting a cryptic allosteric pocket in H. pylori glutamate racemase

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1mbEZfLVB5MUlwX3htNkFHNF9qWGlZWmoyWHB2SWlrSGxMWDY4c0Vram9vMEZxR0ZtV1BvMzF4S3RPdHRia01SYktfNlZhMnFUbmdlT0tyOXVpTGNrT21Z?oc=5" target="_blank">Decrypting a cryptic allosteric pocket in H. pylori glutamate racemase</a>  <font color="#6f6f6f">Nature</font>

IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
Naturegeneral

IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE0zVFF6SWt1NXNFQnBXMWRiaDBQRnkyTEdmRG1KbWpQZzlzN0xYR2dnRWIzTER1bGZwMFhLaktCb1cyWmoyajhQb2NtV2FOSHA5QWhMU3pnc29IRjI0SGJr?oc=5" target="_blank">IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex</a>  <font color="#6f6f6f">Nature</font>

Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR
Naturegeneral

Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1VQmRQeEpJMG5Celh1bllKeWw4b2h2b3lXZHVOcnBpc096RXgyd0VIcFQ5Y05BX1RRd2NZbTF3ZDFxbWhXV19NMjJWaEQwOGJMWEdtdk9OLWlmYzZlaldV?oc=5" target="_blank">Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR</a>  <font color="#6f6f6f">Nature</font>

Discovery of a First-in-Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity
Wiley Online Libraryworld

Discovery of a First-in-Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

<a href="https://news.google.com/rss/articles/CBMicEFVX3lxTE9YRGhnY1ZzUG5veDRfUFNYTjVrUVA5UFNpVjRBc3NqSXo4OTJQWXV0aUdEYmp2U192YkpjWEc2LXdDaHp2Y2NRNTdTbGQwQnB5NDRQNFctX3g3MHcxN0VKOXpybDJ4SHlmRzJDVGlwcjM?oc=5" target="_blank">Discovery of a First-in-Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity</a>  <font color="#6f6f6f">Wiley Online Library</font>

Application of chemical similarity and bioisosteres to find allosteric inhibitors of type 2 lipid kinase γ
Naturegeneral

Application of chemical similarity and bioisosteres to find allosteric inhibitors of type 2 lipid kinase γ

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE54Z1ZtZUxmME1pV203enEwNG9KS05rb2VIakpvcmNNSV9qX21lakhNQk8yRzI3NHBkZlRDc2o0bE9SN0lkRW9GUXFscExIelRwWXdMTXM4d2hYT2hpTlZV?oc=5" target="_blank">Application of chemical similarity and bioisosteres to find allosteric inhibitors of type 2 lipid kinase γ</a>  <font color="#6f6f6f">Nature</font>

TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
Wiley & Sonsgeneral

TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

<a href="https://news.google.com/rss/articles/CBMidkFVX3lxTE84Q3haRE1UNnlsMHhsVVBobmo4RFNMUG85RzZYemRaZzlpaW1jUkZpMjRTZmUzVTNnd1BGMl84SmxheDNhMEZ4WDNyWnFXakVjcmFaNG5pQVVFT2o0MTJCRXV0LWJsUjk1TnVXSjNuaFBXSWxEUXc?oc=5" target="_blank">TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition</a>  <font color="#6f6f6f">Wiley & Sons</font>

"Targeting an allosteric s" — Live Google News Trends & Headlines