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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Structure-guided design o" (30 stories)

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Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent–resistant acute myeloid leukemia
Lead StoryPNAStech
Apr 12

Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent–resistant acute myeloid leukemia

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTFBhQjdnT2hGVHFINkZUOWRZMzZ2OU50bGd3R2pwVUFReUFIQ0h0N1hKZTNkWmJrZ3kweHhqdWY4RGZMSW5vSkFZVkRLaGJab29abVNlcjh0WHZfem1L?oc=5" target="_blank">Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent–resistant acute myeloid leukemia</a>  <font color="#6f6f6f">PNAS</font>

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Search Results for "Structure-guided design o"

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29 stories displayed
Structure and evolution-guided design of minimal RNA-guided nucleases
Science | AAASgeneral

Structure and evolution-guided design of minimal RNA-guided nucleases

<a href="https://news.google.com/rss/articles/CBMiYEFVX3lxTFBmTEV3eGRNcnlsME1yN0pwSGdaS3V1LVB4Mm1lQjhqT0dQOGVnMVQ2NnlJR1RKTThlWGIyNW45bDN6MHZiZ0tRSk9GbHAtbWhkaWlSaDk0TmN1YURTUjE1bA?oc=5" target="_blank">Structure and evolution-guided design of minimal RNA-guided nucleases</a>  <font color="#6f6f6f">Science | AAAS</font>

Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin
Naturegeneral

Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1RZUJFNHZPbmdlLVgtbU1ZYXVVSlhnYVAzaWw0ZndDdjNHOFoyZHFhOVljb1h1YzJINXN6TWFaZzFuUjJiWWRlYl93UWd4NG9WbmZtVjdHX1NlcFN3Y204?oc=5" target="_blank">Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin</a>  <font color="#6f6f6f">Nature</font>

AI-Designed Synthetic CRISPR-Like Nucleases Show Activity in Cells
Genetic Engineering and Biotechnology Newstech

AI-Designed Synthetic CRISPR-Like Nucleases Show Activity in Cells

<a href="https://news.google.com/rss/articles/CBMitwFBVV95cUxON3FUalZWc1Z5eEFaYUIteWZJbWcxeG1nS1Q5R3BrZWVMV3NET2xRRDhldjRNbTIxLVpIUGhoa1EybUx1WVdrMU5kajlmQ1JnR3BiNlJyZk9TVjFDWWVUVGF0UmE1SkRfR2sybmk4RnI3MEN2bWVOay1kcm5yQ09MZnRIOE5mSk14M3UzdG9uRUtqSHpNYnpSVGc2RFZ5WndnNWh4VWIyTmxSXzFOZzN5YmpDRlBQbmc?oc=5" target="_blank">AI-Designed Synthetic CRISPR-Like Nucleases Show Activity in Cells</a>  <font color="#6f6f6f">Genetic Engineering and Biotechnology News</font>

Structure-guided optimization of N -sulfonylpiperidines toward potent multi-target anticancer agents
Naturegeneral

Structure-guided optimization of N -sulfonylpiperidines toward potent multi-target anticancer agents

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFB4WUxqYkxsUWdTdHFVd2ZaLWhnaFdKZzZKQUtKY211SjhCNFo5MW5zSVA5YnVJTzBFd1RnSEExNmVDOVlkZTVJZzlvcGpWTE80OUpwVE1wS0o3dkF1WG5J?oc=5" target="_blank">Structure-guided optimization of N -sulfonylpiperidines toward potent multi-target anticancer agents</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design of nucleosome-inspired nanoparticles for overcoming pulmonary barriers in fibrotic lung gene therapy
Science | AAASworld

Structure-guided design of nucleosome-inspired nanoparticles for overcoming pulmonary barriers in fibrotic lung gene therapy

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5WV2pkZ2hsTEl4cmpDdDBKVjBhaHFBVmRkVkJUYW9qTXBMckRobEpXN0pGVUZKN3IybmJRT21VSENYM1U0R05ZNG9rVWp2QW5mN3VZRjJ1d21VV3Z3UmRZ?oc=5" target="_blank">Structure-guided design of nucleosome-inspired nanoparticles for overcoming pulmonary barriers in fibrotic lung gene therapy</a>  <font color="#6f6f6f">Science | AAAS</font>

Advancing PROTAC therapeutics through chemistry-guided design of smart delivery systems
Naturegeneral

Advancing PROTAC therapeutics through chemistry-guided design of smart delivery systems

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBCWUJZS1FOX1hNTmRoeDR3aXgzQUhNd3FHMFhkSjdGSVdFOWhaZkl6RnE5cFRCMk9ENm5SMUd6a01sTktrcmRmNzRzNkpvYjdIWUxGY1VackdvUEE3NlpR?oc=5" target="_blank">Advancing PROTAC therapeutics through chemistry-guided design of smart delivery systems</a>  <font color="#6f6f6f">Nature</font>

C6-ROMP Enabled by Structure-Guided Monomer Design for Chemically Recyclable Polymers
Naturegeneral

C6-ROMP Enabled by Structure-Guided Monomer Design for Chemically Recyclable Polymers

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5OSUlxbUh0N2hTSFJXckpudUJNTGlkWC0tS3U2LXVQa29UR0ZKSjBodlVpRkRhbW9wSXY5SzNVaTlkblY0Q0J2ai1QTTRYdm94VXJtdkFicHUyZmZScmhB?oc=5" target="_blank">C6-ROMP Enabled by Structure-Guided Monomer Design for Chemically Recyclable Polymers</a>  <font color="#6f6f6f">Nature</font>

Machine learning-guided design of energy-related catalysts from nanoparticles to single-atom sites
Naturegeneral

Machine learning-guided design of energy-related catalysts from nanoparticles to single-atom sites

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1udGh1ZEd1cDBFTmZwV1JSYU9ycGxPLXhEbjZkbUxpV2REWlRKNVRZVHBROElIT1dFb0ViWE1ia01TT1o0bUtGT1UtekZEOHBjZEhTaGhEWFRiRWl5YXBV?oc=5" target="_blank">Machine learning-guided design of energy-related catalysts from nanoparticles to single-atom sites</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo
Science | AAASgeneral

Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1VV2FidjFXX0EwWUhwT1JwMms5VVpKakxfZUxYOEprQ1pOT2R4cFBHQnZ6Z1NpY09QNzhmcjltTmZDUFhjVElwR01CdDF5RGJadGl6dUhNeDhGMHRLc2VR?oc=5" target="_blank">Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo</a>  <font color="#6f6f6f">Science | AAAS</font>

Structure-guided design of partial agonists at an opioid receptor
Naturegeneral

Structure-guided design of partial agonists at an opioid receptor

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ETVViM2dxaXlZNHhIa3c3aUNwVjV2YUNlWTFta3ZKdDZhNmhPN2JZdlNMaHFPVWFzVHpQV2tyTDVfWlJsaF9TeVpSeDIwdTR2LXBpcG9Kek9Wb28xMWhJ?oc=5" target="_blank">Structure-guided design of partial agonists at an opioid receptor</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity
Naturegeneral

Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE8wZ0dvMGhOVko4VXZjWmNOS0hxa1lNUUZJbUJZUzAtVjNXdzIzd0lVTDhsUnU1LTFLMFo4QXZWMXVWc1BMZDZZcEQtbFBEMDBuRDZxNEpLVGlDa19WckhZ?oc=5" target="_blank">Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design of endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing
Naturegeneral

Structure-guided design of endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5nY3V2ZlpJRnRWUm1IZ2JnMFBmcFh1S3l4S3VtSHNwMHkycjFMd19tTlVTS3Ayd2xZMHRINllmaUV1RVlVUS12UWhfUTBVY3R1SE5zcDBnSVpEZmhpUWVB?oc=5" target="_blank">Structure-guided design of endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design of a novel, stable, and soluble Cecropin A variant for antimicrobial therapeutic applications
Naturegeneral

Structure-guided design of a novel, stable, and soluble Cecropin A variant for antimicrobial therapeutic applications

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9LZEQ4c3JXa0UxQm9aYk00RnFPVXJTTXhpczIzRmZjYVhKWUlSRTZ0ZHgyZW40MVg0d3dCeXJjWlF0MXlkQlJnc2l1VDltYjB5MW5QMnk2czNrbWZqUFVv?oc=5" target="_blank">Structure-guided design of a novel, stable, and soluble Cecropin A variant for antimicrobial therapeutic applications</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
Naturegeneral

Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1nUHJGdGp1RXlDSG41bDZITXVGRGVaOFBWUGV6d1BLWVozbEJEbFRSdHhYdTZOc05rWDRtN2o3NG9DbkE5ajM5SEhvN0ptZ1cwUmhWbXJVejBGeEI0R3BZ?oc=5" target="_blank">Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design of a prefusion GPC trimer induces neutralizing responses against LASV
Naturetech

Structure-guided design of a prefusion GPC trimer induces neutralizing responses against LASV

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBrM3h5QVhPaUM4N18zNXp2c3hmTkZTZEVGa3lqaGdnbDhEWEhuc09UbGdZWXZFY1NKVU1KMm5GWmVxTU5TVUNVZ3ltQlVpX0RVMGFraDlhY3dUeUtyQ2lB?oc=5" target="_blank">Structure-guided design of a prefusion GPC trimer induces neutralizing responses against LASV</a>  <font color="#6f6f6f">Nature</font>

Regulating the N -oxidation selectivity of P450BM3 monooxygenases for N -heterocycles through computer-assisted structure-guided design
Naturegeneral

Regulating the N -oxidation selectivity of P450BM3 monooxygenases for N -heterocycles through computer-assisted structure-guided design

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9lQ1AxZXc4Zk1IMlZkaG5RcmY1c0o2OTBiR1JzblBCYm5zSmkxQVo5ZTJFUzR0SVBZZWEyY05VZ2pmV2F1N1RENTVrNlk2bk9SWEUwNENGaWFvRGgyUWVn?oc=5" target="_blank">Regulating the N -oxidation selectivity of P450BM3 monooxygenases for N -heterocycles through computer-assisted structure-guided design</a>  <font color="#6f6f6f">Nature</font>

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution
Naturegeneral

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1ERF9GYnZPLVBJYjN1ejB0VGFpQjF6ZEhldlhGT0sxQTJaWGVpbEE5ZkVoR2RERjliYjNsdHlWMkQzdm1HNXZVclpuT1cyMldnZ182eHFWZ1YweVhwaEU0?oc=5" target="_blank">Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution</a>  <font color="#6f6f6f">Nature</font>

Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
Naturegeneral

Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFA0REF0aWU2SHZWUy0tTFVqc1JoVTdfOEJTR2tvTmM3QVdtWkItVzVRb3o5MFNacksxVFJHNUdtSDZHcWpnMlpVSEJkQk14TnRIVUxFYXNjcWNCWEtwUGw0?oc=5" target="_blank">Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
Naturegeneral

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5maU5jdm0yMHhBOXBLUDFVUElHMkx2MEpQOGltdTNRbFVldUpLVkw5OXpwaF96THYxSjVCdHpHakctekY1VW1lZzhwbHppSW5XR29lOWRTdW1KTXdBUURR?oc=5" target="_blank">Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor</a>  <font color="#6f6f6f">Nature</font>

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Naturegeneral

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

<a href="https://news.google.com/rss/articles/CBMiU0FVX3lxTE5FMFVlVUcwNHp3aEN4RnlCV1Btb2ozYnRadGlnSkROWXZtck45Ti1UX3Rud1Z2UG5HUmhGczQ5OW02TVhNRGNSSVg4Y3RqcE1HWWFJ?oc=5" target="_blank">Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists</a>  <font color="#6f6f6f">Nature</font>

Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism
Naturegeneral

Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5UQkhkRmxXcDlBamhCMXJPR1o1NzRpTWZ6VEdOYTlhRTlOZDN5ZGNua2lDVGZ4UHRsQkhidFNWR2xxNzhTSnhHa2xpTzZRekFwQ0x1N0pSdDNjbU1aZ2o4?oc=5" target="_blank">Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism</a>  <font color="#6f6f6f">Nature</font>

Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design
Naturegeneral

Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE50eFdwUnIteXlUZlJ1REJFU2l0Q01ZSHRhenE2YTVwYUgzZktuRkN2NTA1SnlBU0YyV25WeWEwVk82MnM5OXhPUEpxRTVaU2VSNTRTeUpweHJGSkpMNlBJ?oc=5" target="_blank">Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of ( R )-phenylephrine
Naturetech

Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of ( R )-phenylephrine

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE42X1k4MEc0QmRpRmJRa3RBTUhXNE1fZHBvZmc3NHRfWnlTUHJtNTU0V3VNREM2cVhPclJkRXp6YXJSRnhOQS04eE9KOGtnc2djWG9WNkNZY2xYLUNEV2xn?oc=5" target="_blank">Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of ( R )-phenylephrine</a>  <font color="#6f6f6f">Nature</font>

A manufacturability-informed topology framework for AI-guided design of fibrous network materials
Naturetech

A manufacturability-informed topology framework for AI-guided design of fibrous network materials

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBsLVVUM3Bwamt2QzMwOVJFdGlsbGxDNTBpM1Y0ZnBfYzlPNkZQTUItMDZWVGlycmVqNkdCMTVJeHNRSHIzMUR6aHA4R3ozMjEtc2x3dEpVVmVEOXN6VFFj?oc=5" target="_blank">A manufacturability-informed topology framework for AI-guided design of fibrous network materials</a>  <font color="#6f6f6f">Nature</font>

Structure-guided design of a selective BCL-X
Naturegeneral

Structure-guided design of a selective BCL-X

<a href="https://news.google.com/rss/articles/CBMiWEFVX3lxTE5PVGNaV0llVEQ1TlJDaHV0M2c3Vks2eTQxSnhLMFlsdGxPNHAybzBQNDVkaW5ZVzBXRnFpTnlxYWRPSzN0SnowM1p3Mmk3VHBQOVdlSGFWNks?oc=5" target="_blank">Structure-guided design of a selective BCL-X</a>  <font color="#6f6f6f">Nature</font>

Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens
Naturegeneral

Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1oRmRyMVNHVW04eS1VUTVUb0hUZ0J3MDNDdDBpeVRXOWlSNVM1Ui1sWktnbGFrTEd6MlVNaXg5WWswUktTd0ZicUNpekFHYnNIVWljbUY5RzRtYkJ2Y3c0?oc=5" target="_blank">Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens</a>  <font color="#6f6f6f">Nature</font>

Structure- and mechanism-guided design of single fluorescent protein-based biosensors
Naturegeneral

Structure- and mechanism-guided design of single fluorescent protein-based biosensors

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBhc0FsaDJqamRmNXF0cldSME5uVDRaclRBMFNwTmtBMzBwVFp0c0pwMHRJcy1XWDhZNm1CcDNtc3J1eVM0TWlNekluNUtkdXdRWUdpUmNSS2NhOXJFSkVz?oc=5" target="_blank">Structure- and mechanism-guided design of single fluorescent protein-based biosensors</a>  <font color="#6f6f6f">Nature</font>

Structure-guided identification of small molecules potentially able to modulate GDF15 activity
Naturegeneral

Structure-guided identification of small molecules potentially able to modulate GDF15 activity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE40MWo1dFJTa041RGFISERtX3NDRHhMT09TTnFWVFZsVm1aMFh6cElRX3N4N0dZMHdjNlRNS0xVbmF5aGRNVE0zaWVrSzNIZ3ZobmZ1Uk1qM21RcVJDbGQ4?oc=5" target="_blank">Structure-guided identification of small molecules potentially able to modulate GDF15 activity</a>  <font color="#6f6f6f">Nature</font>

Octahedral-motif-guided design of optoelectronic semiconductors via interpretable machine learning
Naturegeneral

Octahedral-motif-guided design of optoelectronic semiconductors via interpretable machine learning

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1Fc0dBeGJUSVI4eXVVVUZxZ3RGQkhXajhsZTJ0Nk1zd2ZRaFNrYnEtaTRCbTZaeXE3LWhQOGRtczN3eUphY0tTc3lzOFpnTlg2SFlpVzBEckFXOTQ3Nllj?oc=5" target="_blank">Octahedral-motif-guided design of optoelectronic semiconductors via interpretable machine learning</a>  <font color="#6f6f6f">Nature</font>

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