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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Structure guided discover" (30 stories)

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Structure-guided discovery and engineering of miniature CRISPR–Cas12m for epigenome editing
Lead StoryNaturegeneral
Sep 16

Structure-guided discovery and engineering of miniature CRISPR–Cas12m for epigenome editing

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9hTWVkVDRUbnk5cUMtbldhejJYZjlWRlphTU9wRzdFcENGcmU0NzJaeW9sckJWd3JsZXJSUFVfRWV2RHVkV0FWZTJ3V2cyNzdqNGJxTG9ReGI1TTBwQ2Rz?oc=5" target="_blank">Structure-guided discovery and engineering of miniature CRISPR–Cas12m for epigenome editing</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "Structure guided discover"

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29 stories displayed
Thermo Fisher's South San Francisco cryo-EM center offers drug developers a proving ground for structure-guided discovery
R&D Worldworld

Thermo Fisher's South San Francisco cryo-EM center offers drug developers a proving ground for structure-guided discovery

<a href="https://news.google.com/rss/articles/CBMi5gFBVV95cUxPdWtpTFJ2M3o2T2xqVktTMVhuNHpsQUtOdFRHYmxQVWN3b3ZnNnp1dGZORHBkR3FrR2lQeThsdWtaMHR4eUh6SHhkMkR4REJPMkxLMlU4V0tYb3dqcjdocTNjMzBtMFRwcmxrUll2NGxwQ20yRTNxQWlUOGlLbXN6S0RyY3FGX3JOVUxEdGIya05XUF9lQ2tDYVdURFJ5cGRINWYwc0JoUGhFZlB3ajdtV193bGxJSEdkOHhGMHo1MXRfZEVCbnlBT0p0cW1USF94dVE4S2NkUHIwbXU0OE14T0JjX0tiUQ?oc=5" target="_blank">Thermo Fisher's South San Francisco cryo-EM center offers drug developers a proving ground for structure-guided discovery</a>  <font color="#6f6f6f">R&D World</font>

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Beyond one drug–one target: AI-guided discovery of multi-target antiviral therapeutics
Frontierstech

Beyond one drug–one target: AI-guided discovery of multi-target antiviral therapeutics

<a href="https://news.google.com/rss/articles/CBMijwFBVV95cUxNUDRQMG9yeU5EQVRaeEVDajhlRXlERzhaNnhFS3o4c2x5NXloLWdFUHppRnp1cEtzM284SEFBQVZSMTNIWnctZnVsZ0xOdGhPUmtUbnhSYXlhNk5xekdZR0Y2M1oxdWMtUlhlaDdVTzVWNlV6VUNRMWhpTG55QjdSMXZZLTFJdDhBOEJNeXhlMA?oc=5" target="_blank">Beyond one drug–one target: AI-guided discovery of multi-target antiviral therapeutics</a>  <font color="#6f6f6f">Frontiers</font>

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Prioritizing neuroactive ligands using motif-guided virtual discovery and zebrafish profiling
Naturegeneral

Prioritizing neuroactive ligands using motif-guided virtual discovery and zebrafish profiling

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBUWUkySG1KbDlkemZaeGRkb0k1SEpySEIwV0xDUGx6clIyTkI1V0MxY1ZHNXNEb29LcXQ0X2JkejhzTlVCa2daMEp6WTRxSEk1TzJ5SlpFb0NlOWlvZWpv?oc=5" target="_blank">Prioritizing neuroactive ligands using motif-guided virtual discovery and zebrafish profiling</a>  <font color="#6f6f6f">Nature</font>

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Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases
Science | AAASgeneral

Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases

<a href="https://news.google.com/rss/articles/CBMiYEFVX3lxTE9RWlQycFVaMFZUVzJFTU5QUTB2eXIwczdUSU5laGxITHJ5bkZfUDFWQ2kyeVh6dC1kSF9OSURIZkZPSW5uNG12c1VHbG5WYWJTZ050M1Zld3ZDMDFrRkNweg?oc=5" target="_blank">Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases</a>  <font color="#6f6f6f">Science | AAAS</font>

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Structure-guided discovery reveals ancient clade of Cas13 ribonucleases
CRISPR Medicine Newsgeneral

Structure-guided discovery reveals ancient clade of Cas13 ribonucleases

<a href="https://news.google.com/rss/articles/CBMirAFBVV95cUxQOWd3aC15Nk4xVDRXbnJ2eERmZVg1UU96TW9UVDlzZDNWeG5pdnBEVFNlaEh6RkVTYU5kSTREanVod09feldDdldNV3NmaFdGUTBRZkxHSHRNdnJiZTEyQXc3SlY0REpmVzdVLWJ4SXpORHFhVWViWVYzWjV1WHAwWWtLa01vUjVUeXNBSXAzNmRUcnpDeFdVZzh2cWlWNUZwY3VHZEU1bGVfT2Q4?oc=5" target="_blank">Structure-guided discovery reveals ancient clade of Cas13 ribonucleases</a>  <font color="#6f6f6f">CRISPR Medicine News</font>

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Structure-guided identification and biological evaluation of reversible EGFR C797S inhibitors
Naturegeneral

Structure-guided identification and biological evaluation of reversible EGFR C797S inhibitors

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5uSEYyZW05dWdmQnBSVzgxbDNFeVdDV0cxUENKYm9VdWJralk2RGtpNmpNajR5YVdiTmpSMzBNcWV1RFp0ZG1MNzZMRFlmRXp4cW9YN2ZJQVB6bmRGZVlR?oc=5" target="_blank">Structure-guided identification and biological evaluation of reversible EGFR C797S inhibitors</a>  <font color="#6f6f6f">Nature</font>

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Structure‐Guided Discovery of a Potent Inhibitor of the Ferric Citrate Binding Protein FecB in Vibrio Bacteria
Wiley Online Librarygeneral

Structure‐Guided Discovery of a Potent Inhibitor of the Ferric Citrate Binding Protein FecB in Vibrio Bacteria

<a href="https://news.google.com/rss/articles/CBMicEFVX3lxTE8xT3htbTlDLUZGNDlzT0Q4dXFuLVJmVWNxYUZhZHJibW1JcUNyVTZXNXBCN09yTVViUzRaWTZjQzdJYWlxWUU3Qnl1aGF3MDUyT0d4Y3hrZVduTEIycWJKUWxBVXNiZGFoRC1Yazh5Zng?oc=5" target="_blank">Structure‐Guided Discovery of a Potent Inhibitor of the Ferric Citrate Binding Protein FecB in Vibrio Bacteria</a>  <font color="#6f6f6f">Wiley Online Library</font>

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Scientists Design Molecules “Backward” to Speed up Discovery
New York Universitygeneral

Scientists Design Molecules “Backward” to Speed up Discovery

<a href="https://news.google.com/rss/articles/CBMixgFBVV95cUxNRjlMckZqMlhjZXp0WEs0eXZWNDk3ZWtHWEFuQnhXeGRVbnRzZHhEMmFyaTdMZFQ2ZExpcVROUkE1U0NRaVAzekRKbmFna1VPME5Nb043WWVYU3RSVUtrUDJxcExpeVJ6bk82MW1IZkRWOWFnSV9wemU1Z2J3QnAzOGRVUTFycTVZRnUtVzVIQ3I3MThta2dDZXBCWFAzMUsxNm96cDItXzNrSl9kSXlYYnBKcG8wUTZuY21GRnBuTERkSkdBMEE?oc=5" target="_blank">Scientists Design Molecules “Backward” to Speed up Discovery</a>  <font color="#6f6f6f">New York University</font>

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Structure-guided discovery of a single-domain antibody agonist against human apelin receptor
Science | AAAStech

Structure-guided discovery of a single-domain antibody agonist against human apelin receptor

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9aSjdSWXZjR3JLbVc4UHhXazdTREkwaW1RMWhYbjFyM01KU1hjalppTFIzY2dUdG9KZkFoZXBscTM2R0ZHWE8wWHRmaWlhdUVwYlhMeEs4VEg4OVFIRm0w?oc=5" target="_blank">Structure-guided discovery of a single-domain antibody agonist against human apelin receptor</a>  <font color="#6f6f6f">Science | AAAS</font>

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Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface
Natureworld

Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9UZFFGS2pWLVh2NTZrOEVURVBJZWRrWDVZdG03ZGU1SzB6V0lrbC1vcFdXc0RCbUlBRjJvV2Ytb09XTmFhbEVFdlA4dGg3UDlfZWR3YzItbDN1Y3hEdTZ3?oc=5" target="_blank">Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface</a>  <font color="#6f6f6f">Nature</font>

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Language model-guided anticipation and discovery of mammalian metabolites
Naturegeneral

Language model-guided anticipation and discovery of mammalian metabolites

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5tVGhHcWdSLUk1OWFIdTFwYjE3RkVSaUItaE9DSmE4VTczQnFHbDVHRC1neDVTaG45S0RQOGRPZXN2dlhENkNpckhjeVZMRnhYZGRnbmwzMTZaalozSlA4?oc=5" target="_blank">Language model-guided anticipation and discovery of mammalian metabolites</a>  <font color="#6f6f6f">Nature</font>

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Navigating structure-based drug discovery with emerging innovations in physics- and knowledge-based approaches
Naturegeneral

Navigating structure-based drug discovery with emerging innovations in physics- and knowledge-based approaches

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFAwODlyaS14N2Q5TFUwUUpxZkVNOGQ2WkU3eG1NVVd1VTJZWTFkTkdMc3k1bW9CN0dsTnR6eHc4dEFTM05qNjYzSjVJdGdOQU94RFI2UnhoSWdqNkFZRkJj?oc=5" target="_blank">Navigating structure-based drug discovery with emerging innovations in physics- and knowledge-based approaches</a>  <font color="#6f6f6f">Nature</font>

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Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence
Naturegeneral

Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE00R1pTdDZKanJLbnVXbGdDeWo2VHZ0ZnE5c096SkhmRThFT210UWxud3NVaGdDRlhPai1Nc0U3MWQ2b3ZUQVlROUMyTUthZVVRbWtZMW5qb3NtdkRERGo0?oc=5" target="_blank">Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence</a>  <font color="#6f6f6f">Nature</font>

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Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin
Naturetech

Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE04X0RJc3JndEJzbExqOTM5Z1ZmN3EzaFdQQzRmWlZNY3NBLVhNMWZlMXRNRV9pWE9fSWhoRERUcExTdWdUclB4TTdMZTVIdmppVXNiOS1XcFhfNzRHOWVn?oc=5" target="_blank">Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin</a>  <font color="#6f6f6f">Nature</font>

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Structure-guided discovery of anti-CRISPR and anti-phage defense proteins
Naturegeneral

Structure-guided discovery of anti-CRISPR and anti-phage defense proteins

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1hc3lWVTVhTnpSM1UwVVg0bUdKdEJxbTJjQXo2VjdXNDU5R3gwSkhwZW9nT083LXZ4d0RLRGw4MGp2LWZNVkdXUWhzblFjM2hqN19HUGlXV24wUlhacmJ3?oc=5" target="_blank">Structure-guided discovery of anti-CRISPR and anti-phage defense proteins</a>  <font color="#6f6f6f">Nature</font>

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Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context
Naturegeneral

Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1FNDdRNEtqNi1XY2h5VEVOMkZGZDI0N0pUZjBSckhkNE5nUzZ3bHdLal9VenN1ZGpfWVZySEJ4QkhYcHlrNzJrUEFPeml0Y1lLUmpzMkNvRnVzRmgxeWo0?oc=5" target="_blank">Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context</a>  <font color="#6f6f6f">Nature</font>

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Structure-guided Discovery of Dual-recognition Chemibodies
Naturegeneral

Structure-guided Discovery of Dual-recognition Chemibodies

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBINWdYOXVNS3FrQkJDeGhldndUX2MyaWttdGtVYlZyN0RfMjh0RHZQT2ZjSUplenVteGU5VHZLSVJWdlYyekV4cnFUUUZZUXFPdE84eTRKazd0cW9FMjhZ?oc=5" target="_blank">Structure-guided Discovery of Dual-recognition Chemibodies</a>  <font color="#6f6f6f">Nature</font>

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Developments and challenges in hit progression within fragment-based drug discovery
Naturegeneral

Developments and challenges in hit progression within fragment-based drug discovery

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5xNmlyUmZORnFlQnBTUHR6clktOU43N3NYTy1ONmNCbFJ5WlRQQ3REcm5sUTFhcUkyVWgzNG9CTklTQkIzb3dRTDM2WjRVbWNTRU5UTnpIWXlrOUJ6V1Nz?oc=5" target="_blank">Developments and challenges in hit progression within fragment-based drug discovery</a>  <font color="#6f6f6f">Nature</font>

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Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism
Naturegeneral

Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5UQkhkRmxXcDlBamhCMXJPR1o1NzRpTWZ6VEdOYTlhRTlOZDN5ZGNua2lDVGZ4UHRsQkhidFNWR2xxNzhTSnhHa2xpTzZRekFwQ0x1N0pSdDNjbU1aZ2o4?oc=5" target="_blank">Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism</a>  <font color="#6f6f6f">Nature</font>

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Structure-guided discovery of potent and dual-acting human parainfluenza virus haemagglutinin–neuraminidase inhibitors
Naturetech

Structure-guided discovery of potent and dual-acting human parainfluenza virus haemagglutinin–neuraminidase inhibitors

<a href="https://news.google.com/rss/articles/CBMiVEFVX3lxTE94RUVBRmIzcURERzJTamRGb3k4eENRLUI3SmU4M2xGYUZ5R2Zud3otSHlsXzlPY1FOT09YZ0hxMmRsLTZBTjI2NmlXaEt3WjB0VjhDeQ?oc=5" target="_blank">Structure-guided discovery of potent and dual-acting human parainfluenza virus haemagglutinin–neuraminidase inhibitors</a>  <font color="#6f6f6f">Nature</font>

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A faster route to active GPCRs
Drug Discovery Newsgeneral

A faster route to active GPCRs

<a href="https://news.google.com/rss/articles/CBMiekFVX3lxTE1jNFJhV0NNZXZjcTZxM2ZvS1doY2FId1MyVFNPclZYcUw2RkFTVjNZS2ZxaENRSkZYanA2a2ZkdkNBcHRzcnlkaHphRkwyTmNUb1BYLWxMOW95aWRyRnRBcXlhWjkwUTZXN2tsY0tGWl9PSkc1ckR0WW1B?oc=5" target="_blank">A faster route to active GPCRs</a>  <font color="#6f6f6f">Drug Discovery News</font>

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CryoSeek: A strategy for bioentity discovery using cryoelectron microscopy
PNASgeneral

CryoSeek: A strategy for bioentity discovery using cryoelectron microscopy

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE53WW9aYjNKVUxJWDM3Q2Y0RzRLX2JTQWItR0F5cUZpZW44WWY2NXFvdEF6STk3cExrQUxkbVJrNGxuVWpkTW1sYk5JZ1lKN2RDMFFkUXhjbGtyLVZJ?oc=5" target="_blank">CryoSeek: A strategy for bioentity discovery using cryoelectron microscopy</a>  <font color="#6f6f6f">PNAS</font>

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Structure-guided design of partial agonists at an opioid receptor
Naturegeneral

Structure-guided design of partial agonists at an opioid receptor

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ETVViM2dxaXlZNHhIa3c3aUNwVjV2YUNlWTFta3ZKdDZhNmhPN2JZdlNMaHFPVWFzVHpQV2tyTDVfWlJsaF9TeVpSeDIwdTR2LXBpcG9Kek9Wb28xMWhJ?oc=5" target="_blank">Structure-guided design of partial agonists at an opioid receptor</a>  <font color="#6f6f6f">Nature</font>

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Protein-structure-guided discovery of functional mutations across 19 cancer types
Natureworld

Protein-structure-guided discovery of functional mutations across 19 cancer types

<a href="https://news.google.com/rss/articles/CBMiUEFVX3lxTE9rVjIzQ3FvYWtCMmY1UlFuamxmQzJ1QTEzN1draEZISTNQSHlfZHhzbnhDeHdBdExjN3JKX3ZmUU1JS0MxZ3BLbnhIZzlXSjls?oc=5" target="_blank">Protein-structure-guided discovery of functional mutations across 19 cancer types</a>  <font color="#6f6f6f">Nature</font>

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WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
Naturegeneral

WRN structural flexibility showcased through fragment-based lead discovery of inhibitors

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ON2tvRDJ4SllpNmxqR3M1endZRnYwUXNFWURJMWlZaFdncEF1NENVbm5YRWhMa1dZWXotbzdSeHRBcDhwbFBKWWZkNVphSVpBSlJYb3lIZXlTWXBNcm5N?oc=5" target="_blank">WRN structural flexibility showcased through fragment-based lead discovery of inhibitors</a>  <font color="#6f6f6f">Nature</font>

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Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity
Naturegeneral

Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE8wZ0dvMGhOVko4VXZjWmNOS0hxa1lNUUZJbUJZUzAtVjNXdzIzd0lVTDhsUnU1LTFLMFo4QXZWMXVWc1BMZDZZcEQtbFBEMDBuRDZxNEpLVGlDa19WckhZ?oc=5" target="_blank">Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity</a>  <font color="#6f6f6f">Nature</font>

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Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs
Naturegeneral

Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBJUGxxemgyYzJ2TWxYbTZsWEZWSUtqZUlyTUtxYk5CcmlWSnpaNnhuMlJ3czdJb2R4ZlBETDdlZGJXSldRc2YxSmxCWHkybVlucDh3cVJ2MFBQNUVRMzNV?oc=5" target="_blank">Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs</a>  <font color="#6f6f6f">Nature</font>

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Accelerating the discovery of novel magnetic materials using machine learning–guided adaptive feedback
PNASgeneral

Accelerating the discovery of novel magnetic materials using machine learning–guided adaptive feedback

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE84aDgtTGZ3TkpCQ1F0MmVSUVRERE1tdUlDbnB6X3g1VnZUSl9tbGpUUm82aU9QbWY1Vi1idXRsNXAxZlkwRFF5QnRWVE4yczVBbDEybHJuNTJtYjJN?oc=5" target="_blank">Accelerating the discovery of novel magnetic materials using machine learning–guided adaptive feedback</a>  <font color="#6f6f6f">PNAS</font>

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NMR-driven structure-based drug discovery by unveiling molecular interactions | Communications Chemistry
Natureworld

NMR-driven structure-based drug discovery by unveiling molecular interactions | Communications Chemistry

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBsLXo5VkYyMF9ad3YzSDdmMi1FS2sxTjdEVzNTOW1IdlFWYTJYOHhjQlB0T0FFZlFmUXQtb0N5YjlEMHFoZzhkRzB1Q084Z1dsU0llNGdXVkwwV0ZBbktZ?oc=5" target="_blank">NMR-driven structure-based drug discovery by unveiling molecular interactions | Communications Chemistry</a>  <font color="#6f6f6f">Nature</font>

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