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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Small Molecule Conjugates" (30 stories)

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A protein–small molecule conjugate as a bispecific inhibitor of proteases implicated in cancer metastasis
Lead StoryNaturegeneral
Aug 3

A protein–small molecule conjugate as a bispecific inhibitor of proteases implicated in cancer metastasis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE00RUtxLTJQcjctNHpWdXd6aTN0bzdiR0hGWEJUcGV6ekd6b1AwWGRQT1dCZG1IY3N6Y2E3VEVUTDBaVWNOWkNuMnpVYmxneWd0SlpmbXNNWlpUZVVsMk00?oc=5" target="_blank">A protein–small molecule conjugate as a bispecific inhibitor of proteases implicated in cancer metastasis</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "Small Molecule Conjugates"

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29 stories displayed
Moving beyond the binary: how the convergence of small and large molecules is reshaping pharmaceutical R&D
Drug Discovery & Developmentgeneral

Moving beyond the binary: how the convergence of small and large molecules is reshaping pharmaceutical R&D

<a href="https://news.google.com/rss/articles/CBMi2AFBVV95cUxQeGUxRGxXN0J6bXpZOHk3SUFRSFRVOUF5OUxqaDB6MS03YVRaZ2E5T3BpSjdtYjNMY2l5YnpORVljLUU5RU5jUEpoT3pqeC1nNlJxckxDVXI0c0RjWDJPb2x1eUpxMTAtRjJ2OXlPcTBRckZoOUVEbVdZREtoY3B3RTl1bUQtcVBobUw4ajVoU1U4WmxsMTVlVUJWNy1CbGxVeXFXSlg1Y2lZQU5ZMV9BcElSWEdYbVRCVVh5TVJVS2RCYWVpRVc3R3RYRDhRc3QyMVZ1cjROMlM?oc=5" target="_blank">Moving beyond the binary: how the convergence of small and large molecules is reshaping pharmaceutical R&D</a>  <font color="#6f6f6f">Drug Discovery & Development</font>

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Chimeric Small Molecule Drug Conjugate Effectively Targets Solid Tumors
Genetic Engineering and Biotechnology Newsgeneral

Chimeric Small Molecule Drug Conjugate Effectively Targets Solid Tumors

<a href="https://news.google.com/rss/articles/CBMiswFBVV95cUxPb3UwWTJRN3FYcGpFWTNrNUVna1loLVhTd3pJVDdtZGpIcmhMUTdOMlRweDZiMzBvSTJiMXAtMVdrSVZBWS1idWVpR21NcGFkckM5aHVWaGltTFItVGdVRnd0TTNCUWJwSlJMSEIxdVI3M1ZXdWZsUzlhYmt4NnBGNktjWG5RTDlQTVpXOTdoQmRFb1JhNHJXUzdPUEVPalpxRTZhOFYwaXF0ZEZST1dheFpIYw?oc=5" target="_blank">Chimeric Small Molecule Drug Conjugate Effectively Targets Solid Tumors</a>  <font color="#6f6f6f">Genetic Engineering and Biotechnology News</font>

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Site‐Selective RNA Modification by Programmable DNA‐Small Molecule Conjugates
Wiley Online Librarygeneral

Site‐Selective RNA Modification by Programmable DNA‐Small Molecule Conjugates

<a href="https://news.google.com/rss/articles/CBMiakFVX3lxTE1neXJhUW9RWDRGNG5LTjk5OF9nMl9TcXY0Z0YwaGZEU2wyVDF1Tjd2SjU3MGFlTXFHc2xCSUNIS21tWGI3TXYwQ0VjS3NHaGxXSENaSXdnN2E4R0hNdUNQQ005NFBUYkRaYXc?oc=5" target="_blank">Site‐Selective RNA Modification by Programmable DNA‐Small Molecule Conjugates</a>  <font color="#6f6f6f">Wiley Online Library</font>

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CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics
Naturetech

CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBPMkFCWVp1cUdSSVdWb2o4MVBkeG8zMVR1eHNkRFFSaTVmd0EyR2RKVHVVUHlKVklnRFNCREhQdWJHOHIxT1ZwTDgyRXJ4VFZqWXFYaVpJMGtGT2VsQURB?oc=5" target="_blank">CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics</a>  <font color="#6f6f6f">Nature</font>

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Bristol Myers Squibb selects Texas site to build $2.3bn biopharma campus
Cleanroom Technologygeneral

Bristol Myers Squibb selects Texas site to build $2.3bn biopharma campus

<a href="https://news.google.com/rss/articles/CBMihwFBVV95cUxPWEp2UVBsakVSSngxUXlqTjRfSFQzMGRSWE10eWFqbmJFNGE2bllxS3VfUjBHR2d5S0NXeDk5cVU4cnFMbHNpam1mdTFQaUVvX1BrYjNESG8tNFVDMXdSVUpmdnI2Y054SG1CcG9RRzdpSnM1NTN4U1hlZUxHeUdyNDZBVHdfdzg?oc=5" target="_blank">Bristol Myers Squibb selects Texas site to build $2.3bn biopharma campus</a>  <font color="#6f6f6f">Cleanroom Technology</font>

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Uniting Small-Molecule and Biologic Drug Perspectives: Antibody-Drug Conjugates
BioProcess Internationalworld

Uniting Small-Molecule and Biologic Drug Perspectives: Antibody-Drug Conjugates

<a href="https://news.google.com/rss/articles/CBMisAJBVV95cUxQTks2a0FQV2EtTmh5MHRycV9HRktSY0E5ak5zNnNlVGhWRlgtclBEcVlNZl9qTlNSUzdWRzdCR2lRaUxPSEg2bzVCMGh6MGFELUhTVnhIaExYV3FHSGNSR29wUWFGVGsxM2ZJQlFvcWpfTEl6MEFEVm45dkphUlBvM1JZLTBTMjNIU1BFQ2lrRW9CTHhoR1RYRHlXYmZfYkFhajJfc1hTV2xqZlJ0cFZJQ1Vabkc0aVByN2I0U0Y1dE9kaWhiQ3hxaVFzdk02WXdtWHN0MUl0cFV5RlhmbGxvZ3B3MVJqWEg2NzI2NURDZ29BZHF0RmxERlVaSlFmMTgwaHBUQUlwQUNCRWF1UVJEeWhPUmRXSzFHa2JJbjc1NGo1Vy1QWkpwNFl2Xy1rQ3ow?oc=5" target="_blank">Uniting Small-Molecule and Biologic Drug Perspectives: Antibody-Drug Conjugates</a>  <font color="#6f6f6f">BioProcess International</font>

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BCL-XL–targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors
Science | AAASgeneral

BCL-XL–targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE8wOV9CRWRVdVZVRWREcGo0LWFDVV9lWGVUWTNDS3hSZHd5UWc1Mks4NF8zUkhwUXp6bVE0UGFBOUpwZmJkTlZGWnVHb1BaYS0tcmFTbzZSRjI4czNka3hF?oc=5" target="_blank">BCL-XL–targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors</a>  <font color="#6f6f6f">Science | AAAS</font>

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The therapeutic window of antibody drug conjugates: A dogma in need of revision
ScienceDirect.comgeneral

The therapeutic window of antibody drug conjugates: A dogma in need of revision

<a href="https://news.google.com/rss/articles/CBMidkFVX3lxTFAyd0ZXRDFWUnEyY2NUZXVHS3ZfQlpjNUxNUlBLVnhDd3I1dzlzNGxiQVVQdlVwYThDRExxZDF0WFVQTTR3M0RleS0yRDl5cFR3eHlnRHNuYUlXRERhQTVsZ2JqblV2R1l6dVRCeGl0UWJUUlRrS2c?oc=5" target="_blank">The therapeutic window of antibody drug conjugates: A dogma in need of revision</a>  <font color="#6f6f6f">ScienceDirect.com</font>

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Strategies for the development of stimuli-responsive small molecule prodrugs for cancer treatment
Frontiersgeneral

Strategies for the development of stimuli-responsive small molecule prodrugs for cancer treatment

<a href="https://news.google.com/rss/articles/CBMilAFBVV95cUxQNFVnNTQtMkp5WUVfbzJWRW5yNzZaZUNJN0FqaU9WYmhDeko3YUdwMXN4WVFMSnVXVjNRRHp1RkpZeElsRV8wcHRJYVR4bGFGTjdYVUFCcHlZRzItVnlRVGdGdDFsZG4yMHB4MFJ1R2hueTJkQ3NLd0dnM3N1VkpKdEVsNDAxd2s4NEtDLVZmdnM0VFlZ?oc=5" target="_blank">Strategies for the development of stimuli-responsive small molecule prodrugs for cancer treatment</a>  <font color="#6f6f6f">Frontiers</font>

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Small Molecule-Drug Conjugates Market | Global Market Analysis Report - 2035
Future Market Insightsmarkets

Small Molecule-Drug Conjugates Market | Global Market Analysis Report - 2035

<a href="https://news.google.com/rss/articles/CBMiigFBVV95cUxQZldpdGJVRDVNbE9JVjFvMjd0OTE5d3lqRTJvUEFHbTBZWGJYTjJ1VmNkbkNOa244b3c4SDJIeVVmeTIwMnY5YlI3SDJucWpZMzczbDBWNnlyNDhKZldOSGZZYTJZUE5ZZjBmOGxTblItckxNNVI2S2p2dEpGM3JIRzFqZXBxa2xfUHc?oc=5" target="_blank">Small Molecule-Drug Conjugates Market | Global Market Analysis Report - 2035</a>  <font color="#6f6f6f">Future Market Insights</font>

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Small molecule– and peptide–drug conjugates addressing integrins: A story of targeted cancer treatment
Wiley Online Librarygeneral

Small molecule– and peptide–drug conjugates addressing integrins: A story of targeted cancer treatment

<a href="https://news.google.com/rss/articles/CBMiaEFVX3lxTFBhbWpiY1pnb2taY055WEJ4YkoyelpNRmNKQVNEenEwN01HQkE3Z3VxVGZmSzFuSzh6a2V1cDdsYVd6bXR6S0lxOUJrWFBkSklmTmV3akFPTFlQQkU3ZVhZTWRMMER4ekQt?oc=5" target="_blank">Small molecule– and peptide–drug conjugates addressing integrins: A story of targeted cancer treatment</a>  <font color="#6f6f6f">Wiley Online Library</font>

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Multimonth controlled small molecule release from biodegradable thin films
PNASgeneral

Multimonth controlled small molecule release from biodegradable thin films

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE5kTGxrcGNWOV9MbEVXYVF0ekMxMFN4RlpaZENSUTNrRzFrODk4cGV0TS1SVDZqSkZsZzJDTmZUZldhRTh1NUx6ajdCaGFkOXRTVmZMRmZfc2hubjk4?oc=5" target="_blank">Multimonth controlled small molecule release from biodegradable thin films</a>  <font color="#6f6f6f">PNAS</font>

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Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates
Naturegeneral

Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBVOHQ1OGRrbml0MXVTd0hhc2hTZXd6enREZGFLb0tMQjNOTmJnWFpyOVAwMzVvanRnOXdHS1hvV1J2T1ZkRmdyTVRQLWR0VklmTFNBbkVDZWxNdlZsUHN3?oc=5" target="_blank">Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates</a>  <font color="#6f6f6f">Nature</font>

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Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis
Science | AAASgeneral

Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis

<a href="https://news.google.com/rss/articles/CBMiYEFVX3lxTE12RExrZjlFWWs5X2lVQ1pQRGhMdzdxdV95ZWx0eHFkNUpCQWR6Q09ZNjl3SlNLU3FORGpNZjZ2b3hHcnY3NUZwT0RHRU1tZGpQRUNFNjFHT3p3YUQybzg4UQ?oc=5" target="_blank">Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis</a>  <font color="#6f6f6f">Science | AAAS</font>

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Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets
Natureworld

Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1IdmNadFdOc3pSaldRSmRrQThZWl9iMUZiM05WeHpJV05McnhCV1d4Tk9Yc0w4N3Z2UXVWVzVLOHp0eEFjTDBOQXNOWS1PMDNIVEdxZFZaYXVtUnY5eDFj?oc=5" target="_blank">Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets</a>  <font color="#6f6f6f">Nature</font>

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Highly specific intracellular ubiquitination of a small molecule
Naturegeneral

Highly specific intracellular ubiquitination of a small molecule

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBVRXBWcXAtMzhhZjBGQkJwY2M5bEtSUFNpNTVpR3ZVTWNIbDZHOTlZSWZacGlFdlc4cXlsbldlaGVzZk0zeV85X05tT1dKS01HRG1kcUlJeXphSzl4ZWJv?oc=5" target="_blank">Highly specific intracellular ubiquitination of a small molecule</a>  <font color="#6f6f6f">Nature</font>

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Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors
Naturegeneral

Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFAzbHNZZ0oyUzIwOC1zQzRvYk9vRVVtQUI5ZWtXbGxUS3YyMlVuLXp5ZkItbWN2cndUeTRmNDh1T0U4cEdQV3pHN1poWWZKa0Y4NU9xcHRTQ3B3cmliOUpr?oc=5" target="_blank">Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors</a>  <font color="#6f6f6f">Nature</font>

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Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor
Naturegeneral

Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9iLWlFUHdmV2k4TGdFSXdPcFRnNlZ3cWw5TkpkS3lxWVhzcWF3UWROV3hJdS1yN0E2c3R3ZDVtT2RuZEI5em1ISHVUT1ZLZkJuOVRROEo3WVhLaENyRk9v?oc=5" target="_blank">Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor</a>  <font color="#6f6f6f">Nature</font>

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Designing small molecules targeting a cryptic RNA binding site through base displacement
Naturegeneral

Designing small molecules targeting a cryptic RNA binding site through base displacement

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFA5Um5FX2dNMHc3d0owcXM4a0xuSHpVdTZRSV9jbHFqNm9xOGtLWkRIelZPb3F6aER3YjhqM3NKNjNobkZhWmV2dUJxSEsxTVpWSVVrblJkY29pNXQzTUI4?oc=5" target="_blank">Designing small molecules targeting a cryptic RNA binding site through base displacement</a>  <font color="#6f6f6f">Nature</font>

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Tumor-selective delivery of the PARP inhibitor Rucaparib via small molecule drug conjugates to improve combination therapy with 177Lu-PSMA RLT
Journal of Nuclear Medicinegeneral

Tumor-selective delivery of the PARP inhibitor Rucaparib via small molecule drug conjugates to improve combination therapy with 177Lu-PSMA RLT

<a href="https://news.google.com/rss/articles/CBMiakFVX3lxTE9NNmtjSkpfUkx4MkFtMFZqQ01MSG9WYWt4U0VrbkdrU2pEbTlVUXA0Y1BPQWRBTzlXd3lMWUl6NzJ4cXBwd2FlT1pLZ3NRZVNOZlVOR0YwYkstbXlRblZldHhKYnE2TTEzTHc?oc=5" target="_blank">Tumor-selective delivery of the PARP inhibitor Rucaparib via small molecule drug conjugates to improve combination therapy with 177Lu-PSMA RLT</a>  <font color="#6f6f6f">Journal of Nuclear Medicine</font>

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A Dimeric FAP-Targeting Small-Molecule Radioconjugate with High and Prolonged Tumor Uptake
Journal of Nuclear Medicinegeneral

A Dimeric FAP-Targeting Small-Molecule Radioconjugate with High and Prolonged Tumor Uptake

<a href="https://news.google.com/rss/articles/CBMiWkFVX3lxTFBRdXcxcFFKa21VQlNmaHhrZ29fajZoTXNwQi12ZnhqM1lBd1YyZndMWnRqUnd6dnEyUTJWR1RIX1JWY0NkTWZDOEstcTQ4RU5tcFFjN0Jfejd2Zw?oc=5" target="_blank">A Dimeric FAP-Targeting Small-Molecule Radioconjugate with High and Prolonged Tumor Uptake</a>  <font color="#6f6f6f">Journal of Nuclear Medicine</font>

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Targeting RNA structures with small molecules
Naturegeneral

Targeting RNA structures with small molecules

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5TY05SU2ZvRi1mdlpoZHU3S0Nabmc2NUtnRFlPUWtQLVVrcUwxLXVrNXNGSWdPcG1WR2ZSM2VleVdNdUl0S2t0NjA0Q0FYcXFGc3ZjcXh1SnpHQWh5emdJ?oc=5" target="_blank">Targeting RNA structures with small molecules</a>  <font color="#6f6f6f">Nature</font>

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Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer
Frontiersgeneral

Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer

<a href="https://news.google.com/rss/articles/CBMijgFBVV95cUxNVm9mUjdOX09WZUZLN0Zub2swSWI0am8tMGRBdUJRZUV5S3BzZllua1I5VDlMN3JtS0N0WTJlS1V0dFRRV1NMSzcyQmZ0T3liZ2kwUVBfaDQ1WFN1cFlnbTN4bzRUZmlPRDlxOU94NGNCS21Ud2h6T1JIMEV5blA4OGJtZjFVSmR4Z0JnV1hR?oc=5" target="_blank">Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer</a>  <font color="#6f6f6f">Frontiers</font>

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Molecular design and synthesis of self-assembling camptothecin drug amphiphiles
Naturegeneral

Molecular design and synthesis of self-assembling camptothecin drug amphiphiles

<a href="https://news.google.com/rss/articles/CBMiVEFVX3lxTE9UOFBFRlllZFN4dzBhaG1NWmRfU01VMlowbEJHNjhqbnNjTERiemd5TmZxeTVIN2dsbVNha25mbTg2aEF5OVg3WXdWR1ZoX1hzRG9hRg?oc=5" target="_blank">Molecular design and synthesis of self-assembling camptothecin drug amphiphiles</a>  <font color="#6f6f6f">Nature</font>

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IRA Drives Pfizer’s Decision to Focus on Biologics, Not Small Molecules
BioSpacegeneral

IRA Drives Pfizer’s Decision to Focus on Biologics, Not Small Molecules

<a href="https://news.google.com/rss/articles/CBMimwFBVV95cUxQTEoycldzbWFTeGNLZ1R2R05GNFdjUkZwbC1IRVZwSGVHY1h1ekxCWEZjbE1XQmFjaTlZOEt2TXlFR3ViWkMyaURaTDU5MjZoZDJlbmxRakJNQzY3eGk2dlNfU2hBOHF0MHR0NzZqM05pY3FnTm9UX2toUjJiY0g5TlBXTnhYMmdERGtOS2FkamNPUUloMUF1SnFFbw?oc=5" target="_blank">IRA Drives Pfizer’s Decision to Focus on Biologics, Not Small Molecules</a>  <font color="#6f6f6f">BioSpace</font>

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Bispecific small molecule–antibody conjugate targeting prostate cancer
PNASgeneral

Bispecific small molecule–antibody conjugate targeting prostate cancer

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTFBJcmhFUFpFZjhZVm5JRENob0NOZDhDSXFGbEY0bmxuaDU1dE1qWXJzYTdlbWdoMnZaZnNMWnZTd2RvSGlkRDhRazd2a0hNOXZfU0t5SDJQSkF3VVk0?oc=5" target="_blank">Bispecific small molecule–antibody conjugate targeting prostate cancer</a>  <font color="#6f6f6f">PNAS</font>

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A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors
Wiley Online Librarygeneral

A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

<a href="https://news.google.com/rss/articles/CBMib0FVX3lxTE9WTzlCYjZSMUotMWNlaW9vLTJ3YTEyYm1SazJtVVVRdEdzUkNGYjFIenp3dlZmcEVBMHdwM0pYZFh5SUxaeTRRb0hnUWhIWGlZS01oXzIyOVJrRzJvamtWRThYWWJRcEUtWmlSUHA0QQ?oc=5" target="_blank">A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors</a>  <font color="#6f6f6f">Wiley Online Library</font>

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A novel class of drug candidates for neurodegenerative diseases
Drug Target Reviewgeneral

A novel class of drug candidates for neurodegenerative diseases

<a href="https://news.google.com/rss/articles/CBMisAFBVV95cUxNR29TdmNvVEdsdWwtSDluZmhBR291YnhVZi11bHU1WWhqUzJNbGpqY3k3NExVQmVza01kZFU4bXYwMFlDb0dMeklocTAxVVNvZTBwenVMYV94ZTU5dVB4RUI4a0t4TnFhaW8yZDBlMlBfQTh3bXRuS1JCbEVyZFBaTVVnVVlQd2VWT1hyZUhjdVJ2UTdVNFRnbi15TUVLX0locEg2cG9jVnFna0hxNTREXw?oc=5" target="_blank">A novel class of drug candidates for neurodegenerative diseases</a>  <font color="#6f6f6f">Drug Target Review</font>

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Effects of microtubule-inhibiting small molecule and antibody-drug conjugate treatment on differentially-sized A431 squamous carcinoma spheroids
Naturegeneral

Effects of microtubule-inhibiting small molecule and antibody-drug conjugate treatment on differentially-sized A431 squamous carcinoma spheroids

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBfdUdVQTJXUl93YkxuYjNUZ241MEV6S0VjUklzU1h6MkJPemt5UUFzWDlzdkh1WDhoaGdSdEk2RzZzZUlMOHFiY2ZRcnAxZjYtbWcxX1FpclVaVUVGZnFB?oc=5" target="_blank">Effects of microtubule-inhibiting small molecule and antibody-drug conjugate treatment on differentially-sized A431 squamous carcinoma spheroids</a>  <font color="#6f6f6f">Nature</font>

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"Small Molecule Conjugates" — Live Google News Trends & Headlines