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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Protein-structure-guided" (30 stories)

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Structure and evolution-guided design of minimal RNA-guided nucleases
Lead StoryScience | AAASgeneral
Jul 16

Structure and evolution-guided design of minimal RNA-guided nucleases

<a href="https://news.google.com/rss/articles/CBMiYEFVX3lxTFBmTEV3eGRNcnlsME1yN0pwSGdaS3V1LVB4Mm1lQjhqT0dQOGVnMVQ2NnlJR1RKTThlWGIyNW45bDN6MHZiZ0tRSk9GbHAtbWhkaWlSaDk0TmN1YURTUjE1bA?oc=5" target="_blank">Structure and evolution-guided design of minimal RNA-guided nucleases</a>  <font color="#6f6f6f">Science | AAAS</font>

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Search Results for "Protein-structure-guided"

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29 stories displayed
Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles
Naturegeneral

Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5QMnNzR1dyMmtEVS1BcElwWEh4dVBxbHpCWjNKQUxyVmF1dFh0TW1ob2pZb05NazAwOUt6QUh0UFQ2NmFXVW13VHctNEl4MkNrTXhTbTRrQk5CMXZNUGRN?oc=5" target="_blank">Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles</a>  <font color="#6f6f6f">Nature</font>

Structure-guided analysis of divergent homologs unveils deep ancestry and arthropod specialization of the pacifastin family
Natureworld

Structure-guided analysis of divergent homologs unveils deep ancestry and arthropod specialization of the pacifastin family

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE96RWJ0OC1fLThlMlBKcDh6cm5wakU4aEVqWjBOVWkzTzhTWk1ZVWVJaDZOTlZEbGtVdTJlSFlvbEdkZTFIdm5TMEwzeEhRcnI0dnZRaERpTW5pT2EwSlNV?oc=5" target="_blank">Structure-guided analysis of divergent homologs unveils deep ancestry and arthropod specialization of the pacifastin family</a>  <font color="#6f6f6f">Nature</font>

Structure‐guided engineering of protein stability through core hydrophobicity - Ravichandran - 2025 - Protein Science
Wiley Online Libraryscience

Structure‐guided engineering of protein stability through core hydrophobicity - Ravichandran - 2025 - Protein Science

<a href="https://news.google.com/rss/articles/CBMiakFVX3lxTFBhTkdudEctbHNXamRXNVEycGxzUzhWcTJZZlBPX2hHc1oxQUdqTW1nRm5YdHN0dTlKZHI5bkNkZ1JzSHFDWTktN2NqUVdycUJWMF9zVy05azkwODl2WG5iN1hEbm82SGF2bUE?oc=5" target="_blank">Structure‐guided engineering of protein stability through core hydrophobicity - Ravichandran - 2025 - Protein Science</a>  <font color="#6f6f6f">Wiley Online Library</font>

Structure-guided PCSK9 vaccine shows preclinical promise
EurekAlert! Science News Releasesgeneral

Structure-guided PCSK9 vaccine shows preclinical promise

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE9IN2VQdmoxeFYxN2VjX3VyeTlkQ0tURzI1SnVlbFpZVE9aOFF0aXdzOXRIcjFVTzJTSFpFaFR5VVNmMVNKa3ZvWThIX245UTRzYXBBTHJvMElEU054?oc=5" target="_blank">Structure-guided PCSK9 vaccine shows preclinical promise</a>  <font color="#6f6f6f">EurekAlert! Science News Releases</font>

Structure-guided identification of small molecules potentially able to modulate GDF15 activity
Naturegeneral

Structure-guided identification of small molecules potentially able to modulate GDF15 activity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE40MWo1dFJTa041RGFISERtX3NDRHhMT09TTnFWVFZsVm1aMFh6cElRX3N4N0dZMHdjNlRNS0xVbmF5aGRNVE0zaWVrSzNIZ3ZobmZ1Uk1qM21RcVJDbGQ4?oc=5" target="_blank">Structure-guided identification of small molecules potentially able to modulate GDF15 activity</a>  <font color="#6f6f6f">Nature</font>

Unsupervised evolution of protein and antibody complexes with a structure-informed language model
Science | AAASworld

Unsupervised evolution of protein and antibody complexes with a structure-informed language model

<a href="https://news.google.com/rss/articles/CBMiYEFVX3lxTFBsZWxWQzB1QkRYMXRPaTZHTDM0eDdhd2VJV3FtcnFyVUVXNkxOMnBucXJkcHd6eFNySHBGcFFNdUYzSUtTbm9zbkVsM3dscWxfdEhybDRIenZzT28zX0lfSw?oc=5" target="_blank">Unsupervised evolution of protein and antibody complexes with a structure-informed language model</a>  <font color="#6f6f6f">Science | AAAS</font>

Structure‐guided insights into the biology of fungal effectors
Wiley & Sonsworld

Structure‐guided insights into the biology of fungal effectors

<a href="https://news.google.com/rss/articles/CBMiaEFVX3lxTFBsNGhSeVJBa1EyR0NwYVNvclU0cGJOQW42UUg5TVVfS1lMU210cERCT0x0bmRITWJXUmFLeXpsM0JMLWxIY0VxRlpkY1lSMXpzdzN1NmhQeVFTT1E4N25TWC1qR1dKUUxi?oc=5" target="_blank">Structure‐guided insights into the biology of fungal effectors</a>  <font color="#6f6f6f">Wiley & Sons</font>

Structure-guided reprogramming of DELLA turnover for a sustainable Green Revolution in rice
Naturetech

Structure-guided reprogramming of DELLA turnover for a sustainable Green Revolution in rice

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9tRFpXcnNMM3dxTlV3VmhDQWt4VWgwUVpQeTFhakJTb25uNnl3MHc0U0Njc0lTYTRUOVdiR2RiN25GYmc2U0NYX1d0Q2xjcHI3alhnVVV4ZHpvQWRrQ3Rj?oc=5" target="_blank">Structure-guided reprogramming of DELLA turnover for a sustainable Green Revolution in rice</a>  <font color="#6f6f6f">Nature</font>

Cross-protective human antibodies against the Mpox virus discovered through structure-guided screening
Naturetech

Cross-protective human antibodies against the Mpox virus discovered through structure-guided screening

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1xTTVaN1BTUkxabGN0Q2Z4SEh2dXg3Nzkzc3ZxV3R4LUpGdzY2RkN1Y3JjQm1zam8zMGtxYUFnN0FqVmJVcGRwM3FqS3FHa01Qb2F3QzV6UFRZRzVpNUc4?oc=5" target="_blank">Cross-protective human antibodies against the Mpox virus discovered through structure-guided screening</a>  <font color="#6f6f6f">Nature</font>

Altering the carbohydrate-binding specificity of the legume lectin FRIL through structure-guided engineering
Naturegeneral

Altering the carbohydrate-binding specificity of the legume lectin FRIL through structure-guided engineering

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9Ra0owNFRuYmJFZzh0c0dldUJQSHVZeHRZSVFxZFduTWdwb0dBY1ZJZjFnQ1JXUjhIUDFYUm5uWTFjdmlsa2hkc0tPUThpRWdpaUtjZWxkNEJScWdpNVBV?oc=5" target="_blank">Altering the carbohydrate-binding specificity of the legume lectin FRIL through structure-guided engineering</a>  <font color="#6f6f6f">Nature</font>

Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1
Naturegeneral

Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBYRFhUdnNXNHJycTZQZ2tSTGpYeVQxYV9HRjhSaEFNZVZoQ0xNYUhwS3lrZnlTWFdtaGJZWmRLYXRTbndibWR0cDFCWW5jVkFPTmtoN1l0QlIzdGFkcTVB?oc=5" target="_blank">Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1</a>  <font color="#6f6f6f">Nature</font>

Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface
Natureworld

Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9UZFFGS2pWLVh2NTZrOEVURVBJZWRrWDVZdG03ZGU1SzB6V0lrbC1vcFdXc0RCbUlBRjJvV2Ytb09XTmFhbEVFdlA4dGg3UDlfZWR3YzItbDN1Y3hEdTZ3?oc=5" target="_blank">Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface</a>  <font color="#6f6f6f">Nature</font>

Protein-structure-guided discovery of functional mutations across 19 cancer types
Natureworld

Protein-structure-guided discovery of functional mutations across 19 cancer types

<a href="https://news.google.com/rss/articles/CBMiUEFVX3lxTE9rVjIzQ3FvYWtCMmY1UlFuamxmQzJ1QTEzN1draEZISTNQSHlfZHhzbnhDeHdBdExjN3JKX3ZmUU1JS0MxZ3BLbnhIZzlXSjls?oc=5" target="_blank">Protein-structure-guided discovery of functional mutations across 19 cancer types</a>  <font color="#6f6f6f">Nature</font>

Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1
Naturegeneral

Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBYTFA2WG9zWFNYTW80VlRPTVEyQk12Ql8zbnUxeFBYYnk4c2ZIdVV2NzNXVC1Ea0NieVJodTVqZzRFS1FoMjY5cTUtZ1A4MWd5OTZ5aFY2NjJwT1ljMG53?oc=5" target="_blank">Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1</a>  <font color="#6f6f6f">Nature</font>

Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context
Naturegeneral

Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1FNDdRNEtqNi1XY2h5VEVOMkZGZDI0N0pUZjBSckhkNE5nUzZ3bHdLal9VenN1ZGpfWVZySEJ4QkhYcHlrNzJrUEFPeml0Y1lLUmpzMkNvRnVzRmgxeWo0?oc=5" target="_blank">Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context</a>  <font color="#6f6f6f">Nature</font>

Structure-guided discovery of anti-CRISPR and anti-phage defense proteins
Naturegeneral

Structure-guided discovery of anti-CRISPR and anti-phage defense proteins

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1hc3lWVTVhTnpSM1UwVVg0bUdKdEJxbTJjQXo2VjdXNDU5R3gwSkhwZW9nT083LXZ4d0RLRGw4MGp2LWZNVkdXUWhzblFjM2hqN19HUGlXV24wUlhacmJ3?oc=5" target="_blank">Structure-guided discovery of anti-CRISPR and anti-phage defense proteins</a>  <font color="#6f6f6f">Nature</font>

Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
Naturegeneral

Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFA0REF0aWU2SHZWUy0tTFVqc1JoVTdfOEJTR2tvTmM3QVdtWkItVzVRb3o5MFNacksxVFJHNUdtSDZHcWpnMlpVSEJkQk14TnRIVUxFYXNjcWNCWEtwUGw0?oc=5" target="_blank">Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites</a>  <font color="#6f6f6f">Nature</font>

Improved protein structure refinement guided by deep learning based accuracy estimation
Naturegeneral

Improved protein structure refinement guided by deep learning based accuracy estimation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ZYmQ1UjBldnNMajdvQTRpOWJFdWt0WE1TbFFGVWdZdlRHdjYzeV9sQk5wVmJiNFR5anZVOGMwUXNCUmtUUWhWNjNua3BxcWstaDlQZWF6TFJ1ZnhlTFVR?oc=5" target="_blank">Improved protein structure refinement guided by deep learning based accuracy estimation</a>  <font color="#6f6f6f">Nature</font>

Blocker-SELEX: a structure-guided strategy for developing inhibitory aptamers disrupting undruggable transcription factor interactions
Natureworld

Blocker-SELEX: a structure-guided strategy for developing inhibitory aptamers disrupting undruggable transcription factor interactions

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9sdmMtOXhqWmxPNjByXzNKWlgySTJhZVk3TTJYeWctYmFJNW4tYnBhbEVEcFBNWWQwVzA5WVdiblZ5MG1vb1JSbFNUZTQ1bW0xN0xCa1lvQlZvY1NFVXdF?oc=5" target="_blank">Blocker-SELEX: a structure-guided strategy for developing inhibitory aptamers disrupting undruggable transcription factor interactions</a>  <font color="#6f6f6f">Nature</font>

Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence
Naturegeneral

Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE00R1pTdDZKanJLbnVXbGdDeWo2VHZ0ZnE5c096SkhmRThFT210UWxud3NVaGdDRlhPai1Nc0U3MWQ2b3ZUQVlROUMyTUthZVVRbWtZMW5qb3NtdkRERGo0?oc=5" target="_blank">Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence</a>  <font color="#6f6f6f">Nature</font>

Structure guided functional analysis of the S. cerevisiae Mre11 complex
Natureworld

Structure guided functional analysis of the S. cerevisiae Mre11 complex

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5XVXRpcUt6a1ZaVE52SVZ3UEV3eFA1X3Y4M2xUZ2s2U3FUa1M5N091UG93MDA2OGZYdEhUZUZxZ29hR3JXaDF1S1hoU1JETHJ2T3VHNEVIOVBvS2tsV2h3?oc=5" target="_blank">Structure guided functional analysis of the S. cerevisiae Mre11 complex</a>  <font color="#6f6f6f">Nature</font>

Structure-guided affinity maturation of a novel human antibody targeting the SARS-CoV-2 nucleocapsid protein
Naturegeneral

Structure-guided affinity maturation of a novel human antibody targeting the SARS-CoV-2 nucleocapsid protein

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9Vd0JwR0tOcHJjcExKaDc5VTgtNVN4ZGZZLXRXU2VpMWJrY3pHaFNORi03bDVaczRCek00Qy1mSjl3bnR2XzVvclVMNERjdW90ZHo0cmZIOFBfWkxQM1hB?oc=5" target="_blank">Structure-guided affinity maturation of a novel human antibody targeting the SARS-CoV-2 nucleocapsid protein</a>  <font color="#6f6f6f">Nature</font>

DPFunc: accurately predicting protein function via deep learning with domain-guided structure information
Naturetech

DPFunc: accurately predicting protein function via deep learning with domain-guided structure information

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1YYmsxOUNwZHhRRVNKYkRvTkNlal9pQmJHMVdrU3JNQl8wUk5rNF9GNXp1TzVBNWFxY2ZpVTF3LThWX0JjU1puQzZhVUtoLS13THZlSzJNZXNKWFhtbXFV?oc=5" target="_blank">DPFunc: accurately predicting protein function via deep learning with domain-guided structure information</a>  <font color="#6f6f6f">Nature</font>

Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases
Science | AAASgeneral

Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases

<a href="https://news.google.com/rss/articles/CBMiYEFVX3lxTE9RWlQycFVaMFZUVzJFTU5QUTB2eXIwczdUSU5laGxITHJ5bkZfUDFWQ2kyeVh6dC1kSF9OSURIZkZPSW5uNG12c1VHbG5WYWJTZ050M1Zld3ZDMDFrRkNweg?oc=5" target="_blank">Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases</a>  <font color="#6f6f6f">Science | AAAS</font>

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution
Naturegeneral

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1ERF9GYnZPLVBJYjN1ejB0VGFpQjF6ZEhldlhGT0sxQTJaWGVpbEE5ZkVoR2RERjliYjNsdHlWMkQzdm1HNXZVclpuT1cyMldnZ182eHFWZ1YweVhwaEU0?oc=5" target="_blank">Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution</a>  <font color="#6f6f6f">Nature</font>

Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma
Natureworld

Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1KRmc0MmR1bWZlQW5NeFBDdldBSFNNX2dub2UtbUxBWmg5NEV0azNkLVM4WVJxcGJwUjZMTnAwYnV3M3ZpdV9CaWZtVlh3djZRTnVwcE5zSzhVSnctR29Z?oc=5" target="_blank">Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma</a>  <font color="#6f6f6f">Nature</font>

Structure-guided screening identified bioactive phytoconstituents Hernandonine and Anolobine as potential inhibitors of dual specificity protein kinase CLK1
Naturegeneral

Structure-guided screening identified bioactive phytoconstituents Hernandonine and Anolobine as potential inhibitors of dual specificity protein kinase CLK1

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE4tZWlLOENHbVBtaUgwS285dTYxeFAxcGROcDZpUGQwOXJEckFnZmxzSnFJUGpWVU1oSXQwQVJibUt2VHZIalkyTEY2NTlyMWVPQkR5NzBKZmVaMnZoaEpr?oc=5" target="_blank">Structure-guided screening identified bioactive phytoconstituents Hernandonine and Anolobine as potential inhibitors of dual specificity protein kinase CLK1</a>  <font color="#6f6f6f">Nature</font>

Protein structures guide the design of a much-needed tool for neuroscience
Naturescience

Protein structures guide the design of a much-needed tool for neuroscience

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBxNTYxc013Y0ZGS1hKNEdlTDZRMmNCekZCSnFseldEeExnR1g0eURSR0w1SGpSX09iYmw0a0lZeU5PeUVkY2IzdjhNSzRzTWY0d3hvUUZURi1CZDQxb0xR?oc=5" target="_blank">Protein structures guide the design of a much-needed tool for neuroscience</a>  <font color="#6f6f6f">Nature</font>

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%
Naturegeneral

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%

<a href="https://news.google.com/rss/articles/CBMiVEFVX3lxTE5jTzJSaUZIWVB4c1RhLU9QSk1GaGlvcVNMUGRMQUw1QTlRaFdROGxhY0xOZVE2TkJIdkpyYmRCbDQ3UHNuSzNKcXFVMEJ1Y2ZtVTdJUg?oc=5" target="_blank">Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%</a>  <font color="#6f6f6f">Nature</font>

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