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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "PrimPol-dependent single-" (25 stories)

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PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
Lead StoryNaturegeneral
Nov 17, 2020

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFB0T1V3N1RQeDcwSHVJYkYxQWlfRzRVSEgxWjJ5aE1iaTFaTzZERTh0Rl90YTEtUGZWd3UycHlnOHRpX0U4QlpaOFQ1X0NzbE11SDZ1VVJBNmxPZTJna1RF?oc=5" target="_blank">PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "PrimPol-dependent single-"

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24 stories displayed
SLFN11 counteracts the RFWD3-PRIMPOL DNA damage tolerance axis to restrain gapped DNA synthesis in response to replication stress
Naturetech

SLFN11 counteracts the RFWD3-PRIMPOL DNA damage tolerance axis to restrain gapped DNA synthesis in response to replication stress

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE45MC1KNnVQdHQ3VzdoQlEwNVpaUEpaQlBvcTlBeW9RT2VmQjROenlhdjZLNElFb3VyRXN3VDJHanhBMHdkcW9hQ21UQ09ieDhjMzd5MGRXeUpWM2JIYlBZ?oc=5" target="_blank">SLFN11 counteracts the RFWD3-PRIMPOL DNA damage tolerance axis to restrain gapped DNA synthesis in response to replication stress</a>  <font color="#6f6f6f">Nature</font>

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The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells
Naturegeneral

The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE4xMDNLakdLc25IMW1STDF6angxd2hlUUhkTjdjdHpyS05CeDR6VTdES1dNWkozbnZiTGJ0N0haSmxuWU81NHNlR3M0NkdpWXh1Z08zTUl5U1Y2RzJZRTRZ?oc=5" target="_blank">The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells</a>  <font color="#6f6f6f">Nature</font>

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New study could help predict which individuals are more susceptible to cancer-causing agents
Medical Xpressgeneral

New study could help predict which individuals are more susceptible to cancer-causing agents

<a href="https://news.google.com/rss/articles/CBMikwFBVV95cUxPT3NQcFl5RnRrQ01SUkhrWlNMRkVPc3p1VXZycVYwenh3Wm1XWFJWdzFFdnROWW1fQmNvLUdGNk9vSkFSNXlJa2ZiNFRFREY4T2hqczlyTHJvdE40WTRMRUVDRkhEcTRqdHRGUnlDUnVqbE9FVVhST3dvMnE3RndscUxiRlN1NjhtRWNaWDEyTjRzWG8?oc=5" target="_blank">New study could help predict which individuals are more susceptible to cancer-causing agents</a>  <font color="#6f6f6f">Medical Xpress</font>

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RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress
Naturegeneral

RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1VWnlEckYyUFpBZEtxOTNXOS1UNXpra2RJZE9wZ2wxZ25DdDJxUUNKZEFXSUNKOU1rWUtleWhfQzVyYy1GVlQzNFhuN3N4TzN2VDE3bGJaMjFhcUdxbjNB?oc=5" target="_blank">RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress</a>  <font color="#6f6f6f">Nature</font>

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The need for speed: drivers and consequences of accelerated replication forks
Naturegeneral

The need for speed: drivers and consequences of accelerated replication forks

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBrLXBmMlV5c2xKeVhMSFNxMnRtSkJleDB6OXVnMmRJeHRtVWgwcUNId1RLc09MTDJNbW56REZaQWwyTG9aZENKaUFuNGlvN1Q2RVYzS2pTTGs0cm5pVjNn?oc=5" target="_blank">The need for speed: drivers and consequences of accelerated replication forks</a>  <font color="#6f6f6f">Nature</font>

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BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage
Naturegeneral

BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE13Wkd2UFJlT2xBVmhWd3IyZldXaG5HTE1PeGFMYmlzNzh0cmF1a2JxRDBYcjZNR2VDSllidUFGT0lEaVpTMElFWmFSa25RZVlMdUNTYjRIUVVWa2RJaFhv?oc=5" target="_blank">BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage</a>  <font color="#6f6f6f">Nature</font>

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An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress
Naturegeneral

An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBCeHY0TzQ4bnBiV25ULS1IdzduS1NtUVRIX1FfcFF3emNTdzNwMy1Zd2xBeHNaVm1hSlN2ZmtoVHRFU3U1S1pCeG1hNGZpdGNOdWpmeFZSQU1HaURXTFJz?oc=5" target="_blank">An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress</a>  <font color="#6f6f6f">Nature</font>

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Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity
Naturegeneral

Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE43dlVFcEN0b3ByTWMtdGxTLUFrWDdwOXhuRFlEb0ZiRDhvS3BwMTd4cUdlOEEwbERPZHlILU5FSmNCNERqaVRHanAyUmllNUgyUWs2X2xxZzh0WlFncU5B?oc=5" target="_blank">Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity</a>  <font color="#6f6f6f">Nature</font>

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DNA polymerase α-primase facilitates PARP inhibitor-induced fork acceleration and protects BRCA1-deficient cells against ssDNA gaps
Naturetech

DNA polymerase α-primase facilitates PARP inhibitor-induced fork acceleration and protects BRCA1-deficient cells against ssDNA gaps

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5fUTNuNTUxdkd4bHQ1UnJqUWhLbVVMQk14Rzd3N3dzcFpoZjFnYWgxd0xUVXJ4dndMOGNNejF1RGo4Vm5fMWtscXJ1Z05hZXN1dUN4dFA4eXZzaWs0V3RR?oc=5" target="_blank">DNA polymerase α-primase facilitates PARP inhibitor-induced fork acceleration and protects BRCA1-deficient cells against ssDNA gaps</a>  <font color="#6f6f6f">Nature</font>

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Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases
Naturegeneral

Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBMZ05FZDBuT29vZGs5WjgzSld2VXVNSGxxYVJwRkdJTjl5ck95QVlxcmd2LXpQS1pOd2ltb1gySWdWNUR4eGMyUlJ1V2d2ajRnX1VvY3FDbVFnUkpicnpN?oc=5" target="_blank">Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases</a>  <font color="#6f6f6f">Nature</font>

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Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure
Naturegeneral

Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBlblk5N0JWbXZRUVVtNGhvSTY3QlVCaTVYT1RjbTUyTDlMSDZONjZDVks1ZklHZ291RXdfZG5MZUEzMWl5UF9Ca0xITW9NZFp5Tm5ZcE5zeVBHTms1Tktr?oc=5" target="_blank">Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure</a>  <font color="#6f6f6f">Nature</font>

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Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling
Naturegeneral

Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE52SjRrcXh1bHo2cnpFSm0zTnNJN1ZlUmNlNVN0Tk44T3owTVpzUzhsdFp3STBKSlFDY2dhRzljanBUb0xseDBBdVRnTEFwZ211TE5ONXNqcTR2UXRjS2Uw?oc=5" target="_blank">Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling</a>  <font color="#6f6f6f">Nature</font>

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Targeting common denominators of DNA damage tolerance mechanisms as therapeutic strategy to cope with dynamic phenotypic changes in triple-negative breast cancer cells
Naturegeneral

Targeting common denominators of DNA damage tolerance mechanisms as therapeutic strategy to cope with dynamic phenotypic changes in triple-negative breast cancer cells

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1MMHRuaTNuV0tBcXVTc1FXbGVqUVZ6VUJubXFvdVNVWTU3cVlTU2pSNlhGcER0MnlqdmVtR01FREh1ODMzZ2dHMC1Mbi0xQjUwNlQ1WWo2bVZ6a1BTTm1V?oc=5" target="_blank">Targeting common denominators of DNA damage tolerance mechanisms as therapeutic strategy to cope with dynamic phenotypic changes in triple-negative breast cancer cells</a>  <font color="#6f6f6f">Nature</font>

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The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells
Naturetech

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBnZWZjM1cyRnIweEZON1RLUWcxYVR6Q0gxMVZfT1BtWXYyd3lPazZySFpGd2NXZExGNlVtVUNHdV9WbmNDTV9tcGV4VTUyUDQ0SkgtMEtEMzBieVpteFVN?oc=5" target="_blank">The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells</a>  <font color="#6f6f6f">Nature</font>

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FET proteins and PARylation-dependent condensates promote replication fork reversal and genome stability
Naturegeneral

FET proteins and PARylation-dependent condensates promote replication fork reversal and genome stability

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5LUE9oUkpHX25zSXk0MDNYYlpxOV9FVGpwM2FPMXpSUEN3WVlhOXhCeFJfSXRxZ01qZlhMN1ZaNHVoR2dKVHpJOHhyUTA3UnlaVkRkTzVjN3VTVm9GSERr?oc=5" target="_blank">FET proteins and PARylation-dependent condensates promote replication fork reversal and genome stability</a>  <font color="#6f6f6f">Nature</font>

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PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesis
Naturetech

PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1Qd2Nxc1l1SzN1S3RrV0h3YmFMWnpHNWViMnJVMW42S1ZsUVI5NjdsUGU0c0RBZFZpdGFrcHFfQmZfY2llTjBzZjJIZjVZWVlPeDd6b0lrVmhiV3VQU1ZB?oc=5" target="_blank">PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesis</a>  <font color="#6f6f6f">Nature</font>

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Excessive reactive oxygen species induce transcription-dependent replication stress
Naturegeneral

Excessive reactive oxygen species induce transcription-dependent replication stress

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE15bEhTbklKQ0xBaDhhSmxYMWoxVU8tTjJPTjNsN2pYZlE1eUxxY24zX1k2NF9DY1pQVmkzc2hoT3B1OW5MV1RfSVJKSnR6bzhiUDF3VVZJbFZyVEdIZzBr?oc=5" target="_blank">Excessive reactive oxygen species induce transcription-dependent replication stress</a>  <font color="#6f6f6f">Nature</font>

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TRF1 relies on fork reversal to prevent fragility at human telomeres
Naturegeneral

TRF1 relies on fork reversal to prevent fragility at human telomeres

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1KdzB4US1zRWlCM2xQdWFwd3duMUdISU9LdlF3ZDNrNkd4RUVVSXRiNjREdS11ZnJBNDZEbmdtb3lHbG95QjNTZWNkY2kzSXNLU0hOMTNzMHk3dzFSb3NN?oc=5" target="_blank">TRF1 relies on fork reversal to prevent fragility at human telomeres</a>  <font color="#6f6f6f">Nature</font>

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Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient
Natureworld

Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE03dnctR0RVMElmRDdkOHdDTVlBZXlmRFRTYzZib012cmVpZ0JFcnpsbzh4Z3NndnJocThSZWhnbmJsSDNYLW5DTVhfOE82MGx5RGFybXNVZGFlU2VHN080?oc=5" target="_blank">Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient</a>  <font color="#6f6f6f">Nature</font>

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Replication gap suppression depends on the double-strand DNA binding activity of BRCA2
Naturegeneral

Replication gap suppression depends on the double-strand DNA binding activity of BRCA2

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFB0bU9DczhBRUJkaFNnMVNVcmoxbWRfbWtOVHcwdEdfZTBELTBhN3I2WWdWNHAzTEprZ1RkYnZDTkdtQlZVTXR1dG5NNXpIV3ViNW1qWTZ6QUlBeXlwN1FV?oc=5" target="_blank">Replication gap suppression depends on the double-strand DNA binding activity of BRCA2</a>  <font color="#6f6f6f">Nature</font>

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Mechanisms for Maintaining Eukaryotic Replisome Progression in the Presence of DNA Damage
Frontierstech

Mechanisms for Maintaining Eukaryotic Replisome Progression in the Presence of DNA Damage

<a href="https://news.google.com/rss/articles/CBMinwFBVV95cUxQVnhYZXotREVxQWhuUGd2V29WbGdHOUNXYUxDTDBacTRRSkp3cGNKVjdBSjdzb0oyT1hRUFk3Qlc4SHhBLXNBZ3ZtNXd2M0pYeVBWNm9lRmNHajJtQ1JuNVNPTG9iNEhpRkpGdDNYRWhOREpMYktCbkYwTHlGNUlVbWFocXZqNEFPRWxKdVUxU05RNXNieG9qcXhnM290eFU?oc=5" target="_blank">Mechanisms for Maintaining Eukaryotic Replisome Progression in the Presence of DNA Damage</a>  <font color="#6f6f6f">Frontiers</font>

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PrimPol is required for replication reinitiation after mtDNA damage
PNASgeneral

PrimPol is required for replication reinitiation after mtDNA damage

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE9PZjJZbk15OXlsS3RQMkE4S0ludDNfQkt2UmxsMElxTzNlYXpuYWhCOXFfbkV5bmZ1NU04d1ZVVnpzdk5sMHRGc3YtVUFFd3d1bEd6VGszeTc5NFFD?oc=5" target="_blank">PrimPol is required for replication reinitiation after mtDNA damage</a>  <font color="#6f6f6f">PNAS</font>

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USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA
Naturegeneral

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9saXhxd1E2ME1rVnAxdVU0OXFLQ193c2NJRGVXVDBNT1JPMTRtd1dtcUxHbzZwdWh4NlQ3d0FNTGZ2Q09wdXRRaWViaXYtTlZaT3QtQ1BMQWhKSG9kM0ZN?oc=5" target="_blank">USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA</a>  <font color="#6f6f6f">Nature</font>

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Mutating for Good: DNA Damage Responses During Somatic Hypermutation
Frontiersgeneral

Mutating for Good: DNA Damage Responses During Somatic Hypermutation

<a href="https://news.google.com/rss/articles/CBMijwFBVV95cUxNVUhnaXQzcG5PU3o3ckdab1prakVnWFFreGRFZzdGSHppMzBNSVAyVXBkeHFfYXdJZWRTMGwwVDFVZmxxOU9UUlJ2VWVTT1lDTlpCYVFGYzFoSjJZbDZpdm5wUHhhNXk5eTk5UXVzRmVlWFhaOExyMTVqWExGbjlpdUc1WjZnQmUzSU5TSXQ4VQ?oc=5" target="_blank">Mutating for Good: DNA Damage Responses During Somatic Hypermutation</a>  <font color="#6f6f6f">Frontiers</font>

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