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<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1Oa0s4Ni1yZFRmR2h4MnUtNl9RakJVYW5scVF6VktlMkMtaFNlV25tWm9zSDZaLU9LdHFVZ1JYVTY5X251WWQzQjJLOFkxM2pZcVpTSUZOU29LYTdvbnh3?oc=5" target="_blank">Pre-splicing conformation and stepwise circularization of a group I intron in Azoarcus pre-tRNA</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
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<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTFA5SUlKcWZWLXFoYV8yZHdxRmE4NmdXWmpRdk1zUy1KYm1BNmNGeHhudmRWaWl1Q3QyYkxiMVVPMU0zWjA5aFJKaVZpajJwQ0xraHRScW5GbF9zUW5Z?oc=5" target="_blank">Controlled dynamic remodeling of the spliceosome active site enables the first step of splicing</a>&nbsp;&nbsp;<font color="#6f6f6f">PNAS</font>
<a href="https://news.google.com/rss/articles/CBMirAFBVV95cUxPOERTbEdlNk9tQXJ6MDBRR19VNklxanZHdHBZeEY2Q0RMenVkTUFTSHBjZklUbnRFaTFfZU9ZbHJPZ2tCcW5nQ1M2VkNUUWwxVzJmOHJkVy01NVp2VU1LU1V1eTRUOVlzQ2JSakFBTlNxc0NnSDJvdWppN0hUMXVLdS1JQW5DRVgyV3dvTkQ0UmR5anNrdlNqcW9MazRaRkd5cmR3b1JZZ0VVc2k2?oc=5" target="_blank">Unlocking the undruggable spliceosome: generative AI and structural dynamics in cancer therapy</a>&nbsp;&nbsp;<font color="#6f6f6f">Frontiers</font>
<a href="https://news.google.com/rss/articles/CBMia0FVX3lxTE9zTkxHaW1WMk1lcDRSb3RtTnExY3NHT2lSSjk0dzFGNWw1QkM4SVJtYUljVXhVQ2VhT18zZFVmeVZKdGZjZ2pnSXVZdTZvaTdoWXBSbVB6ZmM3ZWJqZWl3eVAwRnRjSkExTWlJ?oc=5" target="_blank">Mechanisms and regulation of spliceosome-mediated pre-mRNA splicing in Saccharomyces cerevisiae</a>&nbsp;&nbsp;<font color="#6f6f6f">Wiley Interdisciplinary Reviews</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9mODVhaGNVNy1tempOS1NoS3hjY3BkenNXeGNOTGh4Z2E5ODZpUnR6MWYyVW84TGtUNzF2RzY2OEdlUm85UUc0Y2FPWTBmNFEyUE9qNXVYcUpveDlHRGF3?oc=5" target="_blank">Recurrent Neurodevelopmentally Associated Variants of the Pre-mRNA Splicing Factor U2AF2 Alter RNA Binding Affinities and Interactions</a>&nbsp;&nbsp;<font color="#6f6f6f">National Institutes of Health (NIH) | (.gov)</font>
<a href="https://news.google.com/rss/articles/CBMiYEFVX3lxTE5LUTduNzR5dklON0hseUhyTjQ5OGZpVEdPaUNROXdqbzJxalFHdy1iR1VVUEtLRFNqZDV2SFN6cEhpdk1fU2tUV1FobV9GX0dvd3hrYmtRWmhVYU5TZmhoWQ?oc=5" target="_blank">Postcatalytic spliceosome structure reveals mechanism of 3′–splice site selection</a>&nbsp;&nbsp;<font color="#6f6f6f">Science | AAAS</font>
<a href="https://news.google.com/rss/articles/CBMiWEFVX3lxTE9fdWtYaWJ2ZGlSMmdaLVlBZkFiNzV5dXp1X081RWt4SVltekNRX09nQm52RG9xYVVmdWdka0pXYUNmTnJ0X09GbXNoSDkwek05MEdQaGhBbkU?oc=5" target="_blank">A Generalizable Strategy for Imaging pre-mRNA Levels in Living Subjects Using Spliceosome-Mediated RNA Trans-Splicing</a>&nbsp;&nbsp;<font color="#6f6f6f">Journal of Nuclear Medicine</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFAyZEs1dmpTczhGeEc5aHBTZDdmVld5dnBtVUNXUUhLLVN0MFZvazR1ZHZ4cWtqMjExRFpZYUhHenNmczVXMTVOYXZqeWhQeEpJdzFFZ2NobzhmcFlDZTBr?oc=5" target="_blank">Structural basis of catalytic activation in human splicing</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMirAFBVV95cUxNU3RkWGRucVVqbm93cVhtWlRBQjFjUG1EVWVJQk4yZ0dpd1JoeGRyUmdQVUY1VWhRQldaVXdiYnNOcnA4N1JvM3BhLUt3TVVJeEhrNC02ZWFMeVdiZFUxbl82cnhsXzFCWnN0OTk0RHJoaHVJSkE5Zi16LU80eHJ3TFJRSU00c0hsakNaandTMFlLdlgzZHFvZ01FeUVoUmFrT0hMQUh0VEVsSlg2?oc=5" target="_blank">G-patch proteins: important regulators of pre-mRNA splicing and ribosome biogenesis</a>&nbsp;&nbsp;<font color="#6f6f6f">Frontiers</font>
<a href="https://news.google.com/rss/articles/CBMickFVX3lxTE4xdUlQM2FxdUlvcVdQcHA3NUk1bVZqSE5Tc0tSN1BTSk51cEpYRndGbVBJbEgtSF9Sc3Bwdkd5VnQwc2pueWpWWHhZandtcjYtbFVYcWNCMDlWbWU3RWhsbzh5RkdCMVYyYV9ic1RXMzlpZw?oc=5" target="_blank">The spectrum of pre‐mRNA splicing in autism - Engal - 2024 - WIREs RNA</a>&nbsp;&nbsp;<font color="#6f6f6f">Wiley Interdisciplinary Reviews</font>
<a href="https://news.google.com/rss/articles/CBMiVkFVX3lxTE1iWHVFWHZHUV9zMnp5aHZjYjB0ZFlSSW1ua21kbTRCZ2x2LWtRNmg1MGZoSDNFaVdFa1NkX29pRzJkTG85bkJzWllqSHJrNEFncWNEMjF3?oc=5" target="_blank">Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9MY0duZ01yZ1lWZ0NRMWlZMUF4MFU5ZFFrLVpPU2ZhOUJzbGYxS3otTF9OMG1DVTd6Si1xTkhNbVVtLWRHYlJ3TVo0eG0yajdMaW1jYjB2Z01LUW13VGhv?oc=5" target="_blank">Molecular basis for the activation of human spliceosome</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiU0FVX3lxTE1DZDhiTHVoWVBTbXBWNXFwLUZycVloS0FJemM1RXAzelB0QnZNcURNWHBvUUgwdktIbkdlNnVwR0JEOUt3WG94UzhENFpVTUhGRmVB?oc=5" target="_blank">Conformational dynamics of single pre-mRNA molecules during in vitro splicing</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiUkFVX3lxTE1vSklIMk5YWGIwUjVzRlZ1YmZNMXlsRnBwcW1kaWxQZkU0ZGkyRmJKYkNRX21UOHVDX3dHSzdhUjJmUlF3UENXNktUeUQtSTA4Z0E?oc=5" target="_blank">Structure of the human activated spliceosome in three conformational states - Cell Research</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE01V0JaNHozVEgwNjNMWFlJLVdsenRVcFEwYkd3QzZzYlRuSWpjY05sYkpVWlNUUDFYU2ZXZ2dLaFVEUjRhbVV0cm1PR21RMU1mRnZ1b2tiOUYxbl9NNHc0?oc=5" target="_blank">GPATCH11 ortholog Sap34 regulates pre-mRNA splicing by interacting with early spliceosomal complexes in Schizosaccharomyces pombe</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5BamlfSVU4NWF0Z2tsc0JoWXhBY3EzTllKTTZDT2NjNVJtNGZjTWZjN251VklqTEhxaFdNRXdDQUd6Rkd5aFVQX24wQzRDbjdTSTdoZlZxS1VVU3BVRXdN?oc=5" target="_blank">Mechanism of alternative splicing of yeast HEH1 through competing 5’ splice sites</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1jWFVfNi1RMC0zNUFvOFpmRm02cVRNaThkSnptelQyaGpmN0N3bDNZSzAtWEQwaU9zMzYtcTlldDBUSUcyYWI3eDFuSnEzRklkSzBxTkhMdm85STRWOUdj?oc=5" target="_blank">Structural insights into intron catalysis and dynamics during splicing</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5DZ0lVSWZTTXU4REFmWmIxZXB5bENwa3RINS1zcjZjSmU2aW9pWUFhZk9uMnA0ZVE5VGZUeDh0VnV6Y3VyUVNLZ280SEZadVlPMFgzWERfMkF6U2JRNmdr?oc=5" target="_blank">Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5rUGtYT2drai1HblZMTjJOZ2pMRS1RZzZZWE1VdUU4Rmcwcm94cnNrbWhzZmN6NVFLNVdDcVNMSm5qZzE2dGV5M2tfZ3NCTHNWcXNraFNERjQ1RjgxeTNz?oc=5" target="_blank">Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBYSU1BVUZyam9KV2VnM245NjRxUjlRUFJxUDFqTm9aUEdzanZCdnI4eUtreGx2QXU5b2F3dm5tZE50R1RFc3VhZzdsWWg4WFFuTkZUQk1PeXVrRVZxZV84?oc=5" target="_blank">Targeting the conserved active site of splicing machines with specific and selective small molecule modulators</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE1LTm45enpFYUtkS3FodVRTWVJqdEQwajNNd2JNS2h5cXg0R1hZenltQnFNM3pJb3VlOEF0dVItdVhQNXNvNDVOcElLdkVzRy1qVHZOZEgtYWk1cmRM?oc=5" target="_blank">Prp8 impacts cryptic but not alternative splicing frequency</a>&nbsp;&nbsp;<font color="#6f6f6f">PNAS</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBDNm4zejBhNTEwLWxBbmhjUmhLWlJ5a2VMMDRqbDlEZVZINFZlZGdXOXlvMFdCQTU5dnlERjluYUVOZWo4Zlk2S0w3N04tbmExUlJnUmFpb1lFUHRwTkFB?oc=5" target="_blank">DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMidkFVX3lxTFB0NlpVTkpZcVRQV1lYdnhCYm0tMHhkTmt2N1NmVjFMT3hDdDJiRk94c3Q0QWpEb084ZHk5WHNTMWk2d3BxSFBHczhJbEFxdVMyQmdPM09HV09xMU8ydlpsd2c3dTFJRklmYWFmbWN1NUtteXZRY3c?oc=5" target="_blank">Spliceosome assembly: The unwinding role of DEAD-box proteins</a>&nbsp;&nbsp;<font color="#6f6f6f">ScienceDirect.com</font>
<a href="https://news.google.com/rss/articles/CBMibEFVX3lxTE1oam9PcVRHeV9hNVkxZW95OTI1ZVZxQzFIdW1SUV9XbDd0OVBhdDJGTm5aYXF1ZFlGSmJhMG9pcERja0pyVkRyOFBOQ085Q1o5Rm5pa2RINGZUYkV1Mzdoc2ViREwzZ3dxN2p4YQ?oc=5" target="_blank">Alternative Splicing of Exon 23a in Neurofibromatosis Type 1 Pre‐mRNA: Its Contribution to the Protein Structure and Function of Neurofibromin</a>&nbsp;&nbsp;<font color="#6f6f6f">Wiley Interdisciplinary Reviews</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5mTmM1anRWVWJCZmdvY09FZWFXaUJKaEdjZ19QMGhVWjBjRFBJc1A1V0V4dTBUcndKQmN4YWgtR2taNFl2VEMxZmQ3akUxR3BzZTFsRnk1ejRoa0d6c2tV?oc=5" target="_blank">psiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiXkFVX3lxTFBTNllscFVlTUY5X3NMZDdObHpFbkd4cFZNS0ExMmwtNG5kd2p4bXQ3MzZqNVFqSDZLTDIxc1htd3UtT05kQnVvNVRmQUhmRnF5WS1GRWlIWFN6TE91dHc?oc=5" target="_blank">Yigong Shi’s group reported the first atomic structure of human spliceosome in a Cell research article</a>&nbsp;&nbsp;<font color="#6f6f6f">清华大学</font>
<a href="https://news.google.com/rss/articles/CBMiV0FVX3lxTE93dERjcUxIY05tTmhHUHFGU2FVNHNkTlVMZ2xIZ2Vqb2c3MkZHTkphYlR1THgtVTRpSnV2Y0J5UnRqbFlhdVpncjBqZUFkZUZDS0tBWDNRWQ?oc=5" target="_blank">Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease</a>&nbsp;&nbsp;<font color="#6f6f6f">Journal of Neuroscience</font>
<a href="https://news.google.com/rss/articles/CBMiXkFVX3lxTE9UT2RPMXk4WE5JLTM2YUN5eFBCU1dsSGNVTzZmdUtOMW9ISjN3ZEJ3OTJ5MW4tblJOdS1jWk10WjN2eVNLNEgzelctM0pQZFdKa1hnMEZvNkpUaFN3Z3c?oc=5" target="_blank">Structures of the human pre-catalytic spliceosome and its precursor spliceosome</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>
<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE9iUHR3am5ub0t3cktSeEk2U1pVMF9VaWdXNFlWS0JPQXh5T3pRZTZjemZjQ09icGpDazVUeEliQVY2TGFmZy1UdTh5R2pIY0kzQzNWaFJ5VGZFSV94?oc=5" target="_blank">Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5′ splice site and branch site</a>&nbsp;&nbsp;<font color="#6f6f6f">PNAS</font>
<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5TV0JBSW81bm9FVjNqVW9sanhRSjQ0UUhOZE1wZnctNWtEaW1OQ04yd2YwN2t5Uk5BRDZlNnZYY3NGU0ZCM3JNSGpjRUFoQTQ3YUdLbFRBQXMzNkIwNkRz?oc=5" target="_blank">Structural insights into human exon-defined spliceosome prior to activation - Cell Research</a>&nbsp;&nbsp;<font color="#6f6f6f">Nature</font>