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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Optimizing mouse models f" (30 stories)

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Optimizing mouse models for mRNA vaccines: addressing dose translation challenges
Lead StoryNaturegeneral
May 5

Optimizing mouse models for mRNA vaccines: addressing dose translation challenges

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5FR2VJbU55aTZpRDQ2c1BRWDBEcVBhMlY4RFlXVHd1ckpTUjVTRkpuSklTUGZVVm5RWGFqUnJESGRraWVTOWtEWTBfNTM2anluTXZuVnBRQ1JHNXdpQU5n?oc=5" target="_blank">Optimizing mouse models for mRNA vaccines: addressing dose translation challenges</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "Optimizing mouse models f"

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29 stories displayed
Optimizing Alzheimer’s research with APP/PS1 and 5xFAD mouse models
News-Medicalgeneral

Optimizing Alzheimer’s research with APP/PS1 and 5xFAD mouse models

<a href="https://news.google.com/rss/articles/CBMisgFBVV95cUxPREZPY0ZRYVZrT0pHZWxuZVpNT0V6NE4xYUt2SnRvVEs2WHB2cC1mam5lVHVzYVRjLTdVZDdHdVNVMXVYd1c4M1JxYU9WakJWYU9Va1Q1a1d4MjFsS3VVVzlmanRpaTRSR0dQeFJJRjd6ZjduZ1ZfeGxFNWxzVUhCQXBoRmpwcFpuS21KNGdQdFhXLUJpOU1HYm5MaWVDa1B0MGZaUDVHX0t1RDFnWmFjemNB?oc=5" target="_blank">Optimizing Alzheimer’s research with APP/PS1 and 5xFAD mouse models</a>  <font color="#6f6f6f">News-Medical</font>

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Gouty arthritis animal models: limitations, challenges, and optimization strategies
Frontiersgeneral

Gouty arthritis animal models: limitations, challenges, and optimization strategies

<a href="https://news.google.com/rss/articles/CBMinAFBVV95cUxOQXl5LUZOSnZYeWt2bE1FX3gya2Q1R0JqTktreF8tM1REZ21HYjEtQTdRTktVTFdBX1ZlRGxoS2lDeHNOWHZiSk5lT1pmVjBVb1g2R0FWSXAwTTVQNHROMkNmeVBlV2lZdVpLSVlzS0RtdkNzMnYxclpmakRoMWVSWVN1b2VCYWw1MGpZV0pHbmpxdEpWaHVVQTZ5R2U?oc=5" target="_blank">Gouty arthritis animal models: limitations, challenges, and optimization strategies</a>  <font color="#6f6f6f">Frontiers</font>

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Optimizing CRISPR precision in mouse embryos via microhomology-mediated end joining-dominant targeting
Naturegeneral

Optimizing CRISPR precision in mouse embryos via microhomology-mediated end joining-dominant targeting

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBMZnc2Q1dscV92bDdPRF9wRE12bFU5QmsyRE5Qdm5faVdmaEFwVVBnMjNXaG1keXFsN2ptcTNGb3ZtT2c1QzVHSWZxWEJ6OXRKYUNYTDhKQmF2WF9POWRN?oc=5" target="_blank">Optimizing CRISPR precision in mouse embryos via microhomology-mediated end joining-dominant targeting</a>  <font color="#6f6f6f">Nature</font>

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A generative artificial intelligence approach for peptide antibiotic optimization
Naturegeneral

A generative artificial intelligence approach for peptide antibiotic optimization

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9iWE0zbF96YVpBVnowaGJoU2w4NDEyR19fVTdNcXFIVmlMY1dZSEdpVDdJaHNKSW9Xa08xLU9jOURKZWZfWmEyUF9XMC00TFhxWHUxa3UyblA2VHNHa0s4?oc=5" target="_blank">A generative artificial intelligence approach for peptide antibiotic optimization</a>  <font color="#6f6f6f">Nature</font>

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An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection
ASM Journalsgeneral

An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection

<a href="https://news.google.com/rss/articles/CBMiXkFVX3lxTFA3bHFvZjJ2SXhNbmdpVUhrZFFXVUYwcXZiR3QzUm54YnJhUGZ0RG1TSjBZYVIyTmNfa3c5VGRuczlrRl8xRldDMHZyVjNkMk5MZXJWajl6akRhNXZ3c2c?oc=5" target="_blank">An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection</a>  <font color="#6f6f6f">ASM Journals</font>

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Animal models for diabetic kidney disease: perspectives and prospects
Frontiersgeneral

Animal models for diabetic kidney disease: perspectives and prospects

<a href="https://news.google.com/rss/articles/CBMinAFBVV95cUxPVVdpR05lQlpsQmVPbFMxRjVjVGttclVsT1hjWDZ4RXU5ZDlmQzVPT3dwcWtTSFlCbU1OM3ZNY085cmhpVEtEUXJySlg3Z1RRMVA2bmYwNUtjdXJBYWE2d2hVSHpUUjJRWXkyQTlXLUdZX1JOV1BueUZCYk5hRm53X1gzVDZjekpCc05VNnhhMHFCblFySmhWMmFQLWo?oc=5" target="_blank">Animal models for diabetic kidney disease: perspectives and prospects</a>  <font color="#6f6f6f">Frontiers</font>

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Deep generative optimization of mRNA codon sequences for enhanced mRNA translation and therapeutic efficacy
Naturegeneral

Deep generative optimization of mRNA codon sequences for enhanced mRNA translation and therapeutic efficacy

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE84U0lENVFqN0dHenozNlNMX2JwY2RIaUY4ZFBjUUUyOGZHZUU3MXpWdTk4WVQ0S1ZFUlc4ZGF6bFJQWnFRS0stVDNqb3FBYmVVdm90NUZBbU5FcnFUNXBj?oc=5" target="_blank">Deep generative optimization of mRNA codon sequences for enhanced mRNA translation and therapeutic efficacy</a>  <font color="#6f6f6f">Nature</font>

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The progress to establish optimal animal models for the study of acute-on-chronic liver failure
Frontierstech

The progress to establish optimal animal models for the study of acute-on-chronic liver failure

<a href="https://news.google.com/rss/articles/CBMijgFBVV95cUxON1NwOVlNdUFiTERqdExvWG9wRkxkcHdmc2Q0eGVTTUZhb0NvR2VCUkFDQ04ydzlWS25YV0Q3X2hnUVRNQTZuZ3MzOUc2LUdQNGswaG1LRXhwWDctb20tSmFFc2Zsb2pWRnNEaExMaUlFaDFIR25ESDVHaFJESjlTVlFfV3FSX0tDQmNmZnF3?oc=5" target="_blank">The progress to establish optimal animal models for the study of acute-on-chronic liver failure</a>  <font color="#6f6f6f">Frontiers</font>

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Codon-optimized human Smad7 gene therapy enhances skeletal muscle mass and function in a murine model of Duchenne muscular dystrophy
Natureworld

Codon-optimized human Smad7 gene therapy enhances skeletal muscle mass and function in a murine model of Duchenne muscular dystrophy

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5yWFMtcjJzdHpKUlQ2OEVtNHJQclRFYXZyckpLRHBMa2RHd01TSVRJWmcwbVRzRDhESFhQNHFxRFVJaURiQkR4MU1lNTF4UjBFOV9HaGdmbzZzeUZmWnRR?oc=5" target="_blank">Codon-optimized human Smad7 gene therapy enhances skeletal muscle mass and function in a murine model of Duchenne muscular dystrophy</a>  <font color="#6f6f6f">Nature</font>

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Refining the adjuvant-induced rat model of monoarthritis by optimizing the induction volume and injection site
Naturegeneral

Refining the adjuvant-induced rat model of monoarthritis by optimizing the induction volume and injection site

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9hRUFaSU1CS2paWWtBSW52TDFfcU5UcWF2ZkxyeTJrQTdiaUREVXR0amc3ck1yeG5iM0NpZXI1NmRaQWY2SjBTenZrNE15VC1xdmJqS09ERElBbVVtbndj?oc=5" target="_blank">Refining the adjuvant-induced rat model of monoarthritis by optimizing the induction volume and injection site</a>  <font color="#6f6f6f">Nature</font>

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OBSERVE: guidelines for the refinement of rodent cancer models
Naturegeneral

OBSERVE: guidelines for the refinement of rodent cancer models

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE56QXhadTRKOTByT0xtZHlxa0xlWVVUNWNZQVBsWkdlbEF2d3ZYVHozT0FQdE9GN2YwdG5jZnNiVzBEVktNOVJySkZiSHY4Y0dKOU5qNEZ0bXI2RWdDRGt3?oc=5" target="_blank">OBSERVE: guidelines for the refinement of rodent cancer models</a>  <font color="#6f6f6f">Nature</font>

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Optimal fasting duration for mice as assessed by metabolic status
Naturegeneral

Optimal fasting duration for mice as assessed by metabolic status

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5LNTh5b3ZaOHZzLVFFOXpJbWFSOVY0RTlGS0hGZVNLX2dvLWJRdkFfa0FQUWdHY1dqZlB6NDZ2a3J5VVdZTGhVc1Z4WldPb1pVcFdoVnlYdFUxZ2toV0Ew?oc=5" target="_blank">Optimal fasting duration for mice as assessed by metabolic status</a>  <font color="#6f6f6f">Nature</font>

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GFP-on mouse model for interrogation of in vivo gene editing
Naturegeneral

GFP-on mouse model for interrogation of in vivo gene editing

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBJeGVOb0JqUGNkMmNHQmpUaVR1UU5tT1dsdXZjRVhzRk5ncVQ0cGFpZGdSRncxX2hfNVRnQTJnbmhUcFAwb1Npdk9aY09OX1BTT0Uwb00tOGs4RDVxU1d3?oc=5" target="_blank">GFP-on mouse model for interrogation of in vivo gene editing</a>  <font color="#6f6f6f">Nature</font>

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Optimized in vivo base editing restores auditory function in a DFNA15 mouse model
Natureworld

Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1jaXA4M3JXLTJnaHBEYkMya2hINUdnMk9TcEdmbGRCc2VMNjMteERlM2N4cUI1X0ltTUs1NGlhX05zTTdtX3ktTmdoMXEzWmlsYWpocVp4RnNiRERFaE5v?oc=5" target="_blank">Optimized in vivo base editing restores auditory function in a DFNA15 mouse model</a>  <font color="#6f6f6f">Nature</font>

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Optimized cesarean techniques, IVF use, and foster strain selection enhance germ-free mouse production efficiency
Naturetech

Optimized cesarean techniques, IVF use, and foster strain selection enhance germ-free mouse production efficiency

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ZY2VkREJMZkYyZFpmZjJrMFFWX3JhWnp6U0FsSmdUWVRrZkpiMXlxUFFSZndnWkVBZmlQUFRkSVg5aUJ5MkU1dU1IdjZ2SkJKanlfWE5Dcm1sVWQ2V1lr?oc=5" target="_blank">Optimized cesarean techniques, IVF use, and foster strain selection enhance germ-free mouse production efficiency</a>  <font color="#6f6f6f">Nature</font>

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Optimization and evaluation of an experimental subarachnoid hemorrhage model in mice
Naturegeneral

Optimization and evaluation of an experimental subarachnoid hemorrhage model in mice

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE4yNV8zY0NPWVJORzA1S2owMUlJZmxGQ1daVGJnMFZELUpRX1NLTlp4c3VHN0Y3TFpTUEJ4cHVVTDN2YnVrOU1KSDVUUUJzYnc5NVpqekZfS3FvZXJRbmtN?oc=5" target="_blank">Optimization and evaluation of an experimental subarachnoid hemorrhage model in mice</a>  <font color="#6f6f6f">Nature</font>

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AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models
Natureworld

AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBXVjdEX2xad3JaWHdielBUOE43VndqWXVLbWFXVURrcUxkMTRlWURGLXItWUM3eTk4M2l0b05RSThaSHRuWHpQY1dyTjAyQ3NSRkZOSFQ4amhXRUozakg0?oc=5" target="_blank">AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models</a>  <font color="#6f6f6f">Nature</font>

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Fc-optimized GITR antibody enhances a CD4 T cell–dendritic cell crosstalk to promote antitumor immunity
Natureworld

Fc-optimized GITR antibody enhances a CD4 T cell–dendritic cell crosstalk to promote antitumor immunity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1JQ05sX2tLV2pMcnk2MTd6blhHelZqYzhxUG9IOGM2dmdKZ3hmZFg4d3l3UUxXaG9NYlYxZnU2MVpTTm40NXRHbzVCcVdGclZMVjdOeWJEVFB1YVNLZ0F3?oc=5" target="_blank">Fc-optimized GITR antibody enhances a CD4 T cell–dendritic cell crosstalk to promote antitumor immunity</a>  <font color="#6f6f6f">Nature</font>

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VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response
Naturegeneral

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE52MnRQWTFyMWNVbGU0bVc0c3hraGh4dkw5TWVWQUlDRGNfRndlTFJlX3lYT3ZiaXEzWG43Yjdlb1pyQ3lEbnA0TUF5bVY1SzFfX29ydUVPQWdsRHNJUlJZ?oc=5" target="_blank">VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response</a>  <font color="#6f6f6f">Nature</font>

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Optimized clonal isolation and immortalization of Rett syndrome patient fibroblasts for in vitro modeling of MECP2 mutations
Naturegeneral

Optimized clonal isolation and immortalization of Rett syndrome patient fibroblasts for in vitro modeling of MECP2 mutations

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFA4YTlxd1FUQ19aYnZPcGJEVHhfdXAyYnJiQ2cyYkg1VEdzWENoa19ua2h6N2dteXN3T1pZRjBXaWVPU3Y5MEE5Q0luUnBSbWw3bmtUUl94UXg2RkYzUHNn?oc=5" target="_blank">Optimized clonal isolation and immortalization of Rett syndrome patient fibroblasts for in vitro modeling of MECP2 mutations</a>  <font color="#6f6f6f">Nature</font>

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Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis
Naturegeneral

Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5BVEpHYWwwaXRZQ205Y05LMV9pSXljZUtsd2dnZVJlc3UyOFNiYm1Bdk5kdFlsT3NGcGZ4RGU2NXQ3SkZWcVhwZV9fWlVNUTBrQVNnaURSMDUzVjh3WEhB?oc=5" target="_blank">Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis</a>  <font color="#6f6f6f">Nature</font>

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Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model
Naturegeneral

Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFAxQTVEWS1DdXp0MGdxWjZFcXVvUVl1Zk1uN3JINnlzMl82UVBjM2tOU2s1LUF0MmNIS1RIcnZLRXZmM0VvZkgtMWZvWFBieTA4d1VSTVBYT3V0dzJlbnZB?oc=5" target="_blank">Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model</a>  <font color="#6f6f6f">Nature</font>

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Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models
Science | AAASgeneral

Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models

<a href="https://news.google.com/rss/articles/CBMiZ0FVX3lxTE5MdmkzSUxXVFBDaGFfMWhiVUMzcURBQWxCbjgxQ2RFOUpIRE0zYTBVR1lOcDZmc3Y0SGotNG5sLUgyY09nS2NzcGN2NU1Rb081VlJBTGxUNFRBRlUzY1F4SDN0OW9SLTA?oc=5" target="_blank">Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models</a>  <font color="#6f6f6f">Science | AAAS</font>

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Optimizing anesthesia and delivery approaches for dosing into lungs of mice
American Physiological Society Journalworld

Optimizing anesthesia and delivery approaches for dosing into lungs of mice

<a href="https://news.google.com/rss/articles/CBMidkFVX3lxTFBxT3k2R3lhMU9QcDFsRXJXSUp1cXVaOThlcHZFNG9RVERXamZONXk4YjF1NXBtRzJsR0gwdzJaNXBXOWI3VGFXTzlLVkY0V0M0OGV6Y3MyMFF6X2ZjT1pyS0NFN2lSY0NDdjhTS2RIRVJXLWRrSEE?oc=5" target="_blank">Optimizing anesthesia and delivery approaches for dosing into lungs of mice</a>  <font color="#6f6f6f">American Physiological Society Journal</font>

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Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy
PNASgeneral

Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTFBYM1hzNUpYV0FCNHJsVDhYZ1UzbUduSVFVUTVDcXk3MWRyam5ENzFNUGsxcl9rODdPcExqVmdFT3ZKZFlTbERjUjFpb25FcGtuYnk3RERqWmM4VHNX?oc=5" target="_blank">Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy</a>  <font color="#6f6f6f">PNAS</font>

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Paving the way for better ototoxicity assessments in cisplatin therapy using more reliable animal models
Frontiersgeneral

Paving the way for better ototoxicity assessments in cisplatin therapy using more reliable animal models

<a href="https://news.google.com/rss/articles/CBMioAFBVV95cUxNWDB2UmpxRlhSMzZtV0g2eEV4YXllVU1MRV9KTV9NVkhneVdzSEs2cTZVb2s1bkpVU0RRR000R0ZRQUpTcnI4LTBiaEVQanVOZG8tZDg4QTVsaW9Uc2JMY0hlVmMtWG52bktkdGhkN2JYNmZ2Zl9ic19jbk13YXhRUHFrcnp5R0pqRU84LVBaOC1TbTMzZlZhQ0syNzdhbGZB?oc=5" target="_blank">Paving the way for better ototoxicity assessments in cisplatin therapy using more reliable animal models</a>  <font color="#6f6f6f">Frontiers</font>

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Micro-CT-assisted identification of the optimal time-window for antifibrotic treatment in a bleomycin mouse model of long-lasting pulmonary fibrosis
Naturegeneral

Micro-CT-assisted identification of the optimal time-window for antifibrotic treatment in a bleomycin mouse model of long-lasting pulmonary fibrosis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1QUG9KSjR1MHFXY3JkU1hfOXhWcGc5TmhXSUxjMUs1b1hpNnhaVHZWN0h3RFdkTXVvSEh6YWtaaVRXQV9QX1N1di1qSVMyVEtrcDYwblNlaE81MTJyblYw?oc=5" target="_blank">Micro-CT-assisted identification of the optimal time-window for antifibrotic treatment in a bleomycin mouse model of long-lasting pulmonary fibrosis</a>  <font color="#6f6f6f">Nature</font>

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Glial cell reactivity and oxidative stress prevention in Alzheimer’s disease mice model by an optimized NMDA receptor antagonist
Naturegeneral

Glial cell reactivity and oxidative stress prevention in Alzheimer’s disease mice model by an optimized NMDA receptor antagonist

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9tZWo1WXdvTXBGTUM2QzhIY0puUHRQOEtBZFJrRlYxTWUxYjJqdnltMjE5d3B3a3NnbXp2VThjYnNHdUxta1ktR1RtTkI4WGc5LXNjdkNPdEpGb2ZPNjBv?oc=5" target="_blank">Glial cell reactivity and oxidative stress prevention in Alzheimer’s disease mice model by an optimized NMDA receptor antagonist</a>  <font color="#6f6f6f">Nature</font>

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Optimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis
Naturegeneral

Optimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9IbFBwT0U0U0tlVUpoa1ZuR0ItZG9wUzI1ZEd2U2FzNTB2SUpCZ2swVXcxWHRicWZJVS1wSk04NnNGblhNeEZVS2NqVGxEMk54dXNkOTFuMGRVRTV6cm5n?oc=5" target="_blank">Optimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis</a>  <font color="#6f6f6f">Nature</font>

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