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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Mutations in COPA lead to" (30 stories)

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Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors
Lead StoryNaturegeneral
Jun 12

Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9LVUZjZGlSQlpuNnh5TTg0QkltdDdiTzV3QlQyMUVGQXozMGtqTFJpUG1EQzN1Mlg0M1duNTZTOC1jazE2dERJU2hUYVRMZTZKbnd3dnM3blNqanNHU1g4?oc=5" target="_blank">Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "Mutations in COPA lead to"

Updated every 3 minutes via FreeNewsApi, GNews, Currents API & Google News

29 stories displayed
The STING HAQ haplotype and clinical non-penetrance in COPA syndrome | Journal of Experimental Medicine
Rockefeller University Pressgeneral

The STING HAQ haplotype and clinical non-penetrance in COPA syndrome | Journal of Experimental Medicine

<a href="https://news.google.com/rss/articles/CBMimwFBVV95cUxQcEVRTVRuMHRNQmp1TndrbTVoNVNXbnhId3hicDlkUVlKQjh1VFI0M0txMFd2UVNRd2dyMVhpOW1NZGlPU3ZreG5MMGthSVBucHFNXzJxNGJoc19iRGlXR1d4M0prYnFHM0o3YkJnaGpXNzdpRzA2N1VXVlI3S2lsUkFhZjZCX1hVblJkamZmVk1JNUhNbmszak55Zw?oc=5" target="_blank">The STING HAQ haplotype and clinical non-penetrance in COPA syndrome | Journal of Experimental Medicine</a>  <font color="#6f6f6f">Rockefeller University Press</font>

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Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling
Rockefeller University Pressgeneral

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

<a href="https://news.google.com/rss/articles/CBMiqAFBVV95cUxPUHNta2llY2h0d2NQYkRjNVhyX1pNaHRWNWxPNTVPNzA3Z3dWT0FyQUtETGxoRW9abzhwRlhPaDFrMFQ1WTVST2Nha2dQTlBrWmU3MGlncXVLazBjT0lrMFVfWTJIT2tEc1I2U2NiQUVHZmtmVk9vcENhekkyNTFtS3pPd3dyWHJQZC04OUV3VklqVXQ3dU0wYXBWUjQwdTZxNzBZV1lTWDU?oc=5" target="_blank">Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling</a>  <font color="#6f6f6f">Rockefeller University Press</font>

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Pharmacological stabilization of hypoxia-inducible factor 1-α dampens the interferon response and promotes glycolysis in Aicardi-Goutières syndrome
Naturetech

Pharmacological stabilization of hypoxia-inducible factor 1-α dampens the interferon response and promotes glycolysis in Aicardi-Goutières syndrome

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5pMVhtLVBXOTB4LTZzdExEeUR0U0EwYWRJUDNpWGdQNnFzdXBsUGhlRzI4M2NmdHpyUXhBZ0FtMTg4VWFMOUwzd1RTODZtNHc0aWp3TFBIZ1RJeGJFejVF?oc=5" target="_blank">Pharmacological stabilization of hypoxia-inducible factor 1-α dampens the interferon response and promotes glycolysis in Aicardi-Goutières syndrome</a>  <font color="#6f6f6f">Nature</font>

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COPA syndrome caused by a novel p.Arg227Cys COPA gene variant
Wiley Online Librarygeneral

COPA syndrome caused by a novel p.Arg227Cys COPA gene variant

<a href="https://news.google.com/rss/articles/CBMiakFVX3lxTE1FS1BJWlRBMjRVZzMwQlJVaVUzMlpDUHlydXZINm0xSUFuQjJZcUNGV3k0bHozSkJOZnM2Nk1HYmpaYTUtWUpiWGowVDA2RHVTZTctZVh3UGpDYldCcHFuQjkxeW5kTjNvaGc?oc=5" target="_blank">COPA syndrome caused by a novel p.Arg227Cys COPA gene variant</a>  <font color="#6f6f6f">Wiley Online Library</font>

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Gene variant shields against COPA syndrome, a devastating inherited disease
Medical Xpresstech

Gene variant shields against COPA syndrome, a devastating inherited disease

<a href="https://news.google.com/rss/articles/CBMihAFBVV95cUxOZlpHMV9pcUd3Nm9TZExfMTMtbWxwSzVObWxhUDM4MXNIbE8tY0xLbEJaZXNVSTJzUDItVUxYWTAxd2RhbHJhU1JxUENBa0tFcEVWNEJpSTAzc1NHbDRGOEpLMVF3cEtkN2dpclR6eWc4dGEtdjhmd1VsWlVHYUY3bDVWREw?oc=5" target="_blank">Gene variant shields against COPA syndrome, a devastating inherited disease</a>  <font color="#6f6f6f">Medical Xpress</font>

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Traffic jam within lymphocytes: A clinician’s perspective
Frontiersgeneral

Traffic jam within lymphocytes: A clinician’s perspective

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxNY2pONWFJT0xJQVpVOGVKcVBZT19ac0pPc2dQTk5hYWlSUDZ2clhyVDhUQ0drdWlwSTdSa3JxMk4zT3ZUQlpPb21UM2s5MW1jbjZIak1QdlFON1JvUmtmNDU5MHVjbUxvbXFGV0lGQkJqTEthRVVmbGg5d0czbVBoOHRQdWNpU0MyRjJRQzN3ck5TUQ?oc=5" target="_blank">Traffic jam within lymphocytes: A clinician’s perspective</a>  <font color="#6f6f6f">Frontiers</font>

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Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling
Rockefeller University Pressgeneral

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

<a href="https://news.google.com/rss/articles/CBMickFVX3lxTE1SOG55bjZVNU1EeEZRVDkwYURzRklMQm9pSHRvU1FRMGcxLXllQjhjc0V1Ul9NRGd3YzhyUm1tSnRDd0wyVWFheDg2Q25tNjZPOVdRcF9QaUplM0ZrRmdzSjR0RGo0Ykw2MzVmVEplUmgxdw?oc=5" target="_blank">Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling</a>  <font color="#6f6f6f">Rockefeller University Press</font>

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Respirology Case Reports | APSR Respiratory Medicine Journal
Wiley Online Librarygeneral

Respirology Case Reports | APSR Respiratory Medicine Journal

<a href="https://news.google.com/rss/articles/CBMia0FVX3lxTFB4Rks3UXZwMU5QTi05VEZUX0xzMjVNczZwMXdfVmhZNUFfYTM0YUZNTkFqWV9ta2RqUXBEdDAzWWlhdGZDamcydW02Smktbzl6RVJxUEVfdmNqcFd3RDVTN0FIcy1iNUdKUlVv?oc=5" target="_blank">Respirology Case Reports | APSR Respiratory Medicine Journal</a>  <font color="#6f6f6f">Wiley Online Library</font>

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COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis
Naturetech

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis

<a href="https://news.google.com/rss/articles/CBMiUEFVX3lxTE1KN1c2bEQ5SldUR0RLdzNRdEh1ZzhabFNSaHNKdHg1cW1DR1NkcHdwdkNFZXc1dGFNdUdQUDV4Z1FvX29CYUVYVlRGUVJmMFo2?oc=5" target="_blank">COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis</a>  <font color="#6f6f6f">Nature</font>

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Disease‐Associated Factors at the Endoplasmic Reticulum–Golgi Interface - Maeda - 2025 - Traffic
Wiley Online Librarygeneral

Disease‐Associated Factors at the Endoplasmic Reticulum–Golgi Interface - Maeda - 2025 - Traffic

<a href="https://news.google.com/rss/articles/CBMiakFVX3lxTE5XNEMwd2Y5VVUzSW5xa29Wc2FVOHdleXdqYkR0ZlcySlZweHhESnRQaGRQRDVMbk82bmdiODN5dEtEVFloYkpkNnQwVm84MWRwX0hqT1dlM0tnQWZoVWl5NExwdGMtcmZqMVE?oc=5" target="_blank">Disease‐Associated Factors at the Endoplasmic Reticulum–Golgi Interface - Maeda - 2025 - Traffic</a>  <font color="#6f6f6f">Wiley Online Library</font>

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COPA silences STING | Journal of Experimental Medicine
Rockefeller University Pressgeneral

COPA silences STING | Journal of Experimental Medicine

<a href="https://news.google.com/rss/articles/CBMimgFBVV95cUxNUkJfUktDbG96S1FIaW4tOHg5dU5JbDEyMFl3MVpwckVBSTVCX1VoQ3VjMjBCdFZsakJlS0UtTmNYdXptSVEtWFVYT2x6Sng1b0NmS2ZqLThILXFiZTZ3WkhHTVBwcENrZkRqb1R0YnBWTVVYbzktLU5uUUpnWnRDcEZwcDNqaHVQZlhvd2FSUDF3Z2pybllQR0lB?oc=5" target="_blank">COPA silences STING | Journal of Experimental Medicine</a>  <font color="#6f6f6f">Rockefeller University Press</font>

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Deficiency in coatomer complex I causes aberrant activation of STING signalling
Naturegeneral

Deficiency in coatomer complex I causes aberrant activation of STING signalling

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE03V0xEQmxnbXBGbE1qTnZNNDFCUnRVTHdma3VhSHhodDdhRnhIRk9EMWxFRDZrNDVmdFJLWGN2UnZGVGNCdHpkb2FVYVF5VHYxRTQ0VmxrNXJPSUM0d1h3?oc=5" target="_blank">Deficiency in coatomer complex I causes aberrant activation of STING signalling</a>  <font color="#6f6f6f">Nature</font>

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A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome
Rockefeller University Pressworld

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

<a href="https://news.google.com/rss/articles/CBMiogFBVV95cUxOUTB3LTFmNmsweHFLRGVpdjNjdmtxMmdGWlJNdGh2aHhuU3dKYlNYeC1zTGU0VnpMSTc0LVB2TEdvUlVJOTNjNk1MTTdDMl9JeVhJV1pUam5VTlNBeXJqeHBpa2tGMTdDbUFpbnVqU0xLOXJkbWJxZDlNUE1vYVY0dW9LOThESk9kTV95b20tWGF5U3ZiQXhSUTNkUk5yd3FaTVE?oc=5" target="_blank">A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome</a>  <font color="#6f6f6f">Rockefeller University Press</font>

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Homeostatic regulation of STING by retrograde membrane traffic to the ER
Naturegeneral

Homeostatic regulation of STING by retrograde membrane traffic to the ER

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE52MDVrZUZoOXlBX1Bsam8yQ0tPWmg5b1ljeVVic2lyUXJwTDAxemp6dUpTLXpfUHMxMmlTWTBiZmo5U2JUUThLckk0bjdfeUExNzlmcmN6RWRlN1hyM2U4?oc=5" target="_blank">Homeostatic regulation of STING by retrograde membrane traffic to the ER</a>  <font color="#6f6f6f">Nature</font>

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Autoinflammatory patients with Golgi-trapped CDC42 exhibit intracellular trafficking defects leading to STING hyperactivation and ER stress
Naturegeneral

Autoinflammatory patients with Golgi-trapped CDC42 exhibit intracellular trafficking defects leading to STING hyperactivation and ER stress

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE4yN3dVOHItekZtaURpVVp4WnJla1VEM3kta0NrX2tGU3Izb1NVbG05X1Z2b0tfQ3VIZ0M4SXp5dGxTM3ViZFFMaktrZ2lwNnRpc0R4SkpRNG9GY2hDS0xB?oc=5" target="_blank">Autoinflammatory patients with Golgi-trapped CDC42 exhibit intracellular trafficking defects leading to STING hyperactivation and ER stress</a>  <font color="#6f6f6f">Nature</font>

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STING trafficking as a new dimension of immune signaling
Rockefeller University Pressworld

STING trafficking as a new dimension of immune signaling

<a href="https://news.google.com/rss/articles/CBMiowFBVV95cUxQeXB5VVpTQTBTQkFYejFISFlzR25YWVNUajAzc1paeVprQ3AyamlVUVJWd1dGTktFWjN6UmhQME5iSnZoZEVLYmFmOTdNenpLYmhuUm9aUXRKYnd2Q21yOVdzXzktaWFsMkRBM3pfVVFyek5rajhmakdJQ1VqVFVYVVlVaGs1dUVNM3Y5Y19TSEJ1VDVJVi1EWlA1UlVHRE42WVdv?oc=5" target="_blank">STING trafficking as a new dimension of immune signaling</a>  <font color="#6f6f6f">Rockefeller University Press</font>

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The type I interferonopathies: 10 years on
Naturegeneral

The type I interferonopathies: 10 years on

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9CRWxYZHZHa0RYSkpiaExhYnNmVTZ5dk9iNFVsNWs4a3pVU3oxWFF0MG1INDBndHRQRXJXMDlFOUJqWHphejFpMmZtX0R6N294VXJrUGNVRjJPMWxGQmk0?oc=5" target="_blank">The type I interferonopathies: 10 years on</a>  <font color="#6f6f6f">Nature</font>

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Rapid Discovery of De Novo Deleterious Mutations in Cattle Enhances the Value of Livestock as Model Species
Naturemarkets

Rapid Discovery of De Novo Deleterious Mutations in Cattle Enhances the Value of Livestock as Model Species

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9pZjk3V21IYUFMRlJEcnZXZG9FRWhzcENVX1drN2V5V29MdHdmN3RDMDBLZ24wUEhNS0xjdjhubERwMjVNZ1VHMkZkNEpBVTd3aDNRMzRwc0o4RHNkWmZJ?oc=5" target="_blank">Rapid Discovery of De Novo Deleterious Mutations in Cattle Enhances the Value of Livestock as Model Species</a>  <font color="#6f6f6f">Nature</font>

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Identification of mutant gene for Black crystal coat and non-allelic gene interactions in Neogale vison
Naturegeneral

Identification of mutant gene for Black crystal coat and non-allelic gene interactions in Neogale vison

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1JLXBRcnBYc2tWS0Z2dlFWQXFEc2RGT0dudUlUc045Uk5RbUM0YjVTbVVzeTNnR0xBQ3VvVWN0NzlYZWJUOC1XbmQ4dlhJRGg2S0hmaFhFYUJObGZKRFBF?oc=5" target="_blank">Identification of mutant gene for Black crystal coat and non-allelic gene interactions in Neogale vison</a>  <font color="#6f6f6f">Nature</font>

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A novel STING variant triggers endothelial toxicity and SAVI disease
Rockefeller University Pressgeneral

A novel STING variant triggers endothelial toxicity and SAVI disease

<a href="https://news.google.com/rss/articles/CBMingFBVV95cUxNbmFOVHBmNlpkMU43VjRLYWZQQ2lzN2c2WFVnNVNDRUhPeTVvaXh1cU9ELWMyWDBGN1pNQ2x6ZXNwdmFSUXRtRnU0UGtUY1hpSDdTSjJCT09XNHIya2JNMHdoUHFYSnhIa05OZlVPbWtwUllKekZpNklYMklEQlNMQ3VQZmo4OU90dmo0WWVIMm9Kc3VZdDRmeFRlRXdVQQ?oc=5" target="_blank">A novel STING variant triggers endothelial toxicity and SAVI disease</a>  <font color="#6f6f6f">Rockefeller University Press</font>

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COPZ1: an example of non-oncogene addiction in human tumors
Frontiersgeneral

COPZ1: an example of non-oncogene addiction in human tumors

<a href="https://news.google.com/rss/articles/CBMilAFBVV95cUxNNTdmMmJKWUE4c0JkNkt2SHRoYjZPbWllRXJBOVZHNFBRZGI0cEpNZXVNU2daNjk1SWUyMEprd0dybkp0clYteUYzMFhwbXZFTkpZbWpEVVB3c0M3djl4TksxMktQZWlQM1h4SDJRSE1yR0FybkpXb2RMUmFpTU5ZSklmS1h1TURIQkZnQ1A5OXQxaVFR?oc=5" target="_blank">COPZ1: an example of non-oncogene addiction in human tumors</a>  <font color="#6f6f6f">Frontiers</font>

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Non-infectious mixed cryoglobulinemia as a new clinical presentation of mutation in the gene encoding coatomer subunit alpha: a case report of two adult sisters
Frontiersworld

Non-infectious mixed cryoglobulinemia as a new clinical presentation of mutation in the gene encoding coatomer subunit alpha: a case report of two adult sisters

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxOYlg2Nkh2RVZ5REp2bEd4Y0puTFZ6dWdXUmppSmJfMUIwUWUzaFZZeTNrbzRMcXZhaFRTUVM4azlTSnhqTWJtQm1WeGxKWi1lOVJ2c2M3TnI2VzRITmVERmhfUXlXME5TZ2lrVHVHZWI3Vl9kLUxiMkpMRlltM1Vxc0M1XzhXVm50TzZUbnNpZjI5UQ?oc=5" target="_blank">Non-infectious mixed cryoglobulinemia as a new clinical presentation of mutation in the gene encoding coatomer subunit alpha: a case report of two adult sisters</a>  <font color="#6f6f6f">Frontiers</font>

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ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling
Naturegeneral

ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE03THRpSlhfdUhHR2o3aFJJTUtXSy1laUFLSTNrVS1odzhLVDJ4SDR2T2pUOEpTNzRuVGpMbFYxSEZOekh0LTJFbHF3Y0R2ZjRSRVg5dkd4cC1nZW43WDhv?oc=5" target="_blank">ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling</a>  <font color="#6f6f6f">Nature</font>

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Interferons in human inborn errors of disease
ASM Journalsgeneral

Interferons in human inborn errors of disease

<a href="https://news.google.com/rss/articles/CBMiZEFVX3lxTFA0WU5zaXlsVGwtbzB3UUpwcHZXTGlpMkJGNG80dnBPWkIyWmktNHFZUFd4eldPM0RrN2Q4TTJKSW5hRWQzYjZNZTN4WFR3d1o0SEhqRTZOX3MwdWZHWjM2eFNkaXk?oc=5" target="_blank">Interferons in human inborn errors of disease</a>  <font color="#6f6f6f">ASM Journals</font>

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Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A
Rockefeller University Pressgeneral

Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A

<a href="https://news.google.com/rss/articles/CBMiqgFBVV95cUxNMEtNbUM2Y19xRmJXa0xnZ2lzal9FT25uTloxWmhCWk9YM2xRZExOZmwydDNhYW5CY1VIUVZ5eUkzallqdVdMTllIZE5talpOUERiUlNKWDQ1TkZMRHp5QVJZRjI0YTJ5bUw3X3dLU2Nuc0tjY1dQOUU2elJUZnN0QTl2eGdhTzVQQVNrUWxuZzY0RGdybVlBXzNTd2wwSzlQMlI0LUw1c1RPdw?oc=5" target="_blank">Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A</a>  <font color="#6f6f6f">Rockefeller University Press</font>

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Spectrum of Systemic Auto-Inflammatory Diseases in India: A Multi-Centric Experience
Frontiersgeneral

Spectrum of Systemic Auto-Inflammatory Diseases in India: A Multi-Centric Experience

<a href="https://news.google.com/rss/articles/CBMikAFBVV95cUxOLWt1T29KQWVmVFk2X09PU2hmS0FBSkk3Slp3UzRRcHIyb3JORG92Q0JKaEJsaHFOWHFaTGx6UFRyay1RR2dzaUI2bmlZeXI4eXZJZ3ZveGdoVU5PNF9SeWU2ZEZqZlh1TjJvQXRGdHVNdUxSb1FwYjNhc3R0ZFFHalpWNGt3NTg4YkEwVDZiZFQ?oc=5" target="_blank">Spectrum of Systemic Auto-Inflammatory Diseases in India: A Multi-Centric Experience</a>  <font color="#6f6f6f">Frontiers</font>

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Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation | Cell Discovery
Natureworld

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation | Cell Discovery

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9CSnJfcURTdlJuMWJuejV4cURtTk1JXzBHdU9DOUdlNmdQbHh6UXh6ZE40MUFTYmF5TkV6UVEtc2V3NVVhTjFhV3BCMC1nMmliNHRXdXdpSGVkVzhhTUdR?oc=5" target="_blank">Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation | Cell Discovery</a>  <font color="#6f6f6f">Nature</font>

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Phenotypic mutations contribute to protein diversity and shape protein evolution
Wiley Online Librarygeneral

Phenotypic mutations contribute to protein diversity and shape protein evolution

<a href="https://news.google.com/rss/articles/CBMiaEFVX3lxTE1EeDBEa3ZqbVo1NUQ5SnNuTk5MSmNzQ29DODZKbXRCaXlncmlNQmxIcmVsbzkwMUZudjB5YnFzNy00aF95YXhoRG1fS3F5MUE5SGlaci1nYjVIU2FsbkxRck9sQS1EMm9L?oc=5" target="_blank">Phenotypic mutations contribute to protein diversity and shape protein evolution</a>  <font color="#6f6f6f">Wiley Online Library</font>

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A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease
Natureworld

A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBaenVpTEhwNk0zMzF3RGNkUUVPaHhkbDQ3WEhSa3VuUVFYWW9HTHdrVGpkaDFLOGpBVGlBbnpuY3VnOTJKZWhydUk0VFdMQ252N3BpcHNBWk9pVTJUM1RN?oc=5" target="_blank">A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease</a>  <font color="#6f6f6f">Nature</font>

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"Mutations in COPA lead to" — Live Google News Trends & Headlines