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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Mapping 3D-super-enhancer" (30 stories)

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Mapping 3D-super-enhancers with machine learning to pinpoint regulators of cell identity
Lead StorySt. Jude Children's Research Hospitalgeneral
Mar 9

Mapping 3D-super-enhancers with machine learning to pinpoint regulators of cell identity

<a href="https://news.google.com/rss/articles/CBMigwJBVV95cUxNc1oxaGt4MkdlRTNDblNuRmk3WXotR1JydmZlNXZVLWI1enJEX0MweXpvSTlEVHZtNXpWUmJMZlNWbGRtOFFiX2drV0FqVHF1Y1I0aFlDaXlXS3JpcVM5Wjk1bkUwMkkzOXVmWU5pVndaTE5IanRlb1BwQVU2MlNLelc5WGd4R0x6NGl5ZkNmZWs5YXVoOUNYQVVZb1BqRllQaG93UHpQUGRFeHNPVXpMeFJRSG1Pak4yNXJKS3B4ZXJDVnk3MkhRMmp4R2dHYVNnUzF0RlVKX1J4cWs2TnRSWVRxZURHaXdlREYzNFZyc0dBNE1IbGF3eVhHNlpkSS1GVEFN?oc=5" target="_blank">Mapping 3D-super-enhancers with machine learning to pinpoint regulators of cell identity</a>  <font color="#6f6f6f">St. Jude Children's Research Hospital</font>

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Search Results for "Mapping 3D-super-enhancer"

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29 stories displayed
3D chromatin architecture in cancer: mechanisms of dysregulation and emerging therapeutic strategies
Naturegeneral

3D chromatin architecture in cancer: mechanisms of dysregulation and emerging therapeutic strategies

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBoMEk4REcyMjRDRTlMTVNIRjJCMGdRS3IwanNXYm9NYkJNVnc2Mm0wWTRsZ0RtczliQ2NUb1VOR1hfdmRERGVJWFZZLVRfdGFRekVmcGgwWmtJeFFUQVdn?oc=5" target="_blank">3D chromatin architecture in cancer: mechanisms of dysregulation and emerging therapeutic strategies</a>  <font color="#6f6f6f">Nature</font>

An encyclopedia of human enhancer–gene regulatory interactions
Naturegeneral

An encyclopedia of human enhancer–gene regulatory interactions

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1adExPQnd1RWtqUG9NeUpSTzVnRjJDZ2dBcGd6WVZKejMyYWJub1ZrY0ZIS1JrdDJqY3Q0WWp0elRlRXBuZHB4RHloelpHTk5LMlIwaFdlWWF5SWNJcUo4?oc=5" target="_blank">An encyclopedia of human enhancer–gene regulatory interactions</a>  <font color="#6f6f6f">Nature</font>

Enhancer provides a potential target for “undruggable” MYC in pediatric medulloblastoma
St. Jude Children's Research Hospitalworld

Enhancer provides a potential target for “undruggable” MYC in pediatric medulloblastoma

<a href="https://news.google.com/rss/articles/CBMi_AFBVV95cUxQWUZmM25JYmhBMThkdTZNdkFuLTBmYkE2dm84aG1TT0dnbGVqUWtnU2ZBajU5cGhETXN5NnBzTzJDZFlESWlXWU1tdEtrZ2lrZTFyZWZkRmJVUjZyOE5pRndIaHZMNWVGWnRxRHREdG5mZEVsVWNPNTBMWmstNkNyNXpvd1FwSTV4c2J2Q2Z3MXJaSFhocVk5Z0t1emhVTXhtc1d4eU1yaXRJWkJ4LW9sc2YyMFFZRTFzNzJXNnZWcEh5TWtXTTdFVlJoVE0zeXZNX2NnSDlKYXNZZWFNZVZRWHllSEhIRW9KRl84LVZQYndKbFExcW1LYnJmc28?oc=5" target="_blank">Enhancer provides a potential target for “undruggable” MYC in pediatric medulloblastoma</a>  <font color="#6f6f6f">St. Jude Children's Research Hospital</font>

3D map reveals DNA organization within human retina cells
National Institutes of Health (NIH) | (.gov)general

3D map reveals DNA organization within human retina cells

<a href="https://news.google.com/rss/articles/CBMipgFBVV95cUxOTUg4Z3pxMEJBbUt5YkRwckZBN1l0Z1hIWjZLRlB2MXVoQ3ZqUFJXYzQ1RVlaSlNLdEdvZVBOcVQxUE1janhhQVhWTEhHQy1IWWhTbG9QY3JEbm02SlRiSU9YbV8za3J2bDJhLTdkRG50M2R1X25UUkh2WUc5UFp3NFJqaGRWdzZSVFRhNTJXV2NLUHRXd01QM3VJM1lZdXE2YWhGUEh3?oc=5" target="_blank">3D map reveals DNA organization within human retina cells</a>  <font color="#6f6f6f">National Institutes of Health (NIH) | (.gov)</font>

Klf5 -adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity
Natureworld

Klf5 -adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE80MmhEdjQzaV8xU05zb2hKU29uRFBfVklHQzhSR3Q0OVRRQTJZa1lGWWVhc1pmWXBzT0FUMWx5Zkh4b0hKM2laVEotdVFIbWdZVDBEcFJ4MTBEWnVFU2tZ?oc=5" target="_blank">Klf5 -adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity</a>  <font color="#6f6f6f">Nature</font>

High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci
Natureworld

High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9Ea1V3bXpqcUNzMmFoSUtGajR4dkJPaDFPMTBFcll6REhLSWcwLWRGNHktdjZ5TjE3LS01aDhOQWZnckJmNXZaZHJCRFZmbXVJUjZVaFZCOFF0a2kzeVdV?oc=5" target="_blank">High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci</a>  <font color="#6f6f6f">Nature</font>

Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs
Naturegeneral

Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1SczJaOTd3Z0lXRW5lLURlNWIyTVhPcWRzWkhUM3RZR3FSeWhqa09QWnpjYktPUjBTSHJjREZXTXNoMWVPb2xYWXB0cGpoM2FWbGkyTTFMRHVhZlRRbXRJ?oc=5" target="_blank">Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs</a>  <font color="#6f6f6f">Nature</font>

Super Enhancer RNAs Rewrite the Molecular Script of Complex Gene Regulation in the MDD Brain
Naturetech

Super Enhancer RNAs Rewrite the Molecular Script of Complex Gene Regulation in the MDD Brain

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE10amZ3Rl9sa2hpSVE2c0dUWXMwQUE4MzIxWFRqWU0tcURzQ3ZfNGhrWVppa09hd3R3bElRWHBkc1hBVklGNTliYjRhdEEtVWEteGpLM29VUnJaLUEyRVVB?oc=5" target="_blank">Super Enhancer RNAs Rewrite the Molecular Script of Complex Gene Regulation in the MDD Brain</a>  <font color="#6f6f6f">Nature</font>

Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity
Natureworld

Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9hMThqRGd1SzZFMkEtaDkxZ0pXUkJRTWNjRk9teHEtZEc2R2VWaklxQkxRVXVzTHNhTnlqZnBNeTQyNW5pNENtVUh6OXEwUXRId2tONnNIWXRweXFhQ2Q0?oc=5" target="_blank">Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity</a>  <font color="#6f6f6f">Nature</font>

Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma
Naturegeneral

Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBtbWtBT2pCSlAxendFbExhVEJvUEpCN3FfTGY1U1ZhaFlUQ0V3YWRFVE15VDNXNWE4UE5rdE91dERXLVdHYWFDclZtQ3BwMmtLdVBJS281R3lpbnBnZ2dN?oc=5" target="_blank">Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma</a>  <font color="#6f6f6f">Nature</font>

A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest
Natureworld

A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9UZWxEeTlza0xBWHEzUU04ZF9YWTl4TThjcGo5U29Kemc1NXVuRjd0X0x0MFRuWjA0aktaWmFqSFd4dlNybk9tc1Buc0xTQW5PRXE1d1I2X2xLSTcwY1Fr?oc=5" target="_blank">A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest</a>  <font color="#6f6f6f">Nature</font>

3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression
Naturegeneral

3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFA0Mld1TWp5cXdSMVZ5dmQ0cVNDUTc0dGhGcmhtWjU1ZXZHNVZFVXZFUWdULU1KdFFOMlBxS3hPdDRjQkNaT0JMZ3Rsb2FSTkR5bV95NVR6d2pabVBzQkU4?oc=5" target="_blank">3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression</a>  <font color="#6f6f6f">Nature</font>

Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks
Naturegeneral

Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5TakdST3dBNVhFbGZjM0J1ZzNJSHRXRFBFMW5iQUQ5VzI2YnA0b1BwcV9LX2pYOTBqUEcwcFB0eWVxNU5aMVM3QklJSFVzcFZRcTYtU0V0S0ZDbW9xdVZn?oc=5" target="_blank">Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks</a>  <font color="#6f6f6f">Nature</font>

Epigenomic and 3D genomic mapping reveals developmental dynamics and subgenomic asymmetry of transcriptional regulatory architecture in allotetraploid cotton
Naturegeneral

Epigenomic and 3D genomic mapping reveals developmental dynamics and subgenomic asymmetry of transcriptional regulatory architecture in allotetraploid cotton

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9DdzhGcUVsQ0N2X19pRTB1ZVJDSlNmQ1RYczJ0TlAwa29UM3dxZllKckplbmZmVWhZUXV2bUJneUxVU2JqQVFPbGZPeVlNVGNBc2U4Y0NrUWxwTzNzM1FJ?oc=5" target="_blank">Epigenomic and 3D genomic mapping reveals developmental dynamics and subgenomic asymmetry of transcriptional regulatory architecture in allotetraploid cotton</a>  <font color="#6f6f6f">Nature</font>

Divergent combinations of enhancers encode spatial gene expression
Naturegeneral

Divergent combinations of enhancers encode spatial gene expression

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE0yRVZTZE41MXdZQ3I0TF9fZWJ1MUEyWW8yZDdGNFIxTUZISU00ZHBFUXoxR2VybFJTU1dNUnNhZnBVSm9ZOUJZMl9ZeTN0WmN3M2x2UktVajRFM3FPTkNV?oc=5" target="_blank">Divergent combinations of enhancers encode spatial gene expression</a>  <font color="#6f6f6f">Nature</font>

Connectome and regulatory hubs of CAGE highly active enhancers
Naturegeneral

Connectome and regulatory hubs of CAGE highly active enhancers

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9aSFlnb0lwZlJ3eHpUZDRXc1NlbklmZWJpMng3MXlnVmhsSkJKTkF5bm1KQWdDYXhZR21QbVVxclIxWEpsVnNGVUgyVzNWWTdwSjYwN2VJSE1pWVlwMnBF?oc=5" target="_blank">Connectome and regulatory hubs of CAGE highly active enhancers</a>  <font color="#6f6f6f">Nature</font>

Chromatin interaction networks revealed unique connectivity patterns of broad H3K4me3 domains and super enhancers in 3D chromatin
Naturetech

Chromatin interaction networks revealed unique connectivity patterns of broad H3K4me3 domains and super enhancers in 3D chromatin

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBtTmJKQ2hUMjZDQnNuWWF4MXdEZDhlcXgxdUpGaGNvUk9tQTFlWUFBSV84NWtVMnpLYUxEeWpMcUpSVWd1V0t3S0YtWG8zLTQ3RkNFTUYwMmdHckRjZFo0?oc=5" target="_blank">Chromatin interaction networks revealed unique connectivity patterns of broad H3K4me3 domains and super enhancers in 3D chromatin</a>  <font color="#6f6f6f">Nature</font>

Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression
Naturegeneral

Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5FVEZzUUVmTDA5Zmp4c21qSTJFVy15WElmQ1FnbTBMMmo4NE9qd09ibWJ5OHFPUHVYYWZ4blZnUHRub1EzR093cm9hSTFOYmo2QklVclJfNXJ4SWpZVXdn?oc=5" target="_blank">Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression</a>  <font color="#6f6f6f">Nature</font>

Mapping nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL
Naturegeneral

Mapping nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBrY2lkTzRRbjZ1VTQ2MzRLNXZwVnhUdTAzcFlWcDZCZzg5eXpsc1R6Wm9rTDJtVlZxRjR1Q1ZvMC1wQ1E2Z0Nxemd5emI3VktlbzcybDhzbDBXNlpoeEtv?oc=5" target="_blank">Mapping nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL</a>  <font color="#6f6f6f">Nature</font>

Dissecting super-enhancer hierarchy based on chromatin interactions
Naturegeneral

Dissecting super-enhancer hierarchy based on chromatin interactions

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE82WXRtQ0dpQU1vVkQyekltNG9FckFvQmhWUnk3M3lXUFo2ZUg5M1h4dlJ3bl83WVc1VUpMeHF1TmJCWWR3NmdON0MzM2ptM2N0MXRlT2kzZEJiS3B5YXlN?oc=5" target="_blank">Dissecting super-enhancer hierarchy based on chromatin interactions</a>  <font color="#6f6f6f">Nature</font>

The 3D enhancer network of the developing T cell genome is shaped by SATB1
Naturegeneral

The 3D enhancer network of the developing T cell genome is shaped by SATB1

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE92RjVyQzNpS2xZNF9hcmhlUFo1aW52V0NjZG8yVlBxclF1S0Uta1REejdKeWFOYjhfcEVFaE93M05NUk94MDdzZzBub0E0VE5zS2dZbjBMOG92Q0dtX0hR?oc=5" target="_blank">The 3D enhancer network of the developing T cell genome is shaped by SATB1</a>  <font color="#6f6f6f">Nature</font>

ChIATAC is an efficient strategy for multi-omics mapping of 3D epigenomes from low-cell inputs
Naturegeneral

ChIATAC is an efficient strategy for multi-omics mapping of 3D epigenomes from low-cell inputs

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1aVk9DdDZvZ1N1RzNjY19NTGhVb0lJdS1fYndEekc3U2Rhb0g2MWRDTmx3Z3dhYlR2VHZmblRtbVBnU2NjTWlicXN0Ym9INzhmc2VNNkxUQjZabEhSV3Y4?oc=5" target="_blank">ChIATAC is an efficient strategy for multi-omics mapping of 3D epigenomes from low-cell inputs</a>  <font color="#6f6f6f">Nature</font>

Oncogenic transcription factors instruct promoter-enhancer hubs in individual triple negative breast cancer cells
Science | AAASgeneral

Oncogenic transcription factors instruct promoter-enhancer hubs in individual triple negative breast cancer cells

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1VMTlEbXdIR3Btd3NVQ1dPZEV4dWRXSVhHQnFfQ0NfY21KUVVYVEY0WFcyVUNZM29jMldLYVBqVTB0cS1NQkk5eHpEdEljOUlBaG9WUjVkeTZhbnlnellv?oc=5" target="_blank">Oncogenic transcription factors instruct promoter-enhancer hubs in individual triple negative breast cancer cells</a>  <font color="#6f6f6f">Science | AAAS</font>

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association
Science | AAAStech

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

<a href="https://news.google.com/rss/articles/CBMiYEFVX3lxTE9xT0xFWmZUUThRdGtvZ2ZZMVVpOTh6RVhGNGNRY3puZTRiZEFuOWhQaDJTcXVveFJRSklxUFlMV0hJWXlIakx1Y1VicDdyQ2w1dzBlZlBaRW5lVkduZTVZVg?oc=5" target="_blank">Brain cell type–specific enhancer–promoter interactome maps and disease-risk association</a>  <font color="#6f6f6f">Science | AAAS</font>

A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer
Naturegeneral

A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5NVTZ2eXg5dTRLZUxSemxTZWdFOUZ2TWFjZEVOak92emNxSzNIMnd0NUJ6QjhZZmZfc3l3ZW4yVDB6S2E0ZnA0N2EyRmFXSy0zUEsxNG91RmRmYWliMDFz?oc=5" target="_blank">A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer</a>  <font color="#6f6f6f">Nature</font>

Constructing 3D interaction maps from 1D epigenomes
Naturegeneral

Constructing 3D interaction maps from 1D epigenomes

<a href="https://news.google.com/rss/articles/CBMiVkFVX3lxTE9WYVBlNlpNdExsNUd6ZHRJUEt2VFpQZHlQclBVR2k5ZHdzbkZEcDBFVFcxRFprS0ROTmNSUUxSaG1sRGViSFRNV1d0OF9hbUhMREZQd3pR?oc=5" target="_blank">Constructing 3D interaction maps from 1D epigenomes</a>  <font color="#6f6f6f">Nature</font>

Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation
Naturegeneral

Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9udU5UckQ0bFg4R0xpMUlyb2dpcjdRNlRDaVZBNzJxVENaTDlLMUthY216R0tCN3NGWll0ekxncEUzRFotNFB4MmZiajlYcHZnZk9YWC1lc1o2Z0FvY0Vv?oc=5" target="_blank">Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation</a>  <font color="#6f6f6f">Nature</font>

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration
Naturegeneral

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1HVUlFSTRvWDVraVNtdHVTN1NSekppdFFYVk9ETkhPYmZfRHVhZ3NIN1FKdGhsUHAzQnh5eEtPUS0ycExwcmpjVkR0VkU0ZUlpMkZwNnppY0taTDR3XzZR?oc=5" target="_blank">Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration</a>  <font color="#6f6f6f">Nature</font>

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1
Naturetech

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFA2M3V3emhMY01HUDBvNzZ4ZE8xT19JZnc3WkxUdHU2RTlPN3NBTVFEdEZWajc4ZEpxRFMtSUN4NjhiUnlCcmVDdVdJZ2FwazJRWS0tYmhtWHRmUU45cGdF?oc=5" target="_blank">Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1</a>  <font color="#6f6f6f">Nature</font>

"Mapping 3D-super-enhancer" — Live Google News Trends & Headlines