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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Large-Scale Conformationa" (30 stories)

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Efficient sampling of large-scale transition pathways and intermediate conformations in sub-mesoscopic protein complexes
Lead StoryNaturegeneral
Mar 2

Efficient sampling of large-scale transition pathways and intermediate conformations in sub-mesoscopic protein complexes

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFB2TGt5cERFWXBzOEptc0VpcXpkQmh4UkpSTGNXSHItM0VvcUQwSmlwNmlzbGZjSm8zMDVqaGVqcER1Q2VpOHVLeEdiazVJNWhzbHk2NExqOGNDUWxfbjZn?oc=5" target="_blank">Efficient sampling of large-scale transition pathways and intermediate conformations in sub-mesoscopic protein complexes</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "Large-Scale Conformationa"

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29 stories displayed
Large-scale discovery, analysis and design of protein energy landscapes
Naturegeneral

Large-scale discovery, analysis and design of protein energy landscapes

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBwanFYbGtac1RUOWVya3RMamhxamJzYkQwdDZKc25GSnJKYkt5VVNWNkpzQU12eDFKTzJRbFNieUo2V2VqcThJLUMzWU1OR0hOUjJsc1dCci15dXZlSHBJ?oc=5" target="_blank">Large-scale discovery, analysis and design of protein energy landscapes</a>  <font color="#6f6f6f">Nature</font>

Large-Scale Conformational Changes and Protein Function: Breaking the in silico Barrier
Frontiersworld

Large-Scale Conformational Changes and Protein Function: Breaking the in silico Barrier

<a href="https://news.google.com/rss/articles/CBMingFBVV95cUxPQUdmMTRCX091alZITXRLLTZxUmdWUnJDU244ZGI2M0RaMFdEMlhRSHpBeGktUThMS0ZLcHdvYVFGR3FmQ0EzT0hPU25Qd2hSWU44RGwzZGRITU9mc0VTZ25LUGhhenVjSE1OckNNd3Z0a3VnY3QwNEdiQXdaNFUybnF6V3BSY3ByTDF0UDdqN2RRNHdlWEhfVVVwaUVmZw?oc=5" target="_blank">Large-Scale Conformational Changes and Protein Function: Breaking the in silico Barrier</a>  <font color="#6f6f6f">Frontiers</font>

Exploring Protein Conformational Changes Using a Large-Scale Biophysical Sampling Augmented Deep Learning Strategy
Wiley & Sonsgeneral

Exploring Protein Conformational Changes Using a Large-Scale Biophysical Sampling Augmented Deep Learning Strategy

<a href="https://news.google.com/rss/articles/CBMidkFVX3lxTE9ubXJkM0R4UVVuMGdzZzE2ZXhXMnl4YlVKQ3hhbUFBUUhvR3N1LWdWbm5WOFFfWmg1dS16XzMxUzJMYTVYRmg5dmdRY19jZmkyYWUySGVSTTFNRTk0VFZJNDk3Z2ctVGd3WkJRRkxJMW5tcXRWcGc?oc=5" target="_blank">Exploring Protein Conformational Changes Using a Large-Scale Biophysical Sampling Augmented Deep Learning Strategy</a>  <font color="#6f6f6f">Wiley & Sons</font>

New Experimental Method Reveals Protein Energy Landscapes on Larger Scale
Northwestern Universitygeneral

New Experimental Method Reveals Protein Energy Landscapes on Larger Scale

<a href="https://news.google.com/rss/articles/CBMiwgFBVV95cUxNMnh1c0dmMTM0V3lPWV9zWjlhX0Y2dEdLTTdRbDBTYTVKcjRJN19MYnJJQWtmaWRTdDBpMm9kRzVvZWxRYWgzX0tkNG9lWnNKckVKYkZ2RkwtTnpvQXl3TkRJWFZnamt1TktkSVVheHNUMERFVjI2VGdPcERoOGhVYWNmbmliejY0LTZKSWQ3XzZVajRVOHNXWnp4RmhuUnJYLUVpQWZDT3d1bzVvRWp6THJHdzZHUWQxakVzMHU3WWVOdw?oc=5" target="_blank">New Experimental Method Reveals Protein Energy Landscapes on Larger Scale</a>  <font color="#6f6f6f">Northwestern University</font>

Computation of conformational transitions in proteins by virtual atom molecular mechanics as validated in application to adenylate kinase
PNASgeneral

Computation of conformational transitions in proteins by virtual atom molecular mechanics as validated in application to adenylate kinase

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE1BclpZbFRvekRFSXhpMW1nU0QxZDRnN1g4QW9mZnFaNTh6aDM1MkhvQ3VMdmNTT0I3aTJGX2tFSFZsV0VyNkZkVkxYYnlLb1poUU9vWjI2SDVycGpU?oc=5" target="_blank">Computation of conformational transitions in proteins by virtual atom molecular mechanics as validated in application to adenylate kinase</a>  <font color="#6f6f6f">PNAS</font>

Challenging AlphaFold in predicting proteins with large-scale allosteric transitions | Communications Chemistry
Natureworld

Challenging AlphaFold in predicting proteins with large-scale allosteric transitions | Communications Chemistry

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5Va2l2eHhUUi1pRzJKY0pINzI0NWppV3ZwN0tZOFBKSG9GWXF5NEZRQ2cxc1V0ME45Ujg2aDQzeXIwQTEteXFxWjdGckRiV2Z1X0RlUWsyTW41aUJ4Skpn?oc=5" target="_blank">Challenging AlphaFold in predicting proteins with large-scale allosteric transitions | Communications Chemistry</a>  <font color="#6f6f6f">Nature</font>

Illuminating the mechanistic roles of enzyme conformational dynamics
PNASgeneral

Illuminating the mechanistic roles of enzyme conformational dynamics

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE5JeEF0UHJoLVc2YmVwZ1oxbWdsdmowbnpwZW10VFJHNmNUYlJwLXVHZHV3QjdQU0xlMmZXdG1ZcWlJTGR4ZkliOFdmWUQwUm1XNjQtZHE1UHRYREVp?oc=5" target="_blank">Illuminating the mechanistic roles of enzyme conformational dynamics</a>  <font color="#6f6f6f">PNAS</font>

Large-scale predictions of alternative protein conformations by AlphaFold2-based sequence association
Naturegeneral

Large-scale predictions of alternative protein conformations by AlphaFold2-based sequence association

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1hV19yM3czWXpCNl96NU10U2hTYlMxVjFhRFRaLW9iQi1pcG5LVDU0WnV2QUtaaGJMaDF5VHdUQmNSVkxZNlRVNmtCekhUS2Y5VDdNVzBkYWxUTmh2RTJR?oc=5" target="_blank">Large-scale predictions of alternative protein conformations by AlphaFold2-based sequence association</a>  <font color="#6f6f6f">Nature</font>

Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism
PNASgeneral

Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE1WajZwY2VHSzZsaXVLaVY3bFQxTG1HTm5lYjczWF9Gc2xoT0ZNcnBIZDczWnlVZzFmSGE1M0lZUDdxZ2xsVVRFREhKaDBrUzZJSDZNQ2tRRG9jOERS?oc=5" target="_blank">Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism</a>  <font color="#6f6f6f">PNAS</font>

Protein-peptide molecular docking with large-scale conformational changes: the p53-MDM2 interaction
Naturegeneral

Protein-peptide molecular docking with large-scale conformational changes: the p53-MDM2 interaction

<a href="https://news.google.com/rss/articles/CBMiU0FVX3lxTE9Va3pJbWJ6eTBZRkZTdDhid0JMaFJHUTBlZFpDTmdQX0RiS09SNUMtMUxCOFhteGc2YzBJUlZILW9rbThRbXRVVlFLd2pTVnlQalhN?oc=5" target="_blank">Protein-peptide molecular docking with large-scale conformational changes: the p53-MDM2 interaction</a>  <font color="#6f6f6f">Nature</font>

A self-conformation-aware pre-training framework for molecular property prediction with substructure interpretability
Naturetech

A self-conformation-aware pre-training framework for molecular property prediction with substructure interpretability

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE12OEl6UFVfWEhZVURPNlF5TEZFQ0V4MTFRTVhqTjF3dGU4NTVQVy00U3IzWXROTFBtaWs2QlRwMlhDTThxN0lZeFVLLW5qVjMtRFQxNUpmUjFZcC1oa2hF?oc=5" target="_blank">A self-conformation-aware pre-training framework for molecular property prediction with substructure interpretability</a>  <font color="#6f6f6f">Nature</font>

Disentangling coevolutionary constraints for modeling protein conformational heterogeneity
Naturetech

Disentangling coevolutionary constraints for modeling protein conformational heterogeneity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9sSGViM0FPVnlrVF9ldnRHeTBLWkF1S0ljeDh6N3lHVEg0TVBwNk5Kdl9ZMzBmQ2FBMlhSd19HUTU5dmhkN0s5eG9HMXFZWU5FSmhHcU13dzZXNW5uM2xn?oc=5" target="_blank">Disentangling coevolutionary constraints for modeling protein conformational heterogeneity</a>  <font color="#6f6f6f">Nature</font>

Exploring the conformational landscape of adenylate kinase and beyond with protein folding models
Naturegeneral

Exploring the conformational landscape of adenylate kinase and beyond with protein folding models

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBnU1ZrTGcwQVN0b3c3UGo3RGNQbzZKRWFjdkpaRVkxcnowcVlwRjg3bkxjcEVaQVBOVHFrY2MtQTg1cTNCTi1EVVJYZGg0MXRrLWNrWkg5aDN5X1JOaEh3?oc=5" target="_blank">Exploring the conformational landscape of adenylate kinase and beyond with protein folding models</a>  <font color="#6f6f6f">Nature</font>

Direct prediction of intrinsically disordered protein conformational properties from sequence
Naturegeneral

Direct prediction of intrinsically disordered protein conformational properties from sequence

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5zU0NUbkJGU1VpeE5OV1ppZVhwX0NZSS1VVm9oUmdpYWFuV2s1MlJsZEViVnhlU1RobnR6VEg3ak9acHJfOEExMkJnOWp2aGVKb2VLdUkwbFk4QU1HU0w0?oc=5" target="_blank">Direct prediction of intrinsically disordered protein conformational properties from sequence</a>  <font color="#6f6f6f">Nature</font>

Enhanced sampling of protein conformational changes via true reaction coordinates from energy relaxation
Naturegeneral

Enhanced sampling of protein conformational changes via true reaction coordinates from energy relaxation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9sZWdMUWQxSUVrRW8yZ0xqc01NaUlfRUhWS3d4bjFqNVRkM3hGbkM1RGNPWGpONTk1bGlNT003Q1FFVWhxWkc0WDVaSzJqMmlVVWFTT1BrLU52Q3pWYUdZ?oc=5" target="_blank">Enhanced sampling of protein conformational changes via true reaction coordinates from energy relaxation</a>  <font color="#6f6f6f">Nature</font>

Stable de novo protein design via joint conformational landscape and sequence optimization
Naturegeneral

Stable de novo protein design via joint conformational landscape and sequence optimization

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5OWWw2dS1vSnlFU2NOSXh2M291amwwYmhFbVBjSk5MdjlmOHJHQTM0MWZIT25FSVlsYjhjS2Jhc1dfLXJCa3dXVkxRRThaVzZ2R3JBQkJLclFHTVdGNG1v?oc=5" target="_blank">Stable de novo protein design via joint conformational landscape and sequence optimization</a>  <font color="#6f6f6f">Nature</font>

Communication pathways bridge local and global conformations in an IgG4 antibody
Natureworld

Communication pathways bridge local and global conformations in an IgG4 antibody

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBjSjdyZWVHalJKWWxJX0xQQXhNX1J3R2pRaHpqd3FBOTVGTHNZYm1ma0N2YnlBc2dSZFhHQTR1bU1nRERuOXhvaGlrcGh3UGhTQ29sc0JfWXV2T1pvWDg0?oc=5" target="_blank">Communication pathways bridge local and global conformations in an IgG4 antibody</a>  <font color="#6f6f6f">Nature</font>

GōMartini 3: From large conformational changes in proteins to environmental bias corrections
Naturegeneral

GōMartini 3: From large conformational changes in proteins to environmental bias corrections

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBvV0VRaUVWc1B1RHdiWmkwZGRLSjRPekJ0ZzlDMDQ2V25OTWdxWmx4MS1xV2NTRFB5aG5DbHJsWTFRNVQtNU9fb2NTQXVjQlNiZ1J6WUVtZW12eGFJdzJR?oc=5" target="_blank">GōMartini 3: From large conformational changes in proteins to environmental bias corrections</a>  <font color="#6f6f6f">Nature</font>

Structural mechanism of a drug-binding process involving a large conformational change of the protein target
Naturegeneral

Structural mechanism of a drug-binding process involving a large conformational change of the protein target

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9hQVVJb0Zyc3p3VnhmSzI2OW9Mdi00V00tVWUyMVRfRFJvcUdKZ2JDRWc1aGduWjE4VndXa0ZRRlFMT2UyVVlxWkxKZHFIa251a1JxWmJ6R0VEOWpQZVkw?oc=5" target="_blank">Structural mechanism of a drug-binding process involving a large conformational change of the protein target</a>  <font color="#6f6f6f">Nature</font>

A conformational benchmark for optical property prediction with solvent-aware graph neural networks
Naturegeneral

A conformational benchmark for optical property prediction with solvent-aware graph neural networks

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9yVlUtYlR6UWNzVnRDQWR1U0lqdkl0NVFoQlhja1lpYXNLc21RaC05Q2N2anVfcnBSTmlyYVd2aE80ajVfbUVFY21LWnFwelhiWWhBeGRGSWJxY0F0Q293?oc=5" target="_blank">A conformational benchmark for optical property prediction with solvent-aware graph neural networks</a>  <font color="#6f6f6f">Nature</font>

Deciphering conformational dynamics in AFM data using fast nonlinear NMA and FFT-based search with AFMFit
Naturegeneral

Deciphering conformational dynamics in AFM data using fast nonlinear NMA and FFT-based search with AFMFit

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5CM3YwdUxzc0VlV195alVnMWdSRmdiSWdWYldCaF92SHFYYWJpWWNiVC1UNnJoWkNIYUU4Tk5SYW4zbm5iTWVhYTJ4NGI3b083aUQtNGRQVXZOMkF5RnE0?oc=5" target="_blank">Deciphering conformational dynamics in AFM data using fast nonlinear NMA and FFT-based search with AFMFit</a>  <font color="#6f6f6f">Nature</font>

Structures of the P. aeruginosa FleQ-FleN master regulators reveal large-scale conformational switching in motility and biofilm control
PNASgeneral

Structures of the P. aeruginosa FleQ-FleN master regulators reveal large-scale conformational switching in motility and biofilm control

<a href="https://news.google.com/rss/articles/CBMiYkFVX3lxTE1GS3d1NXJUUVF4UVJQNllUN2VfWGY3MlFRWFRHeGRiMmhzRDhneEU4OFdSemEwb0pRQldSdkg4Z0l0b0tfTmdaSnBwcEpGdWZUYUFwc0FXT2szM1ZfWkNsUVB3?oc=5" target="_blank">Structures of the P. aeruginosa FleQ-FleN master regulators reveal large-scale conformational switching in motility and biofilm control</a>  <font color="#6f6f6f">PNAS</font>

Millisecond time scale conformational flexibility in a hyperthermophile protein at ambient temperature
PNASgeneral

Millisecond time scale conformational flexibility in a hyperthermophile protein at ambient temperature

<a href="https://news.google.com/rss/articles/CBMiW0FVX3lxTE5pUWUxYUZEd19YNkVSd24wd1lQMXVKbnRPRlFGTXpzVGNLMnBnNkRRa2MwZjM2S0hRLVJpVHB0cng4TkMwSEc1TFVmQVp5RzhHczJxa0NGQ0ZlX0E?oc=5" target="_blank">Millisecond time scale conformational flexibility in a hyperthermophile protein at ambient temperature</a>  <font color="#6f6f6f">PNAS</font>

Large-scale conformational changes and redistribution of surface negative charge upon sugar binding dictate the fidelity of phosphorylation in Vibrio cholerae fructokinase
Naturegeneral

Large-scale conformational changes and redistribution of surface negative charge upon sugar binding dictate the fidelity of phosphorylation in Vibrio cholerae fructokinase

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5qc1AyZXlDMXBOc3BfTUduYmZlSHNoc2trQ1NfcDBRLXpZQnRGcTNwVlNBY3RHRElnWW9saHdYLVpNZWZLTy1fOU5YRGtBY3dOUFJJaS1fcDRpYlJJcjlr?oc=5" target="_blank">Large-scale conformational changes and redistribution of surface negative charge upon sugar binding dictate the fidelity of phosphorylation in Vibrio cholerae fructokinase</a>  <font color="#6f6f6f">Nature</font>

Chemical functionalities govern polyamide–alumina adhesion through local conformational dynamics
Natureworld

Chemical functionalities govern polyamide–alumina adhesion through local conformational dynamics

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9LR3JYQnhUTHg0NXNqS1gwZ1RYdVVOUGNvR21ncXJrVENic3pXSTBteFNDSGJTUGh2SXN2S2JxWVhRMnRna21uVkNGY01wTW5ZVkpwQklteVQ3czk5dGhn?oc=5" target="_blank">Chemical functionalities govern polyamide–alumina adhesion through local conformational dynamics</a>  <font color="#6f6f6f">Nature</font>

Data-driven quantum chemical property prediction leveraging 3D conformations with Uni-Mol+
Natureworld

Data-driven quantum chemical property prediction leveraging 3D conformations with Uni-Mol+

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE0wbDVPZldRQXNCRWVJenZYVnM3SThNRFloM24xMXMwMXM5eGQyVEJzaTdId3VISWIyODVNVXlscjVqQll1NG1uOV9HVVRST3RUSDRLaUdBb1dma1IySlIw?oc=5" target="_blank">Data-driven quantum chemical property prediction leveraging 3D conformations with Uni-Mol+</a>  <font color="#6f6f6f">Nature</font>

Continuous millisecond conformational cycle of a DEAH box helicase reveals control of domain motions by atomic-scale transitions
Naturetech

Continuous millisecond conformational cycle of a DEAH box helicase reveals control of domain motions by atomic-scale transitions

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE8tQnMwb0poUDVSeEpBQzNaV2dDN19QYjBTekxRenRMU25MVmVFVUJza0xjMWt5WEpHOXJUVUd3Q1ZFMEtxd1JHRGxUQkNPVTVzTERfRlpVMWVTSk9GdzJz?oc=5" target="_blank">Continuous millisecond conformational cycle of a DEAH box helicase reveals control of domain motions by atomic-scale transitions</a>  <font color="#6f6f6f">Nature</font>

Characterizing conformational states in GPCR structures using machine learning
Naturegeneral

Characterizing conformational states in GPCR structures using machine learning

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE81LWxidkdVQV9CZVBscjBVWEc3dEhHWFluWmZEN1YyaWdHQ3BraXBFWW4ySmtnalRteUhHNVp4N2tIWFk2YmZ5VHgxNlZxTE9COExPSW94VUdZbk0yRV9F?oc=5" target="_blank">Characterizing conformational states in GPCR structures using machine learning</a>  <font color="#6f6f6f">Nature</font>

Energetics and Structural Characterization of the large-scale Functional Motion of Adenylate Kinase
Natureworld

Energetics and Structural Characterization of the large-scale Functional Motion of Adenylate Kinase

<a href="https://news.google.com/rss/articles/CBMiU0FVX3lxTE1WTFN1cUVQYkxnRnNleUZLajRhbnlCNHUwbDVfSWlBZUZNaEQyejRlSmZDUVNMczgzR2dzSXBTMU1pMHlvLXpTQWxHOFAtdWNwdmpn?oc=5" target="_blank">Energetics and Structural Characterization of the large-scale Functional Motion of Adenylate Kinase</a>  <font color="#6f6f6f">Nature</font>

"Large-Scale Conformationa" — Live Google News Trends & Headlines