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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Kupffer cell programming" (30 stories)

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Kupffer cell programming by maternal obesity triggers fatty liver disease
Lead StoryNaturegeneral
Jun 18, 2025

Kupffer cell programming by maternal obesity triggers fatty liver disease

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE44WGV6N0pyYnFFS2NQeEotTF9IY29jRXVtSlBfVTBFVE1ZcktfNmMzV2RxV2lUNzNTNGhOQ24wd25QTFd4cE9MZlA3RFltaTZXV29FTEY4WUVzWjV5Ykhz?oc=5" target="_blank">Kupffer cell programming by maternal obesity triggers fatty liver disease</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "Kupffer cell programming"

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29 stories displayed
Bile Acid Sensor FXR Drives Liver Regeneration by Rebuilding Its Immune Cell Army
Bioengineer.orgworld

Bile Acid Sensor FXR Drives Liver Regeneration by Rebuilding Its Immune Cell Army

<a href="https://news.google.com/rss/articles/CBMiqgFBVV95cUxQdVBzTnRaQTVQQXRDY0hQM2dENHIxdl9TTGt0V1pQamJhU3owVTU0S2pDdDhOSmVzRUtGSkJveUcwTmpHSWREX2F2OFowZUphbk41UXo1ekZvXzRtVHRRcVF3NktDQkUwWnNyNmNndXB3bjVaZFNnMkxnQ25pU0tPTURpUmZ3TmVvVHJ3SGxzaFRyZkxaN3RDY1dfbHBIa0hzVUkwaFRGYTcxdw?oc=5" target="_blank">Bile Acid Sensor FXR Drives Liver Regeneration by Rebuilding Its Immune Cell Army</a>  <font color="#6f6f6f">Bioengineer.org</font>

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Targeting macrophages in liver fibrosis
Frontiersgeneral

Targeting macrophages in liver fibrosis

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxPQkV3MGU2NzdqVlEzY2RMdmZkQWF6NjNfZERJZmVSNE9aRFVpTjZ6TG9lbFRNWW1YaElzdjFiRUdUSEFBcEROdkdpaTdKY0tOdjY2VVhZWGZFTU9iUEYtc0liaWoxNUlDV0dDbVRhU0F3QzBpZXU4VXpLa21aVWNpcjEwWWQ1VkQwSnFnVTZONUF4dw?oc=5" target="_blank">Targeting macrophages in liver fibrosis</a>  <font color="#6f6f6f">Frontiers</font>

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SLC38A4 promotes Kupffer cell phagocytosis and suppresses tumor liver metastasis
Naturegeneral

SLC38A4 promotes Kupffer cell phagocytosis and suppresses tumor liver metastasis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBCSTFLZW5vNHF0Sm1kSjRRNGYzenVva01OQTJqOFlEZ2M0amtHOVJQbzM1bjE2aEd0TFpxYmlZVnZESFQ4amdLRXZzUGdxSWdTMUdBZG5BaEtJaDRyNk9n?oc=5" target="_blank">SLC38A4 promotes Kupffer cell phagocytosis and suppresses tumor liver metastasis</a>  <font color="#6f6f6f">Nature</font>

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Targeting macrophage metabolism: mechanisms, cellular crosstalk and implications in obesity-associated metabolic diseases
Frontiersgeneral

Targeting macrophage metabolism: mechanisms, cellular crosstalk and implications in obesity-associated metabolic diseases

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxNZUdlM1FuNmFpRnhXOURxYmRoTXNHdEhVMERLS3dHTG1UNnBVeEtoN3dlRklDNTlQb2c5My1ja3pBc1Y3ZXM2cFZpcW1jWXdjclJEa3ZzREVjR3NvX2pQYzloanhEXy1HMmRjX2MxYkZIVzVnVklXVHZpY1EtUndVcFV0NTZrbGk1UDRQaVNQX0VsZw?oc=5" target="_blank">Targeting macrophage metabolism: mechanisms, cellular crosstalk and implications in obesity-associated metabolic diseases</a>  <font color="#6f6f6f">Frontiers</font>

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HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis
Science | AAASgeneral

HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis

<a href="https://news.google.com/rss/articles/CBMiZ0FVX3lxTE05aE1TMHU0c21PUEtFQUsxck84S25vSFRqM0JMa1BFZTFrN1ctX2d4dHhXSW1ZUHZvWjJvTVJfc0FnQWYyMlBrakhZREwyTzlId2tELTljSm83SzFHYzJhMnY4T3BwNUk?oc=5" target="_blank">HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis</a>  <font color="#6f6f6f">Science | AAAS</font>

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Kupffer cell reprogramming in embryos explains metabolic disorders in offspring
News-Medicaltech

Kupffer cell reprogramming in embryos explains metabolic disorders in offspring

<a href="https://news.google.com/rss/articles/CBMixgFBVV95cUxOd3pRUlhGZzRrTHFqNWtVVjE1Q2E5R25uTkpqMDVsSEFOT2ZBS0tXNy1PcWE3M1UtVXFrVzVrRVNqdEpVcEhZeW5XVTZDRmdIM0cxMW16bEpMRWVMNDMzNFE3X3lnUTNXR1lXa1lxUklGc19TNjR1SXE1VFBXcm5hWkhVdVMxalBXRW1HR3VOV3lzeXN3ek9PNmhTNTJSaC12TXJaVVpGbTRYckpuYjU5aENxOEF2SW5RTVZQeXpkakF0U0hlTFE?oc=5" target="_blank">Kupffer cell reprogramming in embryos explains metabolic disorders in offspring</a>  <font color="#6f6f6f">News-Medical</font>

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LINC02709 drives liver cancer spread by boosting stemness and suppressing Kupffer phagocytosis
Bioengineer.orggeneral

LINC02709 drives liver cancer spread by boosting stemness and suppressing Kupffer phagocytosis

<a href="https://news.google.com/rss/articles/CBMiuwFBVV95cUxOTjR6RUFvTHNyU1Y5cXB3Y0lKRDRFRUpVdGRHN0RCdU50RktsYmsySG9LbEFzdTRrYzJwNDQ1T2JrWGpGYWV1OWswUW4wVXhBV2w1THFqanA2OHJPcHAtdnJNWXMyc2hSVnRCLXptUDFFc2M4UHR3cEt0S1Baa2lOLVI0S3o2QUd1M1FweHNuNU5wNUtUWHltek5zdlNDTEhlRWgtWE92MDk0Qkp3REZ5VDlkcl9DbTBfOTZn?oc=5" target="_blank">LINC02709 drives liver cancer spread by boosting stemness and suppressing Kupffer phagocytosis</a>  <font color="#6f6f6f">Bioengineer.org</font>

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Fatty liver disease induced by maternal obesity is driven by metabolic rewiring of Kupffer cells
Naturegeneral

Fatty liver disease induced by maternal obesity is driven by metabolic rewiring of Kupffer cells

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5NUGMxVTIwczNqNEpTTXNkczdNR2l0elNINk9hejl4ZTVzU0hRMU94VURWclVpY1VZR1MzZFh2Tk5BYVJzTmFoZGJ3a0wxZktVUjZMOC04QWtHaDBzOEJZ?oc=5" target="_blank">Fatty liver disease induced by maternal obesity is driven by metabolic rewiring of Kupffer cells</a>  <font color="#6f6f6f">Nature</font>

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Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development
Naturegeneral

Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBnS2VjRTcxYWlBOV85Y3FJaEVHakhkX01NQTc3d0dqNGdESWZPTmNBNm5mV3ljRnE0Z3drUXlQLW0zMno0bTJ3MTAyWVgyUWMwSkhfS0VfYTBfeklVYU5Z?oc=5" target="_blank">Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development</a>  <font color="#6f6f6f">Nature</font>

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Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers
Natureworld

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFA2dWhTZ2NzMENUMzVKZjE1NzZmYWFpZGJNQzhyNFNYbjlNekFwVFZSeW05Y2s4NnI2dXBIYXNVWDdCbDBrN0dKN2F6ODgzdGVsRzVEdFQyTzRtb3FaY1BZ?oc=5" target="_blank">Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers</a>  <font color="#6f6f6f">Nature</font>

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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes
Naturegeneral

Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBibUg0RGJFWUoySWZiUGF0NzM5TnJ2OW80MmNfLU0tMkYxY2c0cjhxTjV3Y0V6d29reWRiNlhwcEJOeW1FcFRsT0x1WUplUnhRanlUUE8wRlVJeEhRMFNJ?oc=5" target="_blank">Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes</a>  <font color="#6f6f6f">Nature</font>

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Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells
Natureworld

Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9sZzBjeXJtbk5TZHc1anFGQUhCNXc1SzJIdk5SNnFaQXR3UlI5Y1Y5WnZUWEpNcndjVmt6QzhuTkZrUVFwM0F3SzNhdDcxUjRIVGtfbUdWM0ZPdmx2ZWdj?oc=5" target="_blank">Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells</a>  <font color="#6f6f6f">Nature</font>

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Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Naturegeneral

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1jNWs1NmZMRy1ycFhWNWpBTW13UlZSMHRZWExjRnRLTTE5dV9xS3Zsb2hpVFljRlR2emRKMWVfeURFSjVYdk14d1VZY09iNTh4MXFvdGt0UHc1VW5ZUEMw?oc=5" target="_blank">Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult</a>  <font color="#6f6f6f">Nature</font>

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T cell dysfunction induced by hepatocellular priming
Natureworld

T cell dysfunction induced by hepatocellular priming

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE8zRnlHek1TT1BQNTRsRjhmTktENmc2UDZNSU1hTXd5WVIyemxsc0M0V2VDTXFFTUhQVDNLQ3g4d1hLOVlmUUNBTlRhN3FGLVFZZGlUZnJOclhveWhtdVlz?oc=5" target="_blank">T cell dysfunction induced by hepatocellular priming</a>  <font color="#6f6f6f">Nature</font>

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Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis
Naturegeneral

Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFB3UkYtOUZHN1hMMUdwM0tQMUNHcm9ycm1hbmFQTF82YW1LV1lRb1Bwd21HcG5EUjBRcG9iSjFuVV9pSDRLV2VXNC1zQUdNZWNuMDZ5NlRWekhxb2ZxWGxj?oc=5" target="_blank">Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis</a>  <font color="#6f6f6f">Nature</font>

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Infiltrating macrophages replace Kupffer cells and play diverse roles in severe alcohol-associated hepatitis
Naturegeneral

Infiltrating macrophages replace Kupffer cells and play diverse roles in severe alcohol-associated hepatitis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9QRE5SbnIta3F3Qmc5WERSYkxjZzhnZ1VNZ0ROdXFfbXpzd09nWU5FbmloeVVxT2ItVjlzNm1NanBOWVRETEdJbGtQM2V2NGFfWFA3S0pYTDhYOGNlV3RJ?oc=5" target="_blank">Infiltrating macrophages replace Kupffer cells and play diverse roles in severe alcohol-associated hepatitis</a>  <font color="#6f6f6f">Nature</font>

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Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis
Natureworld

Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBUeTczWjBlZzlFQktmVDhQb2RTYmFTZHJ2YUkzbjhtalprdS0zYTBBa0lFczdycHkzVHpSM3dmNHpaYmtVaDNna0FFWFZsT2lEdEI2Tjc1WmhXUmtyZnlB?oc=5" target="_blank">Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis</a>  <font color="#6f6f6f">Nature</font>

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Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis
Naturegeneral

Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBVTmMxMGJaWHBJVTZaQThFNXU5c1RGYmRpOVRLT1B4MTM3SHdEMEw5TG54My1MT25iNEY5TzNBVzhIV1ZZVjhrMF85dDVjSFhoSUYzRldQOW55RjlhcWp3?oc=5" target="_blank">Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis</a>  <font color="#6f6f6f">Nature</font>

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Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice
Naturegeneral

Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE83Y1lGaENORmROT0F3R3FEWk43S1Z5eGN3UVYyTS0taVNTNGxnWjhZU0lUNjJnVTFtN2JEYTkyWW10NDZTNGZFS21lS0hRWXN2aEhKZUNEU1VWcGpRYV9J?oc=5" target="_blank">Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice</a>  <font color="#6f6f6f">Nature</font>

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Kupffer cells are essential for platelet-mediated thrombopoietin generation in the liver
PNASgeneral

Kupffer cells are essential for platelet-mediated thrombopoietin generation in the liver

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE1iT0cybzdHdnRXQlBxSzI1MV91enFwZURXLVVVYnV6akxmNTE2eDBLdkhJVlgtWVhudUZ2dHV3aGRWU1BhNjNHWndtQlpIMXM2TVF1NTI4eEtiMGFv?oc=5" target="_blank">Kupffer cells are essential for platelet-mediated thrombopoietin generation in the liver</a>  <font color="#6f6f6f">PNAS</font>

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Major roles of kupffer cells and macrophages in NAFLD development
Frontiersgeneral

Major roles of kupffer cells and macrophages in NAFLD development

<a href="https://news.google.com/rss/articles/CBMilgFBVV95cUxQU0xQZk1uRTlEYU5Dd0pxZVFvMHEzUjlKeExIYnpxUl9adGNMWG5fRkIxNmsxZDhxX281RFQ5V3k5NDZHNEh6Z2EzNUdoWktzWDFid2NTemRTZ0hXMzhsVkRzY3BiZjZsakMtYmt3RmlZNXQ4R0VTMlV6UzVXSlRIWEU4bHE0cDVDc1RQa2VOeUw5c2RSYXc?oc=5" target="_blank">Major roles of kupffer cells and macrophages in NAFLD development</a>  <font color="#6f6f6f">Frontiers</font>

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Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
Naturegeneral

Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE81dEt6WmkyLVBkQ0ktNGJkT25tUWFYQXRaT09aOWZTd2RqcWdBVFVpUzh5bTMxY0JiOW5Tbnh5WVZFX3N3R0dmOU9RRWk4Mlc4T2U0SDhhOGF0QXJUS1k0?oc=5" target="_blank">Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells</a>  <font color="#6f6f6f">Nature</font>

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Role of Kupffer cells in tolerance induction after liver transplantation
Frontiersgeneral

Role of Kupffer cells in tolerance induction after liver transplantation

<a href="https://news.google.com/rss/articles/CBMirAFBVV95cUxNcFVTa0NHWjZOWTlOT29WbDNoMnRMdzRRSVVYd2JaTDl5YWFHTTBPV3RxdXJoZVJVT2k4c0xVUGo5WmpEcEw2SDJRYWVDU0taa2ZhUjU2VEQzR1BTNUpmRU0zajNWV21LODNjbDFEWmdvRmFoSkk4cFNZc1dpMnhrRElXTXliTGhFU0ttMFBZV2J2T2FpV3czVl8xVTB5Qnl4UU1xdzMwUDRmd3JL?oc=5" target="_blank">Role of Kupffer cells in tolerance induction after liver transplantation</a>  <font color="#6f6f6f">Frontiers</font>

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Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression
Natureworld

Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE92NFB0RWZGa1NvcjBDOFhlVElTOXJFaDFRZXFZT0cweHhiTnlxVldQQUt0U016dEtONHdveTQ2R2VoQ3hyUnFRM19PRm1mQmE3WWZNWEdENnRENjgyLVA0?oc=5" target="_blank">Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression</a>  <font color="#6f6f6f">Nature</font>

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Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis
Science | AAASgeneral

Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis

<a href="https://news.google.com/rss/articles/CBMiZEFVX3lxTE12U29nZVdVMlotUENnUXhHbDFEWlF5a0hycUVBX2p6cmlzenR2ZVhpMFh5LWZmSjFDaGotcVNDdkg1VUljNGdTZ2QxNC1mZmFWUFlPQnd3akktRFpWLU4yeFNJVlM?oc=5" target="_blank">Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis</a>  <font color="#6f6f6f">Science | AAAS</font>

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Viral-Directed Augmentation of Kupffer Cell Cross-Presentation Provokes Antitumor Immunity Against Liver Metastasis
Wiley & Sonstech

Viral-Directed Augmentation of Kupffer Cell Cross-Presentation Provokes Antitumor Immunity Against Liver Metastasis

<a href="https://news.google.com/rss/articles/CBMidkFVX3lxTE5Ua052UkNTckZLNkVGcndGcmp0STR1NzNnSzdSZGgtZUgyR0YtTS14MG5wWGItRHZKNnRJYnNoUDQ2VmpGcUFZTVQyUi1fQWtiUUdRQkF1LVd1bFNrQXBzT2tmOEF3Z054QU9EVnJSYXMwV3FsRXc?oc=5" target="_blank">Viral-Directed Augmentation of Kupffer Cell Cross-Presentation Provokes Antitumor Immunity Against Liver Metastasis</a>  <font color="#6f6f6f">Wiley & Sons</font>

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Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus
Wiley & Sonsworld

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

<a href="https://news.google.com/rss/articles/CBMicEFVX3lxTE9Jb1RXcEJfaWtpRElMbUdaUlFxQWpTdFkzNlN3aU9TRE82cW11RUZLMzFqeDRZa3A4UmYxd1JSaHdRT24wRFVEaUVsTm5uQTBISUl0MTFIR1Q0UmMwYzNhNnB1UjMxaW1OaGprdkgzMWY?oc=5" target="_blank">Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus</a>  <font color="#6f6f6f">Wiley & Sons</font>

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GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway
Naturegeneral

GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5oVkdPeWEyMWY4cFY1UDhCMGwzTzNtZVpBYXN0ZDJkVXNXa3RGNlJpRGk1bGxlbGZrbjVmcThlbld5MjBUX1VVdGRiZ0RzS3RxdlBCZF9Bd3dOYVExc2hF?oc=5" target="_blank">GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway</a>  <font color="#6f6f6f">Nature</font>

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Immunopathogenic mechanisms and immunoregulatory therapies in MASLD | Cellular & Molecular Immunology
Natureworld

Immunopathogenic mechanisms and immunoregulatory therapies in MASLD | Cellular & Molecular Immunology

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5KRzdUVXlueTgyTDZ1RVF3YlVuU2dwWXFvV2lzdk85TXNVSGE5Z0lDVzVHQjZlR0lNS3pWZlNvdjN5REhJaW8wMngtZmhpY0h1c21Qdk1ZM0xqemVDQjFV?oc=5" target="_blank">Immunopathogenic mechanisms and immunoregulatory therapies in MASLD | Cellular & Molecular Immunology</a>  <font color="#6f6f6f">Nature</font>

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