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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "In vivo base editing of C" (30 stories)

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In vivo CRISPR base editing for treatment of Huntington’s disease
Lead StoryNatureworld
Jul 29

In vivo CRISPR base editing for treatment of Huntington’s disease

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5GQjJRN0dPaTdYLWFUNzRZVmVER2trb0haVExzOWl1MzlQMlZEcWxxa0ZJTk52OURzRUE4WG1GWjB6eWMxd3pQa1lXMHIzQW50bTdlOWFjOWVWMFhFYTBz?oc=5" target="_blank">In vivo CRISPR base editing for treatment of Huntington’s disease</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "In vivo base editing of C"

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29 stories displayed
In Vivo Base Editing for Neonatal Inborn Errors of Metabolism: Clinical Progress, N-of-1 Therapy, and the Ethics of Bespoke Genetic Medicine
Cureusgeneral

In Vivo Base Editing for Neonatal Inborn Errors of Metabolism: Clinical Progress, N-of-1 Therapy, and the Ethics of Bespoke Genetic Medicine

<a href="https://news.google.com/rss/articles/CBMihwJBVV95cUxOS285eVozdEgzMlU4UEZ1UzZwVDl3MnZ3ZWZWa2pESF93c0hia080Ti12NGNSTWFHZnYxai1QWFNqWHRQVm4yZkFHOVJvS1o1Q2pQUFQ2eVo4TlNCajl2NWdoMVdZLU80N1JjdlR6SFFYWjh1SE16ckhGQ3RUODJndlBGSEFYb0FhWXJIazZHQjJENGdMWTVxc2tsckt1UVlIRlBKTEhKdUtScDVlOXcyRzJkX0dITmcyNmU3bTN0dWR6NzdwcDcyLVVTN0pqdXhmaF8zTFBNQkZid0xFdjlnZUlBSkozT2pmc2NYbnNBY0pRYUI5elF2R3lpMnMzOHl0aVJ6Si1mSQ?oc=5" target="_blank">In Vivo Base Editing for Neonatal Inborn Errors of Metabolism: Clinical Progress, N-of-1 Therapy, and the Ethics of Bespoke Genetic Medicine</a>  <font color="#6f6f6f">Cureus</font>

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In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia
NEJMgeneral

In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia

<a href="https://news.google.com/rss/articles/CBMiYEFVX3lxTE5PV3pvSTk0M0JieWtHeEVvOGptT1E2anV5LXItN2JLeG1ZZDZRWldxQmdnbkhHa29PX1dRVmt5LWdJbUZFQlpBemVvdVNQSlhqZWdoWWk2a2drNUdBTjdCRA?oc=5" target="_blank">In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia</a>  <font color="#6f6f6f">NEJM</font>

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Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine
Wiley Online Librarygeneral

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine

<a href="https://news.google.com/rss/articles/CBMia0FVX3lxTE1RU2tfYUE4THdlek8zZk5iTU16T2JVVWZCNWt4elBqU1FqTkRRZ2hSTExFNUZub3lyME00MFBWNnZUMTFnZzRFdXpKMHhlVFRzZUxGWm1KVGNDb2ltYjdoTlltcXdxdXo1bG0w?oc=5" target="_blank">Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine</a>  <font color="#6f6f6f">Wiley Online Library</font>

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A single dose of Lilly's PCSK9 base editor, VERVE-102, reduced PCSK9 by up to 88% and LDL-C by up to 62%, with durable effects supporting its potential as a one-time treatment for hypercholesterolemia
Eli Lillygeneral

A single dose of Lilly's PCSK9 base editor, VERVE-102, reduced PCSK9 by up to 88% and LDL-C by up to 62%, with durable effects supporting its potential as a one-time treatment for hypercholesterolemia

<a href="https://news.google.com/rss/articles/CBMiwwFBVV95cUxQc2tVZUVSeldLXzY4TzJtM1NtYWVMZVRiV0t4eWozcDE2cWZMWG9DRDhDcS1ySkZGOTN0TWUzQ3FFb2tLcU1lTkRxdURZdXBLMUZKLVk2YmdKNnlodVdOaXZMWEhRM1c4bGJ1S3NCaXJhTktQUnd4bTBycG5ja1lzWUJWTnNndGd5c3l5MGN5cnN6WFpDYy1hZnU5eTdja1lFcEV6UlpvYTV4aGttWWF0c0VLeF9sV0FEd2ZtT3VOWUhicGc?oc=5" target="_blank">A single dose of Lilly's PCSK9 base editor, VERVE-102, reduced PCSK9 by up to 88% and LDL-C by up to 62%, with durable effects supporting its potential as a one-time treatment for hypercholesterolemia</a>  <font color="#6f6f6f">Eli Lilly</font>

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A new gene editing approach shields the immune system from HIV
Fred Hutchinson Cancer Research Centerworld

A new gene editing approach shields the immune system from HIV

<a href="https://news.google.com/rss/articles/CBMifkFVX3lxTE5TZG9LWlNhQi12US1ESUtLU3VmdGlUTC0zc1ZVVkVyaW1WMHpTb3owMFNiR3p3eWctZzdneW5HVnczZlZMWUQ3N1BXc2Rvb0RVZi1CVFpKYW5IUHBYRjU2VGdYTGc3T2hhTG5mVzNNcGJQWnJnVTVrWjVwMEhkQQ?oc=5" target="_blank">A new gene editing approach shields the immune system from HIV</a>  <font color="#6f6f6f">Fred Hutchinson Cancer Research Center</font>

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In vivo base editing rescues liver pathophysiology and peroxisome dysfunction in a mouse model of Zellweger spectrum disorder
Natureworld

In vivo base editing rescues liver pathophysiology and peroxisome dysfunction in a mouse model of Zellweger spectrum disorder

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE05SlVoZmxpa0hfaURUWHkxd3FlMUIxRENmVDcza0pDa3BkbDNSbXlfR01feHdkRE1adkYwblpkVGVydmluSHZvbjBmX01Ndi1iUnZHZVNCSGc0QVV6N2hF?oc=5" target="_blank">In vivo base editing rescues liver pathophysiology and peroxisome dysfunction in a mouse model of Zellweger spectrum disorder</a>  <font color="#6f6f6f">Nature</font>

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Cell Therapy Weekly: Base Editing Therapy for Hypercholesterolemia
RegMedNetgeneral

Cell Therapy Weekly: Base Editing Therapy for Hypercholesterolemia

<a href="https://news.google.com/rss/articles/CBMilwFBVV95cUxPeTVvdjVXa0Z6UXVOMDVEZWZJUG9aS3hhOUJJSzBPbkUybGdBT1VLblR2SjVYdHJEQ2pOX2ZEaXlEZ2NEVmd3clY0cklySFByWF9rVlVfc3BxUmpKX283VWplOHBGbzNCcVNFcjhKSFFTcFpIbFJSM3ZfVENZT3pqdHJCa3k4UkR5UnI0M3pzc1k0bnBDNmlr?oc=5" target="_blank">Cell Therapy Weekly: Base Editing Therapy for Hypercholesterolemia</a>  <font color="#6f6f6f">RegMedNet</font>

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VERVE-102 Lowers PCSK9, LDL-C in Interim Phase 1b Hypercholesterolemia Data
HCPLivegeneral

VERVE-102 Lowers PCSK9, LDL-C in Interim Phase 1b Hypercholesterolemia Data

<a href="https://news.google.com/rss/articles/CBMiogFBVV95cUxPWkhrUFJNR0ZQZ0ZPVmpzY0RzRXFMQVo4X2U2clpJaUd1Q3dBX25EWHpmYTBTTG9Fd0ZKWmpzaUJOVWcxX1lhaVhWRm9vWGtHZ0hubGdnQWtxOVZoeG9nVVFVRHd1Um9ZbVJWSlcxWUNCMHZjOEFocWNkaVNjdDV0X1NGVlZyNjdPb2xwdEpySTAyVTc5cWJmVjlabllFcnJaRnc?oc=5" target="_blank">VERVE-102 Lowers PCSK9, LDL-C in Interim Phase 1b Hypercholesterolemia Data</a>  <font color="#6f6f6f">HCPLive</font>

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Heart-2: VERVE-102 Lowers LDL-C in Phase 1b Hypercholesterolemia Trial
Patient Care Onlinegeneral

Heart-2: VERVE-102 Lowers LDL-C in Phase 1b Hypercholesterolemia Trial

<a href="https://news.google.com/rss/articles/CBMirAFBVV95cUxOdm1ma1MtOG1yeGU1NmZZaENvNUVKdHpVV2d6Q1RrT0NIVFRTbXZsa05uN3duY1VmTHNRNUpaakhjcEUydlNzeVRfLUhnRGFCWlZtVTVNUXRLODRJLVIybDFXUVVIRWYyMVNvQXVHc1JIZlVwN010c2pMc05WU29RTGttR040N3NaeC1iT0lFVFE0TzZIUmZnS1BRdnhRUkJ6bGR6cGdmSWhGUFJU?oc=5" target="_blank">Heart-2: VERVE-102 Lowers LDL-C in Phase 1b Hypercholesterolemia Trial</a>  <font color="#6f6f6f">Patient Care Online</font>

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Engineered deaminases enable precise RNA base editing
CRISPR Medicine Newsgeneral

Engineered deaminases enable precise RNA base editing

<a href="https://news.google.com/rss/articles/CBMilAFBVV95cUxNdERnSDdQSzh2TXZGajBmb0tnbzVUNW9MTDdZN01nQWpUbHJMSTBLc3ZLanBENzRMT0NyTjVaMi1ueE1ZanU4MXJXbkxkX0tha2VjWjdiZHpuTklVUnNudmltbk01VHJFM096bHhRUUJlNG84RUtvSXZXMnVGdEJ6ckRCZjhnT3dvS2JHQ2Y1OFEwZkQ2?oc=5" target="_blank">Engineered deaminases enable precise RNA base editing</a>  <font color="#6f6f6f">CRISPR Medicine News</font>

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Inducible, split base editors for in vivo cancer functional genomics
Natureworld

Inducible, split base editors for in vivo cancer functional genomics

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1KalVZMmJHbGtNZEtMQV9vbFlHNUp3dDFuWHBOQ1BJdDhudXFaczJNQ21wUHN4b0FOdE9Zak9jb3dsc2J2bFdFOUVrUTA1ZVB0Qkh0QjltU28tMzVnU2dr?oc=5" target="_blank">Inducible, split base editors for in vivo cancer functional genomics</a>  <font color="#6f6f6f">Nature</font>

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In vivo base editing of Chd3 rescues behavioural abnormalities in mice
Naturegeneral

In vivo base editing of Chd3 rescues behavioural abnormalities in mice

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBvREVXYzZadzZ1YmRqVmV4ZXQySVZUdFlQUXA3bS13X3RtVWNnbzlKOWFaakJkTVR1cnkzb3lYa1c5TWxMLVVfb3JDT1ZxMFZDcHR1OFdzZVliMjllTGcw?oc=5" target="_blank">In vivo base editing of Chd3 rescues behavioural abnormalities in mice</a>  <font color="#6f6f6f">Nature</font>

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In vivo base editing rescues ADPKD in a humanized mouse model
Naturegeneral

In vivo base editing rescues ADPKD in a humanized mouse model

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9lWHFNZkMzckpqYlNROG0takcxbnNVeHk2S2dOQmF6Ti0wci1uTEJaOERYM2tabmcxdlF5ZlY5cGtoMUNWN09vUWpFUU9TSGQ5T1VoME1XcVRNa1J3TVdz?oc=5" target="_blank">In vivo base editing rescues ADPKD in a humanized mouse model</a>  <font color="#6f6f6f">Nature</font>

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Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins
Naturegeneral

Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1IekFGUTVkMnFja0hnV3E5dnBoS2pfLTJWT2JIUS1kR21PckJQbTJDWm9tUVVmd1NOeUQwMHExRExTeHkweTJBYkJhOUl1eVFPRlkxaWZiZEtySWtjRWpZ?oc=5" target="_blank">Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins</a>  <font color="#6f6f6f">Nature</font>

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Engineered base editors with reduced bystander editing through directed evolution
Naturegeneral

Engineered base editors with reduced bystander editing through directed evolution

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBUT2J4dGhSWWRNUEJuWDdhWHJjNldIVko1ZzlNaS1MUjRPaFM2R3VVSjBYNXQyYkxmZTVmMy1FMDRVdkdrSy1Wa01IZi1sSEx6cGtDUEQ5dW1hZUV3Y0dV?oc=5" target="_blank">Engineered base editors with reduced bystander editing through directed evolution</a>  <font color="#6f6f6f">Nature</font>

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Coiled-coil heterodimer-mediated split base editing systems enable flexible and robust nucleotide substitutions
Naturegeneral

Coiled-coil heterodimer-mediated split base editing systems enable flexible and robust nucleotide substitutions

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBQakF0XzJGVG9BNURLekdGTHJ0YThieXZGaUd3WW1FQjI4bnQ5Q3VBUTFqZFp3NHJPVjNnLURHblJXQTkyNFJkQUE1TnMzS0tNbnAxTXdyWVZkTVZ2R2NJ?oc=5" target="_blank">Coiled-coil heterodimer-mediated split base editing systems enable flexible and robust nucleotide substitutions</a>  <font color="#6f6f6f">Nature</font>

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Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs
Naturegeneral

Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9fYU5UOHhYRENGVVlSZ3lYX29pOV9Yazk4RW51ZXZRcXpDSmlHQnlfMmdGVHd0ZkFVQ01iczdkNjh0SWFMVC1XOHBIVG9GZEtPQWFtMnJHcUFGZjVZeVVr?oc=5" target="_blank">Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs</a>  <font color="#6f6f6f">Nature</font>

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A split and inducible adenine base editor for precise in vivo base editing
Naturegeneral

A split and inducible adenine base editor for precise in vivo base editing

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBLNEZxT09nRXBESUZjZUtWSE4yMWQzSTZtZE8yaWVZZW5Ha3lnZzFyOWt5a0hkOHY1ZE5YZ015Rl9xMTJmT3pwUGkxLVp0Q254UzRFeDdvRTZhcmFoYlE0?oc=5" target="_blank">A split and inducible adenine base editor for precise in vivo base editing</a>  <font color="#6f6f6f">Nature</font>

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Efficient precise in vivo base editing in adult dystrophic mice
Naturegeneral

Efficient precise in vivo base editing in adult dystrophic mice

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1MXzdScU50Vm5mc1lENVo1QkI3eDZQRkxrQnMtM0xXbnFsWXM3engzdjlhbUV0NDBEZWw4eWNveUhYb2hjRFU3SFBYYjhIODFJcFBncnVGVi1mU0VySHlz?oc=5" target="_blank">Efficient precise in vivo base editing in adult dystrophic mice</a>  <font color="#6f6f6f">Nature</font>

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In vivo base editing extends lifespan of a humanized mouse model of prion disease
Naturegeneral

In vivo base editing extends lifespan of a humanized mouse model of prion disease

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBPWmFWMjVmNHlkenZoNURBMndTZ3Z0WlowTUw1cFAwZ0QzYnVZYzdoZk1jU0ExVVJNZG56a2dQRnEwMnZ2ZW5GcDdWNktzTGtQUFNaYnJGTjFuNUhXbUow?oc=5" target="_blank">In vivo base editing extends lifespan of a humanized mouse model of prion disease</a>  <font color="#6f6f6f">Nature</font>

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Optimized in vivo base editing restores auditory function in a DFNA15 mouse model
Natureworld

Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1jaXA4M3JXLTJnaHBEYkMya2hINUdnMk9TcEdmbGRCc2VMNjMteERlM2N4cUI1X0ltTUs1NGlhX05zTTdtX3ktTmdoMXEzWmlsYWpocVp4RnNiRERFaE5v?oc=5" target="_blank">Optimized in vivo base editing restores auditory function in a DFNA15 mouse model</a>  <font color="#6f6f6f">Nature</font>

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A motif preferred adenine base editor with minimal bystander and off-targets editing
Naturegeneral

A motif preferred adenine base editor with minimal bystander and off-targets editing

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9BSFk4SkNFN3pHenNORDNiN1FNNUFXS2x6TEVPcEk0TnJHWXl5VTZXeFVsQUREYzlmc0plSVltcG52eDB0LWI3clRZNU5meGxsUjBlc2k3SXFreGNFcmVF?oc=5" target="_blank">A motif preferred adenine base editor with minimal bystander and off-targets editing</a>  <font color="#6f6f6f">Nature</font>

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Explainer: What Are Base Editors and How Do They Work?
CRISPR Medicine Newstech

Explainer: What Are Base Editors and How Do They Work?

<a href="https://news.google.com/rss/articles/CBMikwFBVV95cUxQcTlmdDNCWDNlSGM2LTFsS3JNZnpFRFRFXzVuYnBLeEhOMlpQQ3diZFN2Z29LVE4xZEJiY0Jnb3BFdmlsVk9OSTVBT256RHV3MmpRU1ZsREU1MFNzMUQ4ZEplXzZfcWw4UmVzSXd0ZC1kVzh0XzJ6VDIyQmExWFljQ1dXYmkxX2pQd1J5S3lSc2JFMzQ?oc=5" target="_blank">Explainer: What Are Base Editors and How Do They Work?</a>  <font color="#6f6f6f">CRISPR Medicine News</font>

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High-efficiency base editing in the retina in primates and human tissues
Naturegeneral

High-efficiency base editing in the retina in primates and human tissues

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBtWkhwbklGanhRcHd3NG1uWVBSMHl5WWg0R2hmUjBVd21TaTVxRHlkQTVBZWZFT0hpOHloSTN1ZFJtdHgtTC0tUThuVTJyQU5TNmt0bWpkeUNiaENYV293?oc=5" target="_blank">High-efficiency base editing in the retina in primates and human tissues</a>  <font color="#6f6f6f">Nature</font>

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Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors
Naturegeneral

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE91VlR3MjNUTGJfM2VkNllyNWw1UUFDdVpHb1ZGMnJObzh6RzZWYkpYVDFPNVFBLWJDOFFRQlVKLXh2Zm5BeDVHenVjdXJaX0pRYTAwekxKMjBIanFkZVln?oc=5" target="_blank">Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors</a>  <font color="#6f6f6f">Nature</font>

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In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration
Naturegeneral

In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5RZnNBMVp6OEpCeFJrZ3pKTENaa2RITmpOejJFVTJkekoyekhTdTB5RDQwYks3bVdQeWFReHcxMTJ5N1VRbFJLV1VQY0NiaTRBaWtBcXNrbkNwWEhldjdV?oc=5" target="_blank">In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration</a>  <font color="#6f6f6f">Nature</font>

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Base Editing Gene Therapy for Heterozygous Familial Hypercholesterolemia
medRxivgeneral

Base Editing Gene Therapy for Heterozygous Familial Hypercholesterolemia

<a href="https://news.google.com/rss/articles/CBMie0FVX3lxTFBJS2xhUTdOd1doUG5mQTF2WFdZeU1mdWxKQ3ZkNEFFWUpEUmlIMk1tWTMxenlkczBWT05Za2VzTDF4QnNRUldRM3lPWnVxa2NrRlVPMG43ODRQOHE0YnJHbERwUnEzUFItOG44Sno0dGdKX0VxM3loejlFOA?oc=5" target="_blank">Base Editing Gene Therapy for Heterozygous Familial Hypercholesterolemia</a>  <font color="#6f6f6f">medRxiv</font>

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In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
Naturegeneral

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9LalRzSkp2aUJ3MU1xSGFGZktMWENMUTFIQ3dveXY2UU42bjI0R0JQZkNFaTZ4ZWUxa0JwNXNVZHNtZkV1WnNSYWMzUnNOeWtkUkxlZTYxNGdsSFk1Vy1J?oc=5" target="_blank">In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels</a>  <font color="#6f6f6f">Nature</font>

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A Cas3-base editing tool for targetable in vivo mutagenesis
Naturegeneral

A Cas3-base editing tool for targetable in vivo mutagenesis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ENUFzcURZbHBneDB6Yjktem5XT1dNcEloSTZkeHJiZklObHl1aGh1eEU4dGZXREdJT211VVV2ZEY5M1ZvRkMzbksteDM3RlVlNzdfNVR6emw0V2VOdmFV?oc=5" target="_blank">A Cas3-base editing tool for targetable in vivo mutagenesis</a>  <font color="#6f6f6f">Nature</font>

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