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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Deep mutation, insertion" (30 stories)

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Scanning the horizon: deep mutational scanning approaches in virology
Lead StoryASM Journalsgeneral
Jun 10

Scanning the horizon: deep mutational scanning approaches in virology

<a href="https://news.google.com/rss/articles/CBMiY0FVX3lxTFByanFSaG9ET2YwUC1ZUVhLNzd6akhqY3FkcmxwS0wzdUUwb2pWUGhQTWtfQm56UnJNQ1JXVDJiX3FJRU9uMDF1YW5qOFFFUjRvWEtqWmNJcl9Ea0FBb3ZvSFR6bw?oc=5" target="_blank">Scanning the horizon: deep mutational scanning approaches in virology</a>  <font color="#6f6f6f">ASM Journals</font>

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Search Results for "Deep mutation, insertion"

Updated every 3 minutes via FreeNewsApi, GNews, Currents API & Google News

29 stories displayed
Deep mutation, insertion and deletion scanning across the Enterovirus A proteome reveals constraints shaping viral evolution
Naturetech

Deep mutation, insertion and deletion scanning across the Enterovirus A proteome reveals constraints shaping viral evolution

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9hY2g0M2NKel95ZmZrLVlXRTJESmZzT2xoaUdlVlFyNHNNckZuS2l2NjJrMXgyNVBNU2czWE9aNjQ3Q1RCWXdObVlRQ2Z4OHFHSmFxOFFmTHdaYkt4Q25B?oc=5" target="_blank">Deep mutation, insertion and deletion scanning across the Enterovirus A proteome reveals constraints shaping viral evolution</a>  <font color="#6f6f6f">Nature</font>

Massively parallel quantification of mutational impact on IAPP amyloid formation
Naturegeneral

Massively parallel quantification of mutational impact on IAPP amyloid formation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE00a0V0RXZWM0NwTmhrTF9DdzFfdVhHdnlnUFNkTV9iMzRXVXd1dWhiNEZRVXpCSUttSEljZ2JRSE5MQlNSVjlVRVU0Y3VJbTJBY1NKVGVlNjVsV3JUSGRj?oc=5" target="_blank">Massively parallel quantification of mutational impact on IAPP amyloid formation</a>  <font color="#6f6f6f">Nature</font>

Phage-assisted evolution of allosteric protein switches
Naturegeneral

Phage-assisted evolution of allosteric protein switches

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBXVm5zOWlDa0Y0dHU5WTdkcWdsS053eWpuTjJ1bXNGWXRhNFNNWXdZRDZSRHlyRE9xUUxnQUkyRHY1dHQ3U0FHR3lsLWVfZE0yeWhXam5vMnFtcGk1YkZZ?oc=5" target="_blank">Phage-assisted evolution of allosteric protein switches</a>  <font color="#6f6f6f">Nature</font>

Regulatory grammar in human promoters uncovered by MPRA-based deep learning
Natureworld

Regulatory grammar in human promoters uncovered by MPRA-based deep learning

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFB1Nm5Vc296b1JhS25aN3c3QWVxeFRaSG1BWXByNXNBTTYtMHlQY0tuaGtPQlpvTjJHUTlSX3JYT0NrYWtZOTNfZWFtTE42TF90TWJVRTgyZ293TGdmOF8w?oc=5" target="_blank">Regulatory grammar in human promoters uncovered by MPRA-based deep learning</a>  <font color="#6f6f6f">Nature</font>

Site-specific DNA insertion into the human genome with engineered recombinases
Naturegeneral

Site-specific DNA insertion into the human genome with engineered recombinases

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFB0elpCOU9ncGEwYjYzd1dWVlVuSVpqUGRTSl9Qdmp4dWs1eVBaZGU5SHRJMkVNWVh4dlF6dUpMR2xIN2lfY2twcHFRdjBUR05FeGZsdDNmcUR1LUZZQzFv?oc=5" target="_blank">Site-specific DNA insertion into the human genome with engineered recombinases</a>  <font color="#6f6f6f">Nature</font>

Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function
Natureworld

Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE02YVRwSk9DYXI4LTZMYTkyMzQxMUNpZ01nV1hoRWZrbktmRVZHNkpJSENtSkRscTlXNDdzdVhEWTlEUS02UXZzZWxvRFR0UTlnOTdQR2U2elptYnI2SEpr?oc=5" target="_blank">Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function</a>  <font color="#6f6f6f">Nature</font>

Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing
Naturegeneral

Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5ra2N6MGlKcFhyRTVEeGNUdkxPQ3VvRjJLc3hZNDd1U21HcGkwR21SSWw1ci1DX2g0RVNyNklqSGdRSHdDX1FhdEswWVZCLUxxdkRVQkpsWnpwYlo2N1JV?oc=5" target="_blank">Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing</a>  <font color="#6f6f6f">Nature</font>

Deep mutational scanning identifies Cas1 and Cas2 variants that enhance type II-A CRISPR-Cas spacer acquisition
Naturescience

Deep mutational scanning identifies Cas1 and Cas2 variants that enhance type II-A CRISPR-Cas spacer acquisition

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE11U1BlNk9rQk04b2Etc3hDMFhhLUV6Q1NDQVI1a3ZxOEJUY01fWlRFZTBrQVFIc0REMGhRb0lzR045WFg5dHEzU0U5akdncDJCTXpLdldvU1BQbkFpcnFB?oc=5" target="_blank">Deep mutational scanning identifies Cas1 and Cas2 variants that enhance type II-A CRISPR-Cas spacer acquisition</a>  <font color="#6f6f6f">Nature</font>

Deep mutational scanning reveals EGFR mutations conferring resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945
Naturegeneral

Deep mutational scanning reveals EGFR mutations conferring resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1VQnNZbTZUSkJMeDNsdlN5eHJxLTBzMW0yZFpZT0lxY3Y4VnBjT2dOd0Y3R2RHWmNOOG9tMWhaNHgxVThvTHVyMWtsbmYyeGEzbktPMlFlaXp4QTE5WFpJ?oc=5" target="_blank">Deep mutational scanning reveals EGFR mutations conferring resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945</a>  <font color="#6f6f6f">Nature</font>

Genotype-by-inhibitor interactions to dissect enterovirus replication
Naturegeneral

Genotype-by-inhibitor interactions to dissect enterovirus replication

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9UU0dNMkl5aWhZakJoZnZPR0MxVUFIaEZPN2RLTnRsOEFXYXN4dG1uYlk0b3g0N0tENnJDRERvWjJoZjdaaDJEbUNRNy1KcUljY0dRcnF3bG1XeTNGdkZv?oc=5" target="_blank">Genotype-by-inhibitor interactions to dissect enterovirus replication</a>  <font color="#6f6f6f">Nature</font>

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations
Naturegeneral

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE54MTZQRFVzdWpnWGtaYTZsQ05rZUdhanZPTG0yRkFJaWhPNU9ITHVCTk1RTDg5TVJtTEN3TGtxQmZqVmFDeGNUUWZqeVdmQTJOcWdQU1JIa2pEMzZUYXJ3?oc=5" target="_blank">Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations</a>  <font color="#6f6f6f">Nature</font>

Site-saturation mutagenesis of 500 human protein domains
Naturetech

Site-saturation mutagenesis of 500 human protein domains

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5WMlM4Z1k1SG5Yb19rTnBwUmZKUUtDeW50YV92aV9wUl9XSVhKZHhHS2V4MGZicHpGUm4yYVI1LTFGMUVGaTJlcFVXWlNiSzlJWDhPVVQ5YWRnOWpUVlhr?oc=5" target="_blank">Site-saturation mutagenesis of 500 human protein domains</a>  <font color="#6f6f6f">Nature</font>

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations
Natureworld

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBlNG9fTjEwZ3k4c29rOUVjTXJFZll3aDJ6MGRSNWNueE9hRndsSnRsZGNqUzNLWVJYaWZ6cnQ3M3lKNk12LWVRNGpIV20xemNRYUxRcWtTdGtXSnU0cG44?oc=5" target="_blank">Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations</a>  <font color="#6f6f6f">Nature</font>

Paying attention to the SARS-CoV-2 dialect : a deep neural network approach to predicting novel protein mutations
Naturegeneral

Paying attention to the SARS-CoV-2 dialect : a deep neural network approach to predicting novel protein mutations

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE12bE1wcEdkTlZBellzcHgxQ1ZuOXNhV3J0VUdyNnVENjgyaGtqZmMyVWFBbUZRdERBUkQ0RUllTXY1Z0ZsZnJIZmExbmZKckxMWWYtNGd6WkdZZFZFNlQw?oc=5" target="_blank">Paying attention to the SARS-CoV-2 dialect : a deep neural network approach to predicting novel protein mutations</a>  <font color="#6f6f6f">Nature</font>

Image-based DNA sequencing encoding for detecting low-mosaicism somatic mobile element insertions
Naturetech

Image-based DNA sequencing encoding for detecting low-mosaicism somatic mobile element insertions

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE96eFhMTmw3ZE91SmpZbjk0UWtwNmJLc3B2UVBCcWxIcXg1ZjY2aVNIbjhYejNlT0xjeURvVzZfWDNRVTZIcGJ3S0VfVnlmdDBGSy0zdEc1M2o3Ykkxang4?oc=5" target="_blank">Image-based DNA sequencing encoding for detecting low-mosaicism somatic mobile element insertions</a>  <font color="#6f6f6f">Nature</font>

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation
Natureworld

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9hd3kxMUZLZVlFcEZhMHljcVBvYnUxRmc5TmVTbkRhNVFNaG9DX2JYcEQ1QVZjLW5mQnY1YWc1VDdmZWcwMF9QWklGa284NTlaZEhoR3c2MGEtcWFvQWIw?oc=5" target="_blank">An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation</a>  <font color="#6f6f6f">Nature</font>

Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Naturegeneral

Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1WWjVJVXZkaWZKSFNwOTdNTEUtclpRWjBMME5qRUFUeVdIeXhiWVlieTNzaEU5RndYTm9JaWJVLVNzMHdKVU9wWUJmeENsX3BtaHJRT3lvZFkzSWZER2Vz?oc=5" target="_blank">Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering</a>  <font color="#6f6f6f">Nature</font>

Reverse mutational scanning of SARS-CoV-2 spike BA.2.86 identifies epitopes contributing to immune escape from polyclonal sera
Natureworld

Reverse mutational scanning of SARS-CoV-2 spike BA.2.86 identifies epitopes contributing to immune escape from polyclonal sera

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1VZWV2aFBleVg5Y3N1NmNEYmZMY1p3alNXUzhDbU0zalhNTkU2Y1NzZzdoUlh6dU0wVUtFU3NEV3llV2lhbDZ4ci1qUXhQdnpuc2trclBIdWhEVGxRZnpv?oc=5" target="_blank">Reverse mutational scanning of SARS-CoV-2 spike BA.2.86 identifies epitopes contributing to immune escape from polyclonal sera</a>  <font color="#6f6f6f">Nature</font>

ProTInSeq: transposon insertion tracking by ultra-deep DNA sequencing to identify translated large and small ORFs
Naturegeneral

ProTInSeq: transposon insertion tracking by ultra-deep DNA sequencing to identify translated large and small ORFs

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9hT1BOeElMaWVJRDFfUXZSU3ctWUFMUDNwSHA4ME1kOVdjWEFuM1Y3MUJCUVZlLW5Udms1OUc3NjgzWVVKb1RmdEl2QTRnRGlqUWI4aWsxaXFEQy01Z0RB?oc=5" target="_blank">ProTInSeq: transposon insertion tracking by ultra-deep DNA sequencing to identify translated large and small ORFs</a>  <font color="#6f6f6f">Nature</font>

Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis
Naturescience

Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5jM0xLS05ZZzFqc2p4S3JnN25fWnNYNDRuTWVkejY2S1k0V2JOczF0VndLbWRoZll2a2E2cWxseGNsRmw1YU1rVHJrSVBWdGE4NmhnTjNBWDlOWV9kYmNz?oc=5" target="_blank">Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis</a>  <font color="#6f6f6f">Nature</font>

Allosteric and energetic remodeling of a PDZ domain by protein domain extensions
Naturetech

Allosteric and energetic remodeling of a PDZ domain by protein domain extensions

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBmNllrVmJvRHBoaUd5Tjc3Nm5NREI1ZU9RWWdKM3F1TW15aDR6ZUVZaG9NeW5xWnZhZW1aRU9DWk8xV0c1Y3RmaFR1RXMwbzZXM1ZlTHdzTVBucHRRbEZN?oc=5" target="_blank">Allosteric and energetic remodeling of a PDZ domain by protein domain extensions</a>  <font color="#6f6f6f">Nature</font>

Mapping cis -regulatory mutations at scale in sorghum enables modulation of gene expression
Naturegeneral

Mapping cis -regulatory mutations at scale in sorghum enables modulation of gene expression

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFA4bEdIMklheG1WY05qWWFvb0pYUUs1WG4zWTlqTEkzdGdoaG5PT2hyQ05Iby1YdlJyNFVpVTQwRjBkMXpYY0RpY2VEZ2lIaW9VQVg5dUxMUm5za1JyUllz?oc=5" target="_blank">Mapping cis -regulatory mutations at scale in sorghum enables modulation of gene expression</a>  <font color="#6f6f6f">Nature</font>

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
PNASgeneral

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE5FczItdjk3Qlg3dDFzWnpZQ19HRFFaekZ2aDVfeE5yVU5OcEt4R2t4ZHp0VVdIU3NzYk1oT0xvV0JUak5rOXl1VjR0ZUU1aFRDaTFCMzFJbEFiOXM3?oc=5" target="_blank">Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis</a>  <font color="#6f6f6f">PNAS</font>

Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape
Natureworld

Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1lTklvQUJqY0Q2RWdlbVM4QUhpdGZKeXgxVWE5Y016TUdieDZVcFRCdjI0dmg4aS13eWdkeWwtR1ZYVFl4cEZjWGNOZ2txU1lkYkstb3g0M2R3eDljXzJj?oc=5" target="_blank">Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape</a>  <font color="#6f6f6f">Nature</font>

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling
Naturetech

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBSa285ZjZtZnZBNTBreE1yTHp3d0toUl8zWjMxYjR4OUpRNVh0dnQ3U293M1laVXNrTEY0Tk15QzQzTUdncUhVVy14TVdITm1OUFBZazN4bGlXQ1VOWXFn?oc=5" target="_blank">Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling</a>  <font color="#6f6f6f">Nature</font>

Precise, predictable genome integrations by deep-learning-assisted design of microhomology-based templates
Naturegeneral

Precise, predictable genome integrations by deep-learning-assisted design of microhomology-based templates

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE10R2lPc0tCVEdGVjMwV3BrZzkzOFdyY3JlZFBkU2k0cU94bmxDVkd6LWVSWlljZ3R3T2JPT3RJdmMxTFE2bHVaQzhCMkU3cFRLNGNXV3JzZ3BmMEtvT2N3?oc=5" target="_blank">Precise, predictable genome integrations by deep-learning-assisted design of microhomology-based templates</a>  <font color="#6f6f6f">Nature</font>

In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region
PNASgeneral

In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE5VRmZuenpwRkRSQnFnZU95bzNlTUhVVHJ4NGpfWFVBOU41UzBEbWIyNzdiZUJpZzI1S25Dd0p2OFhITTRRYU4weG53T194bk90Uno3Q1A5NjdsVnNN?oc=5" target="_blank">In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region</a>  <font color="#6f6f6f">PNAS</font>

Engineered prime editors with minimal genomic errors
Naturegeneral

Engineered prime editors with minimal genomic errors

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5BcDBxRFZTR1Bfc3RtR09qelZ1V3NSM2xRNGItaGpHZEdieDZTbkFJSlRraGhPNGNLeW4xOTFDNlVPV0I5ckRXaGNqOHBwMXpPNm9oRS1zNk1PQ2diZ21z?oc=5" target="_blank">Engineered prime editors with minimal genomic errors</a>  <font color="#6f6f6f">Nature</font>

Deep-intronic variant of fukutin is the most prevalent point mutation of Fukuyama congenital muscular dystrophy in Japan
Naturegeneral

Deep-intronic variant of fukutin is the most prevalent point mutation of Fukuyama congenital muscular dystrophy in Japan

<a href="https://news.google.com/rss/articles/CBMiU0FVX3lxTFBDN01OeFotenQ5aVRVTzk0SVRidmctdkt6QW42eVNVcHE5NHRURGx4OWg1ekYzbXpvQkVWMEVrWEZEUER4R1ExVXc3V2ZBa3VmNWFn?oc=5" target="_blank">Deep-intronic variant of fukutin is the most prevalent point mutation of Fukuyama congenital muscular dystrophy in Japan</a>  <font color="#6f6f6f">Nature</font>

"Deep mutation, insertion" — Live Google News Trends & Headlines