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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Chemically modified CRISPR-Cas" (30 stories)

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Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation
Lead StoryNaturegeneral
Dec 9, 2025

Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1SR1RjRFNjRDhwWUszb3I5VmJpSTFyaW5ScmhjQ1EzUk5Ma0xsd1UxYW5DbzNnN0tMSHFNb1I2QjhJZC1WMHNaVzdyaW9vTkg1ODJzUFpaTnVYUXNVX1Ew?oc=5" target="_blank">Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "Chemically modified CRISPR-Cas"

Updated every 3 minutes via FreeNewsApi, GNews, Currents API & Google News

29 stories displayed
Cyanine-modified ssODNs enhance CRISPR-Cas9 HDR in stem cell embryo models via chromatin and chemical modulation
Naturegeneral

Cyanine-modified ssODNs enhance CRISPR-Cas9 HDR in stem cell embryo models via chromatin and chemical modulation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5nbDNTUGJtVDd3b2dXNExQMjBMdEd3c0ttWGJFWDJKc2NDTGd3WDY2Z1VwUnpTM0h3SUZUck9tU1lvNVotZEVHVkZYWDlUa3VZMHNSX0pxY2Y2LWRsS3pF?oc=5" target="_blank">Cyanine-modified ssODNs enhance CRISPR-Cas9 HDR in stem cell embryo models via chromatin and chemical modulation</a>  <font color="#6f6f6f">Nature</font>

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Press Release Service: Agilent to Appeal Patent Office Decision on CRISPR gRNA Patents
CRISPR Medicine Newsgeneral

Press Release Service: Agilent to Appeal Patent Office Decision on CRISPR gRNA Patents

<a href="https://news.google.com/rss/articles/CBMivwFBVV95cUxPSVAzdzFkSl9XbUNPbWVzSVBjcVJINlVhWEpPSWdaVWV4NjAyZUtvZUVyRUdVdnlQc181bWhWNWZDVEFhUVE3TXpnbWstLXpMek1SZC1PVGZQZ21YZE9fUlNBX1VXOFlqQS1SUlV4Z0t0M09Nak5YMElqbXRqWnJQTjRYN0JGVEZ3bUNacFRpMTYyZmJoMVlWWWM3X25XalV2Nkc3MUlZa2ZHekx2MFgteHByT1ByYUVVLVA0UE96SQ?oc=5" target="_blank">Press Release Service: Agilent to Appeal Patent Office Decision on CRISPR gRNA Patents</a>  <font color="#6f6f6f">CRISPR Medicine News</font>

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Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates
Science | AAASgeneral

Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1YYnV1Y0lha2JBMU9zeHVHaFBCaU5PU2QwN0pseDdzOTZsMzJsVDhsSTlOV3hQTi1xR3E0N0NpLTdraWloTnhRd2ZERUhabWxLUGhDaEhrMjVPMTU2TnJr?oc=5" target="_blank">Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates</a>  <font color="#6f6f6f">Science | AAAS</font>

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Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine
Frontierstech

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine

<a href="https://news.google.com/rss/articles/CBMilwFBVV95cUxOc1RjMWxCSW5nSDdIRDF1SEtzamsxVjltNXllWkwwZzd0X3JzeHdRSXNHZnlNRWt1YVFfLXR6Wkh3UXE1ZndDcllpYXJoWFFNZWhiR0xralJwTkJJMFQ0bTRsZ0F1cGJKSzdQaTJuZEJLVWVheEVHendzZFRScEMxQkNwTGliSXFROXA2dHNJSmE4dm81YWNJ?oc=5" target="_blank">Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine</a>  <font color="#6f6f6f">Frontiers</font>

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Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
Naturegeneral

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

<a href="https://news.google.com/rss/articles/CBMiUkFVX3lxTE9EMzFSQ2dEbUl1c0JXMW9IZkpFeVd4UzdUalc3RmcyS0owN1Jmb1YyZ0c0bHNUQ29RNlY0WUlsQzcyQTBVa3FSeG0zS1duNk04dEE?oc=5" target="_blank">Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells</a>  <font color="#6f6f6f">Nature</font>

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Explainer: What Are Base Editors and How Do They Work?
CRISPR Medicine Newstech

Explainer: What Are Base Editors and How Do They Work?

<a href="https://news.google.com/rss/articles/CBMikwFBVV95cUxQcTlmdDNCWDNlSGM2LTFsS3JNZnpFRFRFXzVuYnBLeEhOMlpQQ3diZFN2Z29LVE4xZEJiY0Jnb3BFdmlsVk9OSTVBT256RHV3MmpRU1ZsREU1MFNzMUQ4ZEplXzZfcWw4UmVzSXd0ZC1kVzh0XzJ6VDIyQmExWFljQ1dXYmkxX2pQd1J5S3lSc2JFMzQ?oc=5" target="_blank">Explainer: What Are Base Editors and How Do They Work?</a>  <font color="#6f6f6f">CRISPR Medicine News</font>

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Using Synthetically Engineered Guide RNAs to Enhance CRISPR Genome Editing Systems in Mammalian Cells
Frontiersgeneral

Using Synthetically Engineered Guide RNAs to Enhance CRISPR Genome Editing Systems in Mammalian Cells

<a href="https://news.google.com/rss/articles/CBMilgFBVV95cUxQTEpMR0phV2hRazBtQzFFeGlkNml1SzdrOGpUT0hMRllxSWFNOXhiUTdkRFNyTFJMclJrRGxXeUp5RlRrVFVIXzBnMkFIYTBob05qblM1Y2MwdXY2UVdhbUpzeUlFcmNjNDlHM0xKZG5oZTYxNGtTU0k1c2d6Y2J1SUg2VGxEcWd4M1ZzN3BaNGN5TGpuRlE?oc=5" target="_blank">Using Synthetically Engineered Guide RNAs to Enhance CRISPR Genome Editing Systems in Mammalian Cells</a>  <font color="#6f6f6f">Frontiers</font>

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Delivery: CART Nanoparticles Ferry CRISPR RNA Into Corneal Endothelium
CRISPR Medicine Newsgeneral

Delivery: CART Nanoparticles Ferry CRISPR RNA Into Corneal Endothelium

<a href="https://news.google.com/rss/articles/CBMiqgFBVV95cUxOY1dIaG5vemh1bUItb0NBR1luVzl2TzlmZG5jSlkyNWw0UWt1X05aczZBejlTdHVpZkczR0l6aDY1X2hnaURCNmllQi1xLThFbEc3VWVPQm1MZE9nRlM3RVl3YjBvUl9Ed25Icjgzc3hRVF9PMmwtRURCY0d3TEFCOGlIWFg3Sm1yd18zWHdJRHhKRll6NWxieDRCZXhDYkY1aE95V1QweW0wZw?oc=5" target="_blank">Delivery: CART Nanoparticles Ferry CRISPR RNA Into Corneal Endothelium</a>  <font color="#6f6f6f">CRISPR Medicine News</font>

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An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA
Naturegeneral

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1sVy1wZ1prOXZTLWJ3ZDBPMXdfak5FdmRKQ3VnWXlubktCaHlxcnVIaGZvUUF5NTdkTW5BdFk5SlltSTBmR1BLNnlyTDF1TjVId2t1cVd3T0tqWDlfaDRV?oc=5" target="_blank">An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA</a>  <font color="#6f6f6f">Nature</font>

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Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles
Naturegeneral

Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBGRlMtZjc0UUlMcVpyX2NVekFTQ2pFbDZRQldhdDZNOWZwb3RGNXlVSnBmU09VdjJuaE5pWnE2ZEdoNFZNbmEtWUZDOFJKNjgwSjVhMTZ2ZE1zb0pHdFRZ?oc=5" target="_blank">Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles</a>  <font color="#6f6f6f">Nature</font>

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Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA
Naturegeneral

Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9pV2lBTFdMRGJOMy1mdmhSXy15bVVleGpZZEFXczlRVlFFblhIczRQRGhKWjU5SEo3eWxFVkFRTDNDS1pCLWs1ZTJCRHM5dkFGZTdmRHMtLTNxeER2em9J?oc=5" target="_blank">Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA</a>  <font color="#6f6f6f">Nature</font>

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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
Naturegeneral

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE04MENndnhsckM2MUVESFZPT09xa3lsNkw1M0FKTjZfeDVrQnU3NE1ic2ZEa2pPVDVPMHM2MGl5clVWSnJldDNQaU00Ul94TE5WYk9iVGNwaXoyMWIwVmNr?oc=5" target="_blank">Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope</a>  <font color="#6f6f6f">Nature</font>

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Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage
Naturegeneral

Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9USHVLZGtBdDFRX3F0LWNOenV3MU9OemdXcUN4bmlGXzl1SlFYVVZidllXNjBzek9DOTh6aEtoa285cnNfZVJBd2xNNnh1alV6OEtrTDNSUzZJOGZPcWtZ?oc=5" target="_blank">Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage</a>  <font color="#6f6f6f">Nature</font>

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Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation
Naturegeneral

Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1fU1lPa0twSGxMNjNTZlhrMmhUS1FQb080VVIwZlpvcjdQU24yTTMtdHJZbnpzRXFrTjhoSFByYjNfZTdEM1Ntc0MxQmJMMjMzREpkQ3RBdmk3bTZlRFBJ?oc=5" target="_blank">Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation</a>  <font color="#6f6f6f">Nature</font>

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Improved Cas9 activity by specific modifications of the tracrRNA - Scientific Reports
Naturegeneral

Improved Cas9 activity by specific modifications of the tracrRNA - Scientific Reports

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE80R011VnNXMk1zU3QzeF84bnIxTzZfMkxKTFBEUU0zdmFObHFpVXNzemVWSkJOVGFnZFVhTWlyaTN6ZENPTm5NN29rRHlVa3NReFFNeEphN2FZbk9Nd1lJ?oc=5" target="_blank">Improved Cas9 activity by specific modifications of the tracrRNA - Scientific Reports</a>  <font color="#6f6f6f">Nature</font>

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A versatile, high-efficiency platform for CRISPR-based gene activation
Naturegeneral

A versatile, high-efficiency platform for CRISPR-based gene activation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBlQ1NLNG5heDd0VnFrTUw0NmhRdG5OZkgxU25Nc1h2YmJ2YkxxY2tzcGd5TDAzU1d0eDFvQXd3NnNCNVgyandHVWlURXYyZlZpQUluTWJPZGRvdTd4VE1B?oc=5" target="_blank">A versatile, high-efficiency platform for CRISPR-based gene activation</a>  <font color="#6f6f6f">Nature</font>

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Conditional control of RNA-guided nucleic acid cleavage and gene editing
Naturegeneral

Conditional control of RNA-guided nucleic acid cleavage and gene editing

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1SWEVNbElFOXNTMWZRM1hZa3Q0eXRRWS1mbTZBdUExSUhJbTNLRG13ZWhvN21jSnN0anZSSFJHV1ltUkQ5ODNCSlBlY05BVk01QXVNSG1EX1M0VFpqck9F?oc=5" target="_blank">Conditional control of RNA-guided nucleic acid cleavage and gene editing</a>  <font color="#6f6f6f">Nature</font>

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Engineering designer beta cells with a CRISPR-Cas9 conjugation platform
Naturegeneral

Engineering designer beta cells with a CRISPR-Cas9 conjugation platform

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBVYVkxVGIwMmN2ZTRZQUpKTUdkeDI2YjY3b3ZkNlgyOGk3RzM4NFpHc1doeW5kRlUzZjhOQVNiQWtzWkRTbmdXemhFbHlPQ0JRZUNhaWpsS0lQMVh1ODFz?oc=5" target="_blank">Engineering designer beta cells with a CRISPR-Cas9 conjugation platform</a>  <font color="#6f6f6f">Nature</font>

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CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics
Naturegeneral

CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBEZVV6Y043Vmsyb1QxMkxFakFqTlNYUkNqRzF6SVY4czlEQ0IxdlFBMmI1ZF9RODZaZzd6Mmh1UEMzOC1leVBBU1NBQVRNSHVZblNCUWQ1cUhLRUJycFZ3?oc=5" target="_blank">CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics</a>  <font color="#6f6f6f">Nature</font>

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Near-infrared light activatable chemically induced CRISPR system | Light: Science & Applications
Naturescience

Near-infrared light activatable chemically induced CRISPR system | Light: Science & Applications

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBJNGxkOV9Kay1MeDlCSGk3aDFqRVRxWk5OSXNZYVVnYVhKUEZKZFRWaWNxbkRtSlUxYWxJQWotaWZrWk5EcVN4NGJHaWgtLVMwMFJuV0FIWEJQWHhSdmNB?oc=5" target="_blank">Near-infrared light activatable chemically induced CRISPR system | Light: Science & Applications</a>  <font color="#6f6f6f">Nature</font>

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Enhanced RNA-targeting CRISPR-Cas technology in zebrafish
Naturetech

Enhanced RNA-targeting CRISPR-Cas technology in zebrafish

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE4tLUUzd3JzYWxGR29fZ2V5cHk0NHF4bkxQSnNuR0lqQ0I2X2wydUE4QkkySTNXOHJSZDFUZDlrMDlQWjgxTThxd08xYjBNcE9ScnlQMzFiRUx6STdfamxR?oc=5" target="_blank">Enhanced RNA-targeting CRISPR-Cas technology in zebrafish</a>  <font color="#6f6f6f">Nature</font>

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Harnessing noncanonical crRNA for highly efficient genome editing
Naturegeneral

Harnessing noncanonical crRNA for highly efficient genome editing

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE11a004S04xRWE2Y1BzNWl6MzZGWEZKUTBjVUotUDZ6YnNuNDZpeXk5WHhrWmlQYVlrNUtvMENWamlfR3Nudm96QjZGV3JNc3AwWE12MEUzQlltYkVNVGU4?oc=5" target="_blank">Harnessing noncanonical crRNA for highly efficient genome editing</a>  <font color="#6f6f6f">Nature</font>

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Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity
Naturegeneral

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE0zRHJCMEx2NmRMR1FtUl9RaDkyaUFlYkNoZ3Fwai1vQlBRU2dEQ0FNSFgxR2xaZktsS0ZSQ0RwZVR0Ujl2YS1pRFVGc25rVWx6VlhZZFZkbnU4YmVtR3A0?oc=5" target="_blank">Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity</a>  <font color="#6f6f6f">Nature</font>

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The promise of gene editing with CRISPR
Van Andel Institutegeneral

The promise of gene editing with CRISPR

<a href="https://news.google.com/rss/articles/CBMid0FVX3lxTE5GSnNNVU1vaTVpZEI1eGJ5b1Vya0xDRVRlTG1xRXhkVjduRmhNR05RQnVydmtKQVZvb2tIVElyNnlIb2xqU1FWSXdiTm5LYWFqTkFIQTN5MnRWUDRnV1dlNkwwczkxSWU5WUo0b0ViZlRRTE9WSG1B?oc=5" target="_blank">The promise of gene editing with CRISPR</a>  <font color="#6f6f6f">Van Andel Institute</font>

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Targeting Fusobacterium nucleatum through chemical modifications of host-derived transfer RNA fragments
Naturegeneral

Targeting Fusobacterium nucleatum through chemical modifications of host-derived transfer RNA fragments

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1rQkhPVlpoUEhyUHVrTWVxQ3VKcXVFWGpBa1BPWlpnYXdkc1lHR01pTjlPcUc2WXRnLXZqMFBoczhJNjNJaktLdU56d0lsWDZzMFFrc2Q0UmwtVFhQT3JN?oc=5" target="_blank">Targeting Fusobacterium nucleatum through chemical modifications of host-derived transfer RNA fragments</a>  <font color="#6f6f6f">Nature</font>

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Highly efficient and safe genome editing by CRISPR-Cas12a using CRISPR RNA with a ribosyl-2′-O-methylated uridinylate-rich 3′-overhang in mouse zygotes
Naturegeneral

Highly efficient and safe genome editing by CRISPR-Cas12a using CRISPR RNA with a ribosyl-2′-O-methylated uridinylate-rich 3′-overhang in mouse zygotes

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9VRDY1RjdJQ2NEcW9DRVhTR0MwbHpETjRkMk53Mm9wVkFpTEFaX1BKRE5BMElYekFmX1hUNlRwUnNvRFg5MkxpZERFS2lOODlNWUhrMFFHbndnTWpYb2ZN?oc=5" target="_blank">Highly efficient and safe genome editing by CRISPR-Cas12a using CRISPR RNA with a ribosyl-2′-O-methylated uridinylate-rich 3′-overhang in mouse zygotes</a>  <font color="#6f6f6f">Nature</font>

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Accelerated RNA detection using tandem CRISPR nucleases
Naturegeneral

Accelerated RNA detection using tandem CRISPR nucleases

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9FaG85YnE2cWFMbFFYMGJZZTFWT0J3UXkxLTVhRmREWEdLZnpzRWZtUTd4WkFHV05oNi13bzZBbnAtd3ZsUTRkNUd2MWl0SXlEaTNueTRVOF8ydU5jWXRV?oc=5" target="_blank">Accelerated RNA detection using tandem CRISPR nucleases</a>  <font color="#6f6f6f">Nature</font>

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Topology‐Engineered Guide RNAs for Programmable Control of CRISPR/Cas Activity
Wiley Online Librarygeneral

Topology‐Engineered Guide RNAs for Programmable Control of CRISPR/Cas Activity

<a href="https://news.google.com/rss/articles/CBMib0FVX3lxTFBreFFTc0RjbnlmTE9lS2RfRm5jd3dXbDgtRElTS2dkeHk0Qy1mSmRqbHBZTDh0V0hjQnNEbkY4VndGTFBIX2NGZnJtOVhkTXNucDZneGlzanltUFh6N3NJQXk0MEVoLVRFWUhjVk1lRQ?oc=5" target="_blank">Topology‐Engineered Guide RNAs for Programmable Control of CRISPR/Cas Activity</a>  <font color="#6f6f6f">Wiley Online Library</font>

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Recent advances in CRISPR-based single-nucleotide fidelity diagnostics
Naturegeneral

Recent advances in CRISPR-based single-nucleotide fidelity diagnostics

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE52OXBEVlpzYUtjWXhEY19uLWtFd21ubUFPTnpRZnQyV01wWGdNX2lySS1YQXJhQ2tGczZnWWMxQ1BCZ2tNVkp1bXEzd0R2M0taeVAzY2JkNU0zZ3lERjRn?oc=5" target="_blank">Recent advances in CRISPR-based single-nucleotide fidelity diagnostics</a>  <font color="#6f6f6f">Nature</font>

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"Chemically modified CRISPR-Cas" — Live Google News Trends & Headlines