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Category:All HeadlinesWorld & GeopoliticsMarkets & EconomyTech & AIPoliticsSearch results for: "Calcium overload induced" (30 stories)

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Calcium overload induced mitochondrial and lysosomal dysfunction is regulated by Tousled-like kinase in a-synucleinopathy
Lead StoryNatureworld
Jan 8

Calcium overload induced mitochondrial and lysosomal dysfunction is regulated by Tousled-like kinase in a-synucleinopathy

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE8xeHM3dEZyMTVDMFhmMFRlTGRmbjFYUUVRbi1YUmRQT3NXYklVV0J0UUI4TEFmdlhwYnNCOEZyZ2U5SmVfelV5dHh4a3FiZ3FYUVk0alhRTzJkUC0wOV9N?oc=5" target="_blank">Calcium overload induced mitochondrial and lysosomal dysfunction is regulated by Tousled-like kinase in a-synucleinopathy</a>  <font color="#6f6f6f">Nature</font>

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Search Results for "Calcium overload induced"

Updated every 3 minutes via FreeNewsApi, GNews, Currents API & Google News

29 stories displayed
Knockout of the Intracellular Calcium Conducting Ion Channel Mitsugumin 23 (MG23) Protects Against Pressure Overload Induced Left Ventricular Hypertrophy and Cardiac Dysfunction
Wiley & Sonstech

Knockout of the Intracellular Calcium Conducting Ion Channel Mitsugumin 23 (MG23) Protects Against Pressure Overload Induced Left Ventricular Hypertrophy and Cardiac Dysfunction

<a href="https://news.google.com/rss/articles/CBMid0FVX3lxTE5EVy1zMUNQY3d3TE04bFg2am9qNVhNSlQ5YjFKakxocTVvTXpic29NRGtnbUpYSGw0TU80czRSa1JSV2pEQW5fM1E1VU43SFM0YzdLbjRiUVc4bWo4NWRQcmdHaVZzZnlDSjc4b2lEWnJiSjJvRHNn?oc=5" target="_blank">Knockout of the Intracellular Calcium Conducting Ion Channel Mitsugumin 23 (MG23) Protects Against Pressure Overload Induced Left Ventricular Hypertrophy and Cardiac Dysfunction</a>  <font color="#6f6f6f">Wiley & Sons</font>

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Metabolic-stress-induced mitochondrial calcium dysregulation: a central hub in diabetic cardiomyopathy pathogenesis and treatment
Frontiersgeneral

Metabolic-stress-induced mitochondrial calcium dysregulation: a central hub in diabetic cardiomyopathy pathogenesis and treatment

<a href="https://news.google.com/rss/articles/CBMilgFBVV95cUxNNnFpckFKSzJYOEZiZjhVZEIwekxLSGdOUUJWT256eVpQWHE0RkdBX1E0a1RsbTdEaHV2a2ZmdERfQWhUTVpxVDdDSlR3QmNHVHlBMVFzS1AzTFpqQmlBN2xJa2g3Tnk1N3JaU2pUNi1NVGt5RWlwSGNLNVE0OVctbEgtbWIyVWJpd0FtZ0JRdzB5dlNlSmc?oc=5" target="_blank">Metabolic-stress-induced mitochondrial calcium dysregulation: a central hub in diabetic cardiomyopathy pathogenesis and treatment</a>  <font color="#6f6f6f">Frontiers</font>

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Mitochondrial calcium overload is the trigger for carbon monoxide neurotoxicity
Naturegeneral

Mitochondrial calcium overload is the trigger for carbon monoxide neurotoxicity

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ocDNnekphUlM1S3Q2UmtHZVJ1TWVqb2d0SllKa3h0TERJVnY2UUY1REdKTHk4V2pYUEN5OEVZZ21jYnVQeDFqUG90VmJraUVCVkw4ejV4QTRSSnZ4MEhr?oc=5" target="_blank">Mitochondrial calcium overload is the trigger for carbon monoxide neurotoxicity</a>  <font color="#6f6f6f">Nature</font>

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Calcineurin Plays a Critical Role in Pressure Overload–Induced Cardiac Hypertrophy
American Heart Association Journalsgeneral

Calcineurin Plays a Critical Role in Pressure Overload–Induced Cardiac Hypertrophy

<a href="https://news.google.com/rss/articles/CBMiakFVX3lxTE5nZmRUNHpST0xfYjF6WlBmTTI5eU9CdFZhUm90N0JYWWw2M2x1cUFncGVIajZRX1Nsd2JQNHpqSU14MXUzTk5uTzVwd0h2ZkJvOHl1VjBPc2RSWkRWTFlNRFdzSDVaSzNzdnc?oc=5" target="_blank">Calcineurin Plays a Critical Role in Pressure Overload–Induced Cardiac Hypertrophy</a>  <font color="#6f6f6f">American Heart Association Journals</font>

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Regulation of sodium/calcium homeostasis by BacNav gene therapy rescues cardiac dysfunction in chronic heart failure
Science | AAAStech

Regulation of sodium/calcium homeostasis by BacNav gene therapy rescues cardiac dysfunction in chronic heart failure

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9hUUJfLXJaOWUxcTVUcm5HRWhPMWJMajNOdDhOQ1VyemliTmk4XzVKR0VPdnFiRDdHS0t4UDFSTWtMdlNjWWE0QldQZDkySnQtZktSNVVGLVBxWG1PaHhZ?oc=5" target="_blank">Regulation of sodium/calcium homeostasis by BacNav gene therapy rescues cardiac dysfunction in chronic heart failure</a>  <font color="#6f6f6f">Science | AAAS</font>

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BPS Publications
British Pharmacological Society | Journalsgeneral

BPS Publications

<a href="https://news.google.com/rss/articles/CBMic0FVX3lxTFBfdGVfX0txV3ZBbkp2YUtkM25MMEFucDBYTy1seVFVOE12MmdkcVZuNlRFTGJOTjJNYWRXRFdqMkx3eEhRZjFhaTFuTTZxbHlsTnhTbjZfWGpBZU1TcTh5azZHbFVETkh3Mm02cVlZVXpOYUE?oc=5" target="_blank">BPS Publications</a>  <font color="#6f6f6f">British Pharmacological Society | Journals</font>

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Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death
American Heart Association Journalsgeneral

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death

<a href="https://news.google.com/rss/articles/CBMibkFVX3lxTE40VDE5SXN5LXZ3S2hwcTVGQmNvRUYzWlBOX3BLcXQ2d3lZMnpfVlExVjZEdmZFVTYtQWtoak9JYjBJZldEbzhOajNkRzFXTE1DclY3eHZKUFp4bC00VjhtbE5rTVdPa3NKZ1BQekZn?oc=5" target="_blank">Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death</a>  <font color="#6f6f6f">American Heart Association Journals</font>

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SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation
Naturegeneral

SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation

<a href="https://news.google.com/rss/articles/CBMiXkFVX3lxTE0xWlZudTkxTlhjUXJGMmxKQUlhNlNNZVNjWEJVa2RWU0F1dHYzcDBQU2s5OGtmbDV4dm5nV1VMcGNZblIyV2NFZldQaWVRN0FONWxiNWhIemxzNVJZenc?oc=5" target="_blank">SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation</a>  <font color="#6f6f6f">Nature</font>

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A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption
Naturegeneral

A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE85QlpBOVJSd0gxUldzWXdaVnpqQUcwMDlWZkduQ0cwODBubmJpZEFxQndpV3NKTHQ0cWpETFZ5a3VuOWVOb1FZOVUwUThpOHZoMm1KakZPNHZLU2VjZVpB?oc=5" target="_blank">A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption</a>  <font color="#6f6f6f">Nature</font>

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-induced hepatocytes is regulated through calcium overload and 58-F interference
Naturegeneral

-induced hepatocytes is regulated through calcium overload and 58-F interference

<a href="https://news.google.com/rss/articles/CBMiXEFVX3lxTE5tLXdqZDhtaGplWmtZbl9mNUEzVVRYRlpxSU1wX2loNVlqUFVUNWZWU3BaN084VFd2X2NvSzFZRXlRMVpKYmlVTUpUeVc4ZmJpOFhEc016cW9SeUNm?oc=5" target="_blank">-induced hepatocytes is regulated through calcium overload and 58-F interference</a>  <font color="#6f6f6f">Nature</font>

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Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
Naturetech

Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload

<a href="https://news.google.com/rss/articles/CBMiXkFVX3lxTE1XS0w3NDYwOTJBTTBPUHpZQ3NTRlZmd1M0UjZvcFllRXlJMm4yVGk3cDVCazE1WkR3Ym1qaWR2Z014WEtCc2F3R0VSZzhmQ3JYYnNiR1pZdzFVWHBGSEE?oc=5" target="_blank">Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload</a>  <font color="#6f6f6f">Nature</font>

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Fluorofenidone ameliorates pressure overload-induced heart failure by stabilizing SERCA2a in male mice
Naturetech

Fluorofenidone ameliorates pressure overload-induced heart failure by stabilizing SERCA2a in male mice

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9ZUzF1dGtBZDZFQXdOUW9ITmR2aFVsaGk0VjAxRlFLRzRiaVFDZTF1RU13bVl2MHREY0QzQ1Zyc0VRVV9DYWlVclpwM3I5aDZpYmVhVEdTeTFGRTgxVWdF?oc=5" target="_blank">Fluorofenidone ameliorates pressure overload-induced heart failure by stabilizing SERCA2a in male mice</a>  <font color="#6f6f6f">Nature</font>

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Impaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons with AIFM1 variant | Cell Death & Disease
Naturetech

Impaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons with AIFM1 variant | Cell Death & Disease

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9Pc2owVkpMekpnanVzMEppY0hZemZfSnVmQ0JsdkRwMHRuUkxSX1N1akZLV0NsaG5YQ0dTTkdpSkR2SWx2YzByd0tGTkJyUTZjVmpMMTlIVXB6OXY0SldJ?oc=5" target="_blank">Impaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons with AIFM1 variant | Cell Death & Disease</a>  <font color="#6f6f6f">Nature</font>

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FL3 mitigates cardiac ischemia-reperfusion injury by promoting mitochondrial fusion to restore calcium homeostasis
Naturegeneral

FL3 mitigates cardiac ischemia-reperfusion injury by promoting mitochondrial fusion to restore calcium homeostasis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE50RHBKREs4YjcxZS1LWnRGTmJOc2lkTWhPWV9BWkxJajlBR2QtSVdlNVY1ZU1mVWYzOUFndUZKemp4SWFyUlNxOWc2RTJzQktmWW9hdl9WaE9GeW1PRHlN?oc=5" target="_blank">FL3 mitigates cardiac ischemia-reperfusion injury by promoting mitochondrial fusion to restore calcium homeostasis</a>  <font color="#6f6f6f">Nature</font>

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Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases
Naturegeneral

Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFBzSTdTcjVTTlRubmZHYzZqSktsM3dqREtFY3ZvQzJfclNGZlVyQUNybVB4eXpld2FELWxOOXk5S2w4N2ktS3dpNzVzVkhfbXh1OHRxT1kyTjJySXNnUko0?oc=5" target="_blank">Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases</a>  <font color="#6f6f6f">Nature</font>

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The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function
Natureworld

The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5wRjZSTmZkdUowX3lleUhYNXFzYlpfT0diVnAxamk2RU0zVEZsT1R4WTluYU91cFJHVkJGQ0NGYS0tb2d4NE16UC1ZeHB2ZW9vTmhIcUJKOGFWT1JpaXlF?oc=5" target="_blank">The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function</a>  <font color="#6f6f6f">Nature</font>

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Rebalancing calcium in Alzheimer disease
Naturegeneral

Rebalancing calcium in Alzheimer disease

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE1HMlA2NG1NMnZscDNVTnUyTUl1MTdjdXZodFF1YWh4cFBGRmpRWWJha1VTV3dNb0hhQWhXdUZYMUdhSUhxOTZZc0xUYTlmUXpGUXF5UGdFU19VaFBkS0w0?oc=5" target="_blank">Rebalancing calcium in Alzheimer disease</a>  <font color="#6f6f6f">Nature</font>

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Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway
Naturetech

Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTFB1ZU9UdEh2RktCbFVkLVNmX0lsWXdCMEwtSkpjVkIyc3ctLUNKUW9TbTZWeF8yT0FMdzZKeEpGZlF3OHRTM0tqN1YyUE9MNjZ4TE81X2JCN3V2djJNVVNB?oc=5" target="_blank">Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway</a>  <font color="#6f6f6f">Nature</font>

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TBC1D15-regulated mitochondria–lysosome membrane contact exerts neuroprotective effects by alleviating mitochondrial calcium overload in seizure
Naturegeneral

TBC1D15-regulated mitochondria–lysosome membrane contact exerts neuroprotective effects by alleviating mitochondrial calcium overload in seizure

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5TbkY4Wldlc0NwY2Y0OHQwX3Y3akUzLVBkZV9TaEUwYkNQVnFiYm1YWkYwSDlPRG1mWXV1bm1hWnliV3VDcUY2N1FBc2R2Q0Y1cTcwYmFwQTZ6UkpCLWFR?oc=5" target="_blank">TBC1D15-regulated mitochondria–lysosome membrane contact exerts neuroprotective effects by alleviating mitochondrial calcium overload in seizure</a>  <font color="#6f6f6f">Nature</font>

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Sulfite triggers sustained calcium overload in cultured cortical neurons via a redox-dependent mechanism
ScienceDirect.comtech

Sulfite triggers sustained calcium overload in cultured cortical neurons via a redox-dependent mechanism

<a href="https://news.google.com/rss/articles/CBMie0FVX3lxTFBPNWRPVlo5b1g5QU4tRS05cFYxQVA5dDFfVUlZUURDUjk0U2xRX3dqNl9qSG96Q1JVVS1aYUhkZmlUSVNEdVFUcjlGLXdqUE8zdzh0cmFXbVUtNmNNZXRxOHVuZUN3ajE3c3AxZ2tpc0tST1ZiTGVZS2ZxSQ?oc=5" target="_blank">Sulfite triggers sustained calcium overload in cultured cortical neurons via a redox-dependent mechanism</a>  <font color="#6f6f6f">ScienceDirect.com</font>

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The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
Frontiersgeneral

The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxQai1aMzJnWGVoRDZ1SFBkdWZVdFJCaUZmRU9wNmlKR0lBYXNSSi1kcDVtcXB2bnpOMzNTd0loNzFfdlo4c2lkaTgzeVVYMkVQSTdLYkd1d0RuUXRvaTBrMHZLUnN3aXpqbnM4WjUzd29YMGJreGZ1WHg0ZGd5TjF0YUhhaW1zSG8tWnoxY043X2wyUQ?oc=5" target="_blank">The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes</a>  <font color="#6f6f6f">Frontiers</font>

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PKM2 deficiency exacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiac calcium homeostasis
Naturegeneral

PKM2 deficiency exacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiac calcium homeostasis

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE96cm9rWGk1MVFUSWt0NEV1YWlHZ2JLeExaNW0tdVRlWVN1UVNjeVYzQWNKTlhDcl85ZVlaMlB2SmFHTGdvTE1qOTVFZU5wNW9MNmJUeHY2cVpIQmhoZk9F?oc=5" target="_blank">PKM2 deficiency exacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiac calcium homeostasis</a>  <font color="#6f6f6f">Nature</font>

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Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
Naturegeneral

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE5IWExtdTNsQVVJR3dnQ2F1UEo5NERmQ0h0aERvMlU0TkNUbWhMMVJHYk96RVk3Z3ZUNW1BbHVJYS1WVmpodzhYOFRMX0hSTmFvWHRUZmVHWlpQekJ3RFdr?oc=5" target="_blank">Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease</a>  <font color="#6f6f6f">Nature</font>

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Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation
Naturegeneral

Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE9kdWI4Rld5UWpRRFdDWVUybG1IU1lIVzF4eU5SODF4SVkyUkxhSUt1NzhZLUI3TDR5eWxrRzdTZTY3U05TMVhHQUItZGlkLWhQZlBCQ0w2UmZjQ0N4Zjkw?oc=5" target="_blank">Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation</a>  <font color="#6f6f6f">Nature</font>

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Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine
Naturetech

Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine

<a href="https://news.google.com/rss/articles/CBMiU0FVX3lxTE0ySndjX3JieHlWUXdYZ2xUTHFmQmtLcU9tYUxuZWVRRFdtbnNqWVdzbHRRN2JTc25aUlhyNmRjVi1YVmlUdk9FOHR5bVhPaVZodGlB?oc=5" target="_blank">Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine</a>  <font color="#6f6f6f">Nature</font>

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Calcium Signaling and Reactive Oxygen Species in Mitochondria
American Heart Association Journalsgeneral

Calcium Signaling and Reactive Oxygen Species in Mitochondria

<a href="https://news.google.com/rss/articles/CBMibkFVX3lxTE8tM2x3SHZ4b3o5M2xOZ1kwUDV6ME9kUnJXNzRTUzRFbWNIVl9mQXBXczdIOWJfSEhNUFk5WjBPU2czQUQ2b25EQlAwTmpNWDVOVDFrMjFZTGEyTHAwb2hRMDJvbFhmZ0N3cnFyekJR?oc=5" target="_blank">Calcium Signaling and Reactive Oxygen Species in Mitochondria</a>  <font color="#6f6f6f">American Heart Association Journals</font>

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The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet
Natureworld

The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet

<a href="https://news.google.com/rss/articles/CBMiX0FVX3lxTE12clMxV05hQy1kZmxmc2xEVU1mMGpyMUhHWGp5MnVWdTllcksxQS1EV3MzR2dvd29UdUZ3ZC1iWERKUUIyM0xpMC1reXdDR250UFoxUS0tSk1nRGVnOTFj?oc=5" target="_blank">The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet</a>  <font color="#6f6f6f">Nature</font>

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Mitochondrial dysfunction in pancreatic acinar cells: mechanisms and therapeutic strategies in acute pancreatitis
Frontiersworld

Mitochondrial dysfunction in pancreatic acinar cells: mechanisms and therapeutic strategies in acute pancreatitis

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxNUkd2RXFrWjhGckFqeWQxWkJZbEdUNjdMc2hPblFpSFYwTnZJelQ4eURmVXpWbmppMVFyeGZ1WFVnLU9QeVBFLUI1eG10U2xrX0RURTM5Zno4UXAwSDh2Mm03TkxlSEM2T3JnVWdsWjYxTFhRd3k3ZE5sZFhjTWxKT3pzMEJjcGZ4X292UnA5eHVrUQ?oc=5" target="_blank">Mitochondrial dysfunction in pancreatic acinar cells: mechanisms and therapeutic strategies in acute pancreatitis</a>  <font color="#6f6f6f">Frontiers</font>

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Excitotoxic Calcium Overload in a Subpopulation of Mitochondria Triggers Delayed Death in Hippocampal Neurons
Journal of Neurosciencegeneral

Excitotoxic Calcium Overload in a Subpopulation of Mitochondria Triggers Delayed Death in Hippocampal Neurons

<a href="https://news.google.com/rss/articles/CBMiV0FVX3lxTE1OaTd4aTNLaDVPNURhOEpMdU9pZVRyeVY1ZVhWUlN2MGZYcHZKeURqM3dZNDhucUFqWmZSclRuV2JweHZKc1V3S0VMa25yZG5tSHpVeXNzcw?oc=5" target="_blank">Excitotoxic Calcium Overload in a Subpopulation of Mitochondria Triggers Delayed Death in Hippocampal Neurons</a>  <font color="#6f6f6f">Journal of Neuroscience</font>

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"Calcium overload induced" — Live Google News Trends & Headlines